Palsy Patients Research Articles

Support Vector Machine for Stroke Risk Prediction

Nowadays, there are many paralytic patients sent to the hospital, and it is impossible for hospitals to search out those particular patients at once because these patients share the same symptoms such as unconsciousness as those hypoglycemic patients. Nowadays, most patients need to conduct blood tests to ensure whether they have a stroke or not. However, this will take a lot of time and resources. The investigation aims at stroke prediction. By using machine learning, the model will be used to train and test data. Support vector machine (SVM) will be used in this project. By using a support vector classifier (SVC), the model will be trained to learn from data. Then it will react to another data set to find out if it is fitted. As a classification problem, the accuracy is 0.77. It shows that certain model performs well after training which reflects that the prediction is successful. What’s more, its high recall which is 0.83 means that the model of stroke prediction can surely offer some help to patient classification to some extent because it can find most of the paralytic patients among all the samplers. Stroke prediction trained by the SVM model can help make the first division among all patients which can help save a lot of time and energy. However, since there is still a little deviation, it is still need to keep pace with modern medical technology to improve it.

Long-term functional outcome of secondary shoulder surgery in brachial plexus birth palsy patients.

Multiple secondary surgical procedures of the shoulder, such as soft-tissue releases, tendon transfers, and osteotomies, are described in brachial plexus birth palsy (BPBP) patients. The long-term functional outcomes of these procedures described in the literature are inconclusive. We aimed to analyze the literature looking for a consensus on treatment options. A systematic literature search in healthcare databases (PubMed, Embase, the Cochrane library, CINAHL, and Web of Science) was performed from January 2000 to July 2020, according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines. The quality of the included studies was assessed with the Cochrane ROBINS-I risk of bias tool. Relevant trials studying BPBP with at least five years of follow-up and describing functional outcome were included. Of 5,941 studies, 19 were included after full-text screening. A total of 15 surgical techniques were described. All studies described an improvement in active external rotation (range 12° to 128°). A decrease in range of motion and Mallet score after long-term (five to 30 years) follow-up compared to short-term follow-up was seen in most studies. The literature reveals that functional outcome increases after different secondary procedures, even in the long term. Due to the poor methodological quality of the included studies and the variations in indication for surgery and surgical techniques described, a consensus on the long-term functional outcome after secondary surgical procedures in BPBP patients cannot be made.

P-106 Spontaneous pupil fluctuations differentiate progressive supranuclear palsy patients from healthy controls

P-106 Spontaneous pupil fluctuations differentiate progressive supranuclear palsy patients from healthy controls

Risk factors for 90-day readmission and prolonged length of stay after hip surgery in children with cerebral palsy

ObjectiveSpastic hip dysplasia is a common complication of cerebral palsy in children, and surgical intervention is usually warranted. While current literature has primarily analyzed single institution outcomes, this study utilized a national database to describe readmission rates and factors correlated with readmission for children with cerebral palsy undergoing hip surgery in order to treat this population more effectively. MethodsThis study queried the Nationwide Readmissions Database (2014–2018) for pediatric patients with cerebral palsy who underwent hip surgery. Patient demographics, pre-operative comorbidities, length of stay (LOS), treatment complications, and readmission data were collected for each patient and analyzed with inferential statistics. ResultsOf the 1225 patients included, the average age was 9.3 ± 3.8 years and 42.8% were female. Approximately 26.3% patients had a prolonged LOS (≥5 days) and 14.2% patients required readmission within 90-days of surgery. Medical complications, cardiac arrhythmias, and iron deficiency anemia were all significantly associated with elongated LOS as well as 90-day readmission. Patients with Medicaid were more frequently associated with an inpatient medical complication and the overall complication rate was 5.5%. ConclusionsWhile current literature has analyzed common risk factors and complications associated with hip surgery in the pediatric cerebral palsy patient, this study identifies a national readmission rate (14.2%) as well as preoperative comorbidities associated with readmission within 90-days and/or elongated LOS. Notably, complications are more frequently associated with patients using Medicaid. These results further exemplify the importance of equitable access to care and thorough selection of pediatric cerebral palsy patients appropriate for hip surgery.

