In this paper, we investigate the acceleration properties of fine-grain parallel large-scale MOSFET circuit simulation using multi-core CPU. Several CPU have been tested for understanding maximum possible accelerations. A parallel circuit simulator, MOSTIME, is used to simulate experimental circuits. Performing tests on CPU and MOSTIME, we find that more advanced accelerations on large-scale fine-grain parallel circuit simulation would rely on time-saving software techniques and GPU (Graphic Processing Unit) cards. A newly implemented time-saving technique for MOSTIME has been tested to show promising effects.