Papillary Fragments Research Articles

Correlation between proliferating index and prognostic factors in papillary cystic tumors of the pancreas

Fifteen cases of papillary cystic tumor of the pancreas (PCTP) were studied (14 female patients, one male patient; mean age: 23.5 years). Most tumors developed in the head of the pancreas as a well circumscribed large mass. The tumor had a mean diameter of 6.7 cm(range; 2 to 15 cm). Histopathologically abundant delicate papillary fragments, monomorphic tumor cells and degenerative changes of the solid area of the tumor were characteristic. All but two cases had completely circumscribed capsules. Two cases had duodenal invasion; one of all cases had cul de sac metastasis. Compared with 12 non-aggressive tumors, the aggressive cases had larger tumor size (more than 9 cm) with a thicker capsule (more than 2 mm). In studies to investigate the prognostic index using nucleolar organizing region (NOR), proliferating cell nuclear antigen (PCNA) and flow cytometry as well as nuclear grade and mitotic index, we could not find the useful parameter to detect the malignant potential of PCTP. In the flow cytometric analysis of cellular DNA contents, two invasive cases and the only one case of the male patient among the non-aggressive group were aneuploid. In conclusion, although it is hard to predict the prognosis by microscopic findings only, those with a thick capsule and aneuploidy tend to be related to malignant potential.

Morphologic and morphometric features of low grade serous tumours of the ovary.

Peritoneal washings from twelve patients with serous tumours of the ovary were studied. Six patients had borderline serous tumours (BSTs), and six had grade one adenocarcinomas. Papanicolaou stained slides were assessed for nine morphologic parameters; background, single cells, size of papillary fragments, contour of papillary fragments, psamomma bodies, cytoplasmic vacuoles, nuclear pleomorphism, nuclear membrane contour, and nucleoli. The slides were destained and restained by the Feulgen method for assessment, with a computer based image analysis system (CAS100, Cell Analysis Systems, Inc., Elmhurst, IL), of DNA content, nuclear size, and nuclear roundness. The contour of the papillary fragments (P = 0.004) and the presence of nuclear pleomorphism (0.019) were distinguishing characteristics. All six BSTs were diploid while three of the six adenocarcinomas had aneuploidy. Two exhibited polyploid DNA distribution and one exhibited diploid DNA distribution. The pooled data for the nuclear size and roundness showed little difference in the modal values, although the nuclei of the adenocarcinoma cells were slightly larger than those of the borderline cells (54 sq. microns vs. 46 sw. microns). However, the coefficients of variation (CVs) for each of these parameters were larger in the adenocarcinoma group than in the borderline group (59.7 vs. 36.4% for size and 33.5 vs. 17.8% for roundness). Although the sample size is small, the data suggest that aneuploidy is rare in borderline tumours. In addition, the presence of papillary groups with irregular contours and nuclear pleomorphism (reflected in higher CVs for nuclear size and roundness) both occur more commonly in adenocarcinomas than in borderline tumours and may be of predictive value in distinguishing the two groups.

Morphologic and morphometric features of low grade serous tumors of the ovary

Peritoneal washings of 12 patients with serous tumors of the ovary were studied. Six patients had borderline tumors, and six had grade one adenocarcinomas. Papanicolai stained slides were assessed for nine morpholigic parameters: background, single cells, papillary fragments, contour of papillary fragments, psamnioma bodies, cytoplasmic vacuoles, nuclear pleomorphism, nuclear membrane contour, and nucleoli. The slides were destained and restained by the Feulgen method, for assessment with a computer based image analysis system (CAS100, Cell Analysis Systems, Inc., Lombard, IL), of DNA content, nuclear size, and nuclear roundness. The contour of the papillary fragments (p=0.004) and the presence of nuclear pleomorphism (p=0.019) were distinguishing characteristics. All six borderline tumors were diploid while three of six adenocarcinomas had aneuploidy. The pooled data for the nuclear size and roundness showed little difference in the modal values, although the nuclei of the adenocarcinoma cells were slightly larger than those of the borderline cells (54 sq. microns vs 46 sq. microns). However, the coefficients of variation (CVs) for each of these parameters were larger In the adenocarcinoma group than in the borderline group (59.7% vs 36.4 % for size and 33.5% vs 17.8% for roundness) Although the sample size is small the data suggest that aneuploidy is rare in borderline tumors. In addition the presence of papillary groups with irregular contours, and nuclear pleomorphism (reflected in higher CVs for nuclear size and roundness) both occur more commonly in adenocarcinomas than in borderline tumors and may be of predictive value in distinguishing the two groups.

Nuclear grooves: A useful criterion in the cytopathologic diagnosis of papillary thyroid carcinoma

A recent report emphasized the usefulness of the grooved nucleus as a diagnostic criterion of papillary thyroid carcinoma (PTC) in histopathologic material. The present study was undertaken to evaluate whether grooved nuclei can serve as an additional diagnostic criterion for PTC in cytologic material obtained by fine-needle aspiration (FNA). Slides from 124 consecutive thyroid FNAs were reviewed. Specimens included 11 PTCs, one follicular carcinoma, six follicular adenomas, eight follicular neoplasms not otherwise specified, 10 cases of chronic thyroiditis, and 88 colloid nodules/adenomatous goiters. Among the PTC cases, grooved nuclei were found in all 11 (100%), intranuclear inclusions in nine (82%), papillary fragments in seven (64%), and psammoma bodies in two (18%). Nuclear grooves were also observed in two of the 113 non-PTC cases (1.8%), both of which were colloid nodules, one with extensive Hurthle-cell change. The grooved nuclei were best identified on Papanicolaou-stained material. They were inconspicuous and difficult to identify in air-dried Diff-Quik-stained material. It appears that the recognition of grooved nuclei among tumor cells is a valuable diagnostic feature of PTC in cytologic material stained with polychromatic Papanicolaou stain.

A PITFALL IN THE CYTODIAGNOSIS OF SPUTUM OF ASTHMATICS.

The sputum of an asthmatic often contains large, well-circumscribed clusters of benign columnar epithelial cells which can be misinterpreted as papillary fragments of an adenocarcinoma. Their presence is a manifestation of the excessive shedding of the mucosa of the lower respiratory tract accompanying an attack of bronchial asthma. These clusters are illustrated and compared with clusters of adenocarcinoma cells. To discriminate between the two types of cluster may be difficult and it is therefore important for the cytologist to know when a sputum is from an asthmatic.

On renal papillary necrosis with special reference to the diagnostic importance of papillary fragments in the urine, therapy (i. a. artificial kidney) and prognosis, Report of 75 cases, including 12 with papillary