Uncovering spatiotemporal patterns of atrophy in progressive supranuclear palsy using unsupervised machine learning.

To better understand the pathological and phenotypic heterogeneity of progressive supranuclear palsy and the links between the two, we applied a novel unsupervised machine learning algorithm (Subtype and Stage Inference) to the largest MRI data set to date of people with clinically diagnosed progressive supranuclear palsy (including progressive supranuclear palsy-Richardson and variant progressive supranuclear palsy syndromes). Our cohort is comprised of 426 progressive supranuclear palsy cases, of which 367 had at least one follow-up scan, and 290 controls. Of the progressive supranuclear palsy cases, 357 were clinically diagnosed with progressive supranuclear palsy-Richardson, 52 with a progressive supranuclear palsy-cortical variant (progressive supranuclear palsy-frontal, progressive supranuclear palsy-speech/language, or progressive supranuclear palsy-corticobasal), and 17 with a progressive supranuclear palsy-subcortical variant (progressive supranuclear palsy-parkinsonism or progressive supranuclear palsy-progressive gait freezing). Subtype and Stage Inference was applied to volumetric MRI features extracted from baseline structural (T1-weighted) MRI scans and then used to subtype and stage follow-up scans. The subtypes and stages at follow-up were used to validate the longitudinal consistency of subtype and stage assignments. We further compared the clinical phenotypes of each subtype to gain insight into the relationship between progressive supranuclear palsy pathology, atrophy patterns, and clinical presentation. The data supported two subtypes, each with a distinct progression of atrophy: a 'subcortical' subtype, in which early atrophy was most prominent in the brainstem, ventral diencephalon, superior cerebellar peduncles, and the dentate nucleus, and a 'cortical' subtype, in which there was early atrophy in the frontal lobes and the insula alongside brainstem atrophy. There was a strong association between clinical diagnosis and the Subtype and Stage Inference subtype with 82% of progressive supranuclear palsy-subcortical cases and 81% of progressive supranuclear palsy-Richardson cases assigned to the subcortical subtype and 82% of progressive supranuclear palsy-cortical cases assigned to the cortical subtype. The increasing stage was associated with worsening clinical scores, whilst the 'subcortical' subtype was associated with worse clinical severity scores compared to the 'cortical subtype' (progressive supranuclear palsy rating scale and Unified Parkinson's Disease Rating Scale). Validation experiments showed that subtype assignment was longitudinally stable (95% of scans were assigned to the same subtype at follow-up) and individual staging was longitudinally consistent with 90% remaining at the same stage or progressing to a later stage at follow-up. In summary, we applied Subtype and Stage Inference to structural MRI data and empirically identified two distinct subtypes of spatiotemporal atrophy in progressive supranuclear palsy. These image-based subtypes were differentially enriched for progressive supranuclear palsy clinical syndromes and showed different clinical characteristics. Being able to accurately subtype and stage progressive supranuclear palsy patients at baseline has important implications for screening patients on entry to clinical trials, as well as tracking disease progression.

Effects of joint loading on the development of capital femoral epiphysis morphology.

The deleterious influence of increased mechanical forces on capital femoral epiphysis development is well established; however, the growth of the physis in the absence of such forces remains unclear. The hips of non-ambulatory cerebral palsy (CP) patients provide a weight-restricted (partial weightbearing) model which can elucidate the influence of decreased mechanical forces on the development of physis morphology, including features related to development of slipped capital femoral epiphysis (SCFE). Here we used 3D image analysis to compare the physis morphology of children with non-ambulatory CP, as a model for abnormal hip loading, with age-matched native hips. CT images of 98 non-ambulatory CP hips (8-15years) and 80 age-matched native control hips were used to measure height, width, and length of the tubercle, depth, width, and length of the metaphyseal fossa, and cupping height across different epiphyseal regions. The impact of age on morphology was assessed using Pearson correlations. Mixed linear model was used to compare the quantified morphological features between partial weightbearing hips and full weightbearing controls. In partial weightbearing hips, tubercle height and length along with fossa depth and length significantly decreased with age, while peripheral cupping height increased with age (r > 0.2, P < 0.04). Compared to normally loaded (full weightbearing) hips and across all age groups, partially weightbearing hips' epiphyseal tubercle height and length were smaller (P < .05), metaphyseal fossa depth was larger (P < .01), and posterior, inferior, and anterior peripheral cupping heights were smaller (P < .01). Smaller epiphyseal tubercle and peripheral cupping with greater metaphyseal fossa size in partial weightbearing hips suggests that the growing capital femoral epiphysis requires mechanical stimulus to adequately develop epiphyseal stabilizers. Deposit low prevalence and relevance of SCFE in CP, these findings highlight both the role of normal joint loading in proper physis development and how chronic abnormal loading may contribute to various pathomorphological changes of the proximal femur (i.e., capital femoral epiphysis).

Evidence-based Considerations on Donor Nerve Selection and Ideal Muscle Weight in Long-standing Facial Paralysis – The Freiburg Algorithm

Introduction: Free functional muscle transfer (FMT) is the standard for smile reconstruction in long-standing facial paralysis. Using the contralateral NVII for innervation of the transferred muscle frequently produces satisfying results. However, axon counts of facial nerve branches used as donor nerves for cross-face nerve grafts (CFNG) generally decrease with age resulting in insufficient muscle contraction. Also, the volume of the transferred muscle segment necessary for symmetric oral excursion depends on the donor nerve. This study presents our algorithm for donor nerve selection and ideal muscle weight in long-standing facial paralysis. Materials and Methods: In a prospective cohort study, we evaluated facial palsy patients scheduled for dynamic smile reanimation preoperatively via EMG for involuntary masseter muscle activation upon smiling. Six months after noting the first muscle contraction, we assessed smile synchronicity and correlated the results with the EMG results. Furthermore, we correlated oral commissure amplitude with the weight of the muscle segment and the donor nerve used. Results: We recruited 30 patients for the prospective study and included 22 patients in the retrospective analysis. Postoperatively, all patients demonstrated a voluntary smile. The preoperative coactivation of the masseter muscle predicted the outcome regarding synchronicity of the smile with high sensitivity and specificity. Also, we observed a significant increase in oral commissure excursion with increasing muscle weight when using the NV. Conclusion: The lack of masseter coactivation upon smiling predicts the absence of a synchronous, involuntary smile after FMT using the masseteric nerve. The ideal muscle weight depends on the donor nerve and should be smaller for the NV.

Automatic grading of patients with a unilateral facial paralysis based on the Sunnybrook Facial Grading System - A deep learning study based on a convolutional neural network

PurposeIn order to assess the severity and the progression of a unilateral peripheral facial palsy the Sunnybrook Facial Grading System (SFGS) is a well-established grading system due to its clinical relevance, sensitivity, and robust measuring method. However, training is required in order to achieve a high inter-rater reliability. This study investigated the automated grading of facial palsy patients based on the SFGS using a convolutional neural network. MethodsA total of 116 patients with a unilateral peripheral facial palsy and 9 healthy subjects were recorded performing the Sunnybrook poses. A separate model was trained for each of the 13 elements of the SFGS and then used to calculate the Sunnybrook subscores and composite score. The performance of the automated grading system was compared to three clinicians experienced in the grading of a facial palsy. ResultsThe inter-rater reliability of the convolutional neural network was within the range of human observers, with an average intra-class correlation coefficient of 0.87 for the composite Sunnybrook score, 0.45 for the resting symmetry subscore, 0.89 for the symmetry of voluntary movement subscore, and 0.77 for the synkinesis subscore. ConclusionsThis study showed the potential of the automated SFGS to be implemented in a clinical setting. The automated grading system adhered to the original SFGS, which makes the implementation and interpretation of the automated grading more straightforward. The automated system can be implemented in numerous settings such as online consults in an e-Health environment, since the model used 2D images captured from a video recording.

Recovery and functional outcome after radial nerve palsy in adults with a humeral shaft fracture: a multicenter prospective case series

The consequences of radial nerve palsy associated with a humeral shaft fracture are unclear. The aim of this study was to examine the functional recovery of radial nerve palsy, at presentation or postoperatively, in patients with a humeral shaft fracture. Data from patients who participated in the HUMeral shaft fractures: measuring recovery after operative versus non-operative treatment (HUMMER) study, a multicenter prospective cohort study including adults with a closed humeral shaft fracture Arbeitsgemeinschaft für Osteosynthesefragen (AO) type 12A or 12B, and had radial nerve palsy at presentation or postoperatively, were extracted from the HUMMER database. The primary outcome measure was clinically assessed recovery of motor function of the radial nerve. Secondary outcomes consisted of treatment, functional outcome (Disabilities of the Arm, Shoulder, and Hand and Constant-Murley Score), pain level, quality of life (Short Form-36 and EuroQoL-5D-3L), activity resumption, and range of motion of the shoulder and elbow joint at 12 months after trauma. Three of the 145 nonoperatively treated patients had radial nerve palsy at presentation. One recovered spontaneously and 1 after osteosynthesis. Despite multiple surgical interventions, the third patient had no recovery after entrapment between fracture fragments. Thirteen of the 245 operatively treated patients had radial nerve palsy at presentation; all recovered. Nine other patients had postoperative radial nerve palsy; 8 recovered. One had ongoing recovery at the last follow-up, after nerve release and suture repair due to entrapment under the plate. At 12 months, the functional outcome scores of all patients suggested full recovery regarding functional outcome, pain, quality of life, activity resumption, and range of motion. Radial nerve palsy in patients with a humeral shaft fracture at presentation or postoperatively functionally recovers in 94% and 89%, respectively.

GERD surgery in non-neurologic patients: Modified Laparoscopic Hill-Snow Repair is a valid alternative to Nissen fundoplication. Results of a 20 years of follow-up

Nowadays laparoscopic Nissen fundoplication represents the gold standard in surgical treatment of complicated Gastro-Esophageal-Reflux Disease (GERD), above all in cerebral palsy patients. In non-neurological patients without gastrostomy Nissen fundoplication can create some problems (gas bloat syndrome, dysphagia). Laparoscopic Hill-Snow repair is an established surgical alternative, but it is reported only in adult population. We describe our modification of Hill-Snow technique and our experience in a large series of non-neurological children in order to report its effectiveness and applicability in pediatric patients affected by complicated GERD. Between 2000 and 2022, 319 children underwent surgical correction of gastro-esophageal reflux at our Department. All were affected by complicated gastro-esophageal reflux unresponsive to PPI (Proton Pump Inhibitors). 251 underwent laparoscopic Nissen fundoplication; 68 non-neurological patients underwent laparoscopic Hill-Snow repair. Of these 68 children 48 were males (71%) and 20 females (29%); median age was 5years (3 months-11 years). Weight range was 4-37kg. 52 patients (76.5%) presented the following symptoms: retrosternal pain, dysphagia, regurgitation, coughing, failure to thrive, persisting reflux esophagitis. 16 (23.5%) had chronic respiratory problems (aspiration, apneic-spells, dysphagia, coughing, choking, gagging). For 8 (11.8%) symptoms were expression of chronic recurrent gastric volvulus. All underwent modified-laparoscopic-Hill-Snow repair. Contrast study showed sliding hiatal hernia in 55 patients (81%), while endoscopy demonstrated 16 cases of histologically severe esophagitis (23.5%) and 52 of mild esophagitis (76.5%). No intraoperative/postoperative complications were recorded. 60patients had a complete follow-up (range 1-20 years). 60/68 patients were evaluated with barium-swallow-study at 6-12 months; 40/68 patients with upper-gastrointestinal-endoscopy at 12months. No relapse was reported. 50 patients (73.7%) were symptom-free. 18 (26.3%) referred occasional epigastric pain, associated with vomit in 2 cases. 64 (94.1%) referred ability to vomit; 4 temporary difficulty to swallow (average 30 days). All patients reported being able to burp. 3(4.5%) presented episodes of gas-air-bloat during the first 2 months with spontaneous resolution. No case of dumping syndrome was recorded. This technique's modification yields excellent results in term of relapse and side effects at long-term follow-up. We reported the first and largest pediatric series in non-neurological children with encouraging results.

Is Minimally Invasive Bipolar Technique a Better Alternative to Long Fusion for Adult Neuromuscular Scoliosis?

Prospective cohort study. To report the results for an alternative technique based on minimally invasive fusion-less surgery. This approach is original in that it corrects deformities by proximal and distal fixation, with reliable pelvic fixation through the use of iliosacral screws on osteoporotic bones. Adult cerebral palsy patients requiring spinal correction surgery were included prospectively between 2015 and 2019. The technique involved the use of a double-rod construct anchored proximally by four clawed hooks and distally by iliosacral screws, in a minimally invasive approach. Cobb angle and pelvic obliquity were measured before and after initial surgery and at final follow-up. Complications and functional results were reviewed. This group (P) was compared with a second group (R) of patients who underwent surgery between 2005 and 2015, for whom data were collected retrospectively. Thirty-one patients were included in group P, and 15 in group R. The two groups were comparable for demographic data and deformity. At most recent follow-up (3years for group P [2-6] and 5years for group R [2-16]), neither correction nor surgical complications differed between the two groups. However, group P had 50% less blood loss and a lower medical complication rate than group R. Our results confirm the effectiveness of this minimally invasive technique for neuromuscular scoliosis in adults. The results were similar to those obtained with the usual techniques, but with fewer medical complications. Confirmation of these results is now required for a longer follow-up period.

Gracilis Muscle-Free Flap Objective Improvement of Oral Commissure Excursion in Facial Palsy Reanimation Surgery: Systematic Review and Meta-Analysis.

Background: Facial palsy patients face significant challenges. Gracilis free flap transfer is a key procedure in facial reanimation. Objective: This study aims to analyze oral commissure excursion improvement after gracilis free flap transfer and the differences regarding donor nerve: cross-facial nerve graft (CFNG), hypoglossal or spinal accessory nerves, motor nerve to masseteric (MNTM), and most recently, double anastomosis using both the MNTM and CFNG. Methods: A systematic review and meta-analysis were conducted of studies reporting oral commissure excursion improvement after free gracilis muscle transfer. Pooled proportions were calculated using a random-effects model. Results: Eighteen studies, 453 patients, and 488 free gracilis flaps were included. The mean change in perioperative oral commissure excursion was 7.0 mm, for CFNG 7.2 mm, for MNTM 7.7, and for double anastomoses 5.5 mm. Conclusions: There is a significant improvement in oral commissure excursion after gracilis muscle-free flap. Unfortunately, we could not make definitive conclusions regarding the optimal choice of donor nerve.

Effectiveness of Extracorporeal Shockwave Therapy on Controlling Spasticity in Cerebral Palsy Patients: A Meta-Analysis of Timing of Outcome Measurement

Extracorporeal shockwave therapy (ESWT) has been suggested as an alternative treatment for reducing spasticity in patients with cerebral palsy (CP). However, the duration of its effect was rarely known. A meta-analysis was performed to investigate the effectiveness of ESWT at controlling spasticity in patients with CP according to the follow-up period. We included studies in which ESWT was used to manage spasticity in patients with CP, and the effect was compared with that in a control group. Finally, three studies were included. In the meta-analysis, spasticity, measured using the modified Ashworth scale (MAS), was significantly reduced after ESWT compared with that in the control group; however, it was sustained for only 1 month. After ESWT, significant increases in passive ankle range of motion (ROM) and plantar surface area in the standing position were observed compared with those in the control group and sustained for up to 3 months. Although spasticity measured using MAS was significantly reduced for only 1 month, improvement in spasticity-associated symptoms, such as ankle ROM and plantar surface area contacting the ground, persisted for over 3 months. ESWT appears to be a useful and effective therapeutic option for managing spasticity in patients with CP.

Comparison of Outcomes of Smile Reanimation Between Dual- Versus Single-Innervation Technique in Single-Stage Latissimus Dorsi Neuromuscular Transfer in Facial Paralysis Patients.

Background: Although a dual-innervation technique has emerged in single-stage functional latissimus dorsi (LD) muscle transfer for smile reanimation, its benefits over conventional techniques have not been elucidated. Objective: To compare outcomes of dual-innervation technique with those of single-innervation. Methods: Patients with facial palsy treated with single-stage functional LD muscle transfer were identified, and categorized into two groups: single and dual innervation. Outcomes were assessed using clinical examination based on the Terzis grading system and using automated software (Emotrics). Results: Fifty-nine patients (mean age 37.6 years; male/female 30/29) were analyzed, including 40 in single (35.1 years, 23/17) and 19 in dual-innervation group (43.0 years, 7/12), with a median follow-up of 34 months (range, 9-165) (single: 41.5, 12-165, dual: 23.0, 9-41). Tumor-related paralysis was the most common etiology in both groups (overall: 45.8%, single: 40.0%, dual: 57.9%). The dual group had a significantly higher rate of cases with Terzis grade IV or V postoperatively. In the Emotrics-based evaluation, the dual group exhibited significantly enhanced improvements in smile excursion in the dynamic state compared with the single. The degree of improvement in the resting state did not differ between groups. Conclusion: The dual-innervation technique might provide promising results in achieving enhanced smile excursion.

Incidence and Risk Factors of Cranial Nerve Palsy in Patients with Tuberculous Meningitis: A Retrospective Evaluation.

Tuberculous meningitis (TBM) is a common form of central nervous system (CNS) tuberculosis (TB). Cranial nerve palsy is a serious complication of TBM. Literature regarding this subject is still limited in China. This study evaluated the incidence of cranial nerve palsy in patients with TBM in South China, its association with the clinical forms of TB, and other patient characteristics. A retrospective chart review of patients with a diagnosis of TBM between January 2004 and December 2019 was conducted, and the demographic characteristics, clinical characteristics, and laboratory results of 114 patients were collected and followed up for 3 months. A multivariate logistic regression analysis model was used to explore the risk factors of cranial nerve palsy in patients with TBM. A total of 114 patients were enrolled in this study. Cranial nerve palsy was observed in approximately 38 (33.3%) of TBM patients. Among them, 13 (28.3%) had optic nerve palsy, 24 (52.2%) had oculomotor nerve palsy, 5 (10.9%) had abducens nerve palsy, 2 (4.3%) had auditory nerve palsy, 1 (2.2%) had glossopharyngeal nerve palsy, and 1 (2.2%) had vagus nerve palsy. Using logistic regression analysis, focal neurological deficit, extracranial TB and cerebrospinal fluid (CSF) total white cell count (WCC) were shown to be risk factors for cranial nerve palsy. The prevalence rate of cranial nerve palsy was 33.3% in patients with TBM. Focal neurological deficits, extracranial TB and CSF total WCC are important predictors of cranial nerve palsy in patients with TBM.

Clinical and biochemical features of hypokalemic paralysis: a study from rural Eastern India

BackgroundHypokalemic paralysis is characterized by episodic attacks of flaccid muscle weakness of variable duration and severity associated with hypokalemia. Overall, there is a scarcity of data regarding hypokalemic paralysis from Indian subcontinent particularly from rural areas.MethodsA total of 50 consecutive patients of hypokalemic paralysis who were admitted in our hospital were recruited in this study.ResultsFifty patients of hypokalemic paralysis were admitted to our department over a period of 4 years. Forty-two (84%) patients presented with classic acute onset quadriparesis, while eight patients had atypical presentation. Five patients had paraparesis, two had hemiparesis and one patient presented with isolated neck muscle weakness without any limb weakness. Thirty-two patients had primary hypokalemic periodic paralysis (HoPP) and 18 had secondary hypokalemic paralysis. There was no significant difference in severity of weakness (p = 0.53), number of episodes of weakness (p = 0.66) and serum CPK levels (p = 0.36) between primary and secondary hypokalemic paralysis. Secondary cases required significantly prolonged time for recovery as well as higher potassium supplements as compared to the primary HoPP. The severity of weakness of proximal muscles measured in MRC grading showed a significant correlation with serum potassium levels (p = 0.010), but did not show any correlation with CPK Levels (p = 0.86).ConclusionHypokalemic paralysis is an important cause of acute flaccid paralysis in the Emergency Room that often improves dramatically with potassium supplements. While secondary cases often require treatment of underlying etiology, primary hypokalemic paralysis often requires chronic treatment with acetazolamide and/or potassium-sparing diuretics.

Evaluation of Gastrocnemius Spasticity With Shear-Wave Elastography in Children with Cerebral Palsy after Botulinum Toxin Injection: Defining A Proper Position for Measurement

Aim: Cerebral Palsy (CP) is the most common neuromuscular disorder in children and it is characterized by a dysfunction in movement and posture. Botulinum toxin injection is a treatment method used for muscle spasticity in patients with CP. Elastography is a new method which is used for measuring muscle stiffness. This study aims to evaluate the gastrocnemius muscle stiffness in cerebral palsy patients before and after botulinum toxin injection by using the elastography method and contribute to the establishment of a treatment algorithm with a proper position for measurement.Materials and Method: The participants of this study were chosen from the patients of our hospital’s orthopaedics and traumatology department. Among the patients on whom botulinum injection to gastrocnemius muscle was planned, 30 patients were randomly selected. Elastography of both gastrocnemius muscles were taken before the injection of botulinum toxin, in the third week and third month after the injection. Simultaneously with the elastography, Modified Ashworth Scale (MAS) values were noted. In hemiparetic patients, contralateral legs were taken as the control group.Results: The elastographic values of the medial head of gastrocnemius when the knee is in extension and ankle in passive dorsiflexion, were found to be statistically significantly related (p&amp;lt;0.05) to the MAS values before botulinum toxin injection, third week and third month post-injection.Conclusion: Stiffness due to spasticity in gastrocnemius muscle in CP patients was demonstrated through elastographic evaluation. A correlation was found between clinical MAS values. The most proper position was in which the knee is fully extended and the ankle is passively dorsiflexed. Elastographic measurements may be able to be used in these patients as a method of diagnosis in the future and it will help to assess the effectiveness of the treatment after the injection of botulinum toxin.

Negative Air Environment-Induced Rehabilitation of Spasticity And Behavior During Physiotherapy in Cerebral Palsy Patients

Introduction: Negative air ions (NAIs) are beneficial in improving memory, anti-depressant effects, productivity, psychological health, and well-being by inducing alkalinity in the body. Cerebral Palsy (CP) is a neurological disorder that impairs movement and elicits behavioral issues like anxiety, anger, agitation, dependency on others, hyperactivity, incompatibility, and stubbornness. Such behaviors may hamper their cooperation or willingness for physiotherapy. Methodology: Evidence-based studies to support that NAIs can augment the rehabilitation of CP are scant so, the present study was designed to determine if exposure to NAIs can normalize behaviors and physical outcomes. Ethical approval was taken from IBC, University of Karachi followed by the consent of the participants and the Al Umeed Rehabilitation Association where the intervention study was conducted in 2021. CP-inflicted participants were randomly allocated to the control and intervention groups. Both groups continued their regular twice-a-week physiotherapy sessions, but the intervention group also received 40-minute exposure to 10000 negative ions/cm3 for 6 weeks. Outcomes were assessed using a researcher-designed physiotherapist reporting questionnaire and Modified Ashworth Scale. Results: Analysis using SPSS v.28 demonstrated significant improvement in calmness, cooperation, physical condition, and willingness for physiotherapy along with minimal alleviation of spasticity. The possible role of neuronal pathways, synaptic response, and neurotransmitters such as acetylcholine, dopamine, gamma-aminobutyric acid, and serotonin have been discussed. Conclusion: The study concludes that NAIs may alleviate spasticity and normalize behaviors during physiotherapy sessions. We suggest the inclusion of this novel intervention in the multidisciplinary rehabilitation plan after going through the second and third-phase clinical trials.

Automatic part segmentation of facial anatomies using geometric deep learning toward a computer-aided facial rehabilitation

Detection, identification, and segmentation of facial landmarks and anatomies play an essential role in the automatic reconstruction of patient specific model of the human head for facial diagnosis, monitoring, and rehabilitation. The objective of the present study was to apply geometric deep learning to perform part segmentation on the human face to automatically segment facial anatomies from a 3D point set.A database of Computed Tomography images of 333 subjects was reconstructed. Labels of facial anatomies (eyes, nose, and mouth) were manually performed. Two state-of-the-art geometric deep learning models (PointNet++ and PointCNN) were implemented and evaluated. Then, the best model was applied to perform part segmentation on new Kinect-driven face data of healthy subjects and facial palsy patients. Accuracy and Intersection over Union (IoU) were used as evaluation metrics.An accuracy level of 99.19% and an IoU of 89.09% are obtained for the CT database using the PointNet++ model. Regarding the use of the PointCNN model, an accuracy level of 98.43 and an IoU of 78.33 were obtained. An accuracy range of [81.45%–92.09%] and [81.05%–84.08%] was obtained by using PointNet++ model on Kinect data for healthy subjects and facial palsy patients respectively.This study suggested that geometric deep learning can be used for automatic segmentation of facial anatomies from a 3D data set. The obtained outcomes confirmed the accuracy of PointNet++ and PointCNN architectures. As perspectives, the proposed method will be implemented into an available computer vision system for facial monitoring and rehabilitation.

A Multicentre Randomized Controlled Clinical Study of Cross Electro-Nape-Acupuncture (CENA) for the Treatment of Pseudobulbar Palsy in Patients with Tracheotomy Intubation for Severe Cerebral Haemorrhage.

The objective is to evaluate the clinical efficacy of cross electro-nape-acupuncture (CENA) in the treatment of pseudobulbar palsy in patients with tracheotomy intubation for severe cerebral haemorrhage and to provide an innovative acupuncture method for the treatment of such patients. A total of 126 patients from six trial centres who met the inclusion criteria were randomly divided into three groups according to the random number table method in the ratio of 1 : 1 : 1, with 42 patients in each group, and the three groups were divided into CENA group, electro-acupuncture group, and acupuncture group. Each group's acupuncture treatment lasted for 30 minutes, and the needles were removed at the end of the treatment. Acupuncture was performed once a week on Sunday only and twice a day from Monday to Saturday, a total of 4 weeks of treatment. The SWT, FDA, ChSWAL-QOL, and TCRGS scores of the three groups of patients before and after treatment were compared to evaluate the effect of CENA on remodelling the function of swallowing reflex and cough reflex and promoting the recovery of dysarthria and swallowing quality of life in pseudobulbar palsy in patients with tracheotomy intubation for severe cerebral haemorrhage. After treatment, the WST and TCRGS grade scores decreased and the FDA and ChSWAL-QOL scores increased significantly in all three groups compared with the pretreatment scores and were statistically significant. There was a significant difference between the three groups for these four indicators after treatment; the comparison between groups showed significant differences in the CENA group compared to the electro-acupuncture and acupuncture groups. The efficiency of the CENA group was significantly better than that of the electro-acupuncture and acupuncture groups. Compared with the acupuncture and electro-acupuncture groups, the CENA could better promote the remodelling of swallowing function and cough reflex function, promote the recovery of dysarthria, and better improve the quality of life of patients with pseudobulbar palsy from tracheotomy intubation in severe cerebral haemorrhage.