Validation of groundwater models is relatively challenging due to the need to reserve scarce water level data for calibration targets. In addition, traditional statistical validation metrics are unintuitive for non-technical audiences and do not directly identify model behaviors that require further refinement. We developed a novel model validation method that analyzes rate change events at pump-and-treat wells and statistically compares the water level responses at nearby monitoring wells between the data and model. The method takes advantage of events that occur alongside ambient pumping, unlike parameter estimation techniques that require independent drawdown or recovery events. The ability of the model to match well connections that are evident (or not evident) in the observations is characterized statistically, leading to four decision scenarios: model matches the observed connection (1) or lack thereof (2), model exhibits a connection that is not observed (3), or model over- or understates the observed connection (4). The method is applied to an FEHM-based groundwater flow and transport model that is shown to match 84.5% of the well connections analyzed. The method provides novel perspectives on the influence of calibration targets on the flow field and suggests that although the overall effect of drawdown targets was to improve the model, the choice of target well pairs creates flow pathways that may be inconsequential during normal operational conditions. The model adequately matches the flow over short spatial scales (<800 m) and over-represents the flow over greater distances (300–1200 m), suggesting the need for “null” drawdown targets in subsequent rounds of calibration.