The elastic deformation of the front subframe during vehicle traveling affects the vehicle handling stability. The static equilibrium equations of the suspension and subframe system and the kinematics equations of the three-degree-of-freedom vehicle are established to illustrate the principle of the influence of the flexible front subframe on the handling stability. The front subframe is flexibly processed to establish a rigid-flexible coupled vehicle model. Simulations of the suspension kinematic and compliance alongside sine swept steering simulation of the vehicle are performed. The front subframe bushing stiffness, which has a greater impact on the handling stability, is selected as a design variable through parametric test design, and the NSGA-II algorithm is used for multi-objective optimization with the vehicle handling stability evaluation index as the optimization target. The simulation results show that the flexible front subframe will make the bushing force change to affect the suspension kinematic and compliance characteristics and then affect the vehicle handling stability, the gain of vehicle yaw rate and the delay time of lateral acceleration decrease, while the gain of roll angle increases. The optimization results show that the optimized vehicle exhibits improvements in the yaw rate gain, delay time of lateral acceleration, and roll angle gain.