Seismic source location is a classic inverse problem in seismology. In mathematical physics, inverse problems have multiple natural solutions. The objective of this study was to develop a generic theory and method of seeking the true solution from multiple solutions for the location of a coal mine seismic source in an idealized velocity structure model of a coal mine with a small scale and complex geological environment. Starting from the simplest velocity structure model, the complexity of the model gradually increased, until it approached the real velocity structure model, i.e., the multilayered horizontal and inclined velocity structure model, in order to find a generic method for solving the multi-solution inverse problem of coal mine seismic source location. Specifically, the wavefront distribution equation in a two-layer horizontal medium was derived and then expanded to any multi-layer horizontal medium. Based on this equation, a positive definite nonlinear equation system was established from the perspective of any observation system. The equation system contained four unknown variables of the spatiotemporal position of the seismic source. To determine the spatiotemporal parameters of the seismic source, nonlinear equations for four stations were required. To solve the nonlinear equation system, an initial iteration value was determined. In order to reduce the difficulty of determining the initial iteration value, the variable substitution method was used to reduce the number of location parameters. By rotating the original geodetic coordinate system of the station to be parallel and orthogonal to the medium interface, the wavefront method was extended to inclined medium. In conclusion, in this study, the problem of coal mine seismic source location in a multi-layer horizontal or inclined medium was effectively solved. The method proposed in this study provides a reference for solving the true solution from multiple solutions for the location of a coal mine seismic source in small-scale coal mines with complex geological environments.