Malaria, which is still endemic in Papua Indonesia, especially Mimika Regency, has the classic issue of low adherence to antimalarial medication necessitates the use of a technological approach through telenursing, which includes reminders and self-reporting, allowing for optimal monitoring of adherence. To determine the effect of web application-based telenursing on adherence to antimalarial medication. This study used a quasi-experimental design with a pre-post test only approach. The instrument used was the Morisky Medication Adherence Scale-8 (MMAS). The sample consisted of 42 respondents per group. The analysis of medication adherence showed a significant difference between pre- and post-treatment in the intervention group, with a p-value of 0.000 (p-value < 0.05). Additionally, post-hoc pairwise comparisons showed that in the control group, a significant p-value of 0.000 was only found between day 15 and day 3, while in the intervention group, significant p-values of 0.000 were found at every time point. Web application-based telenursing has been proven to significantly affect adherence to antimalarial medication.
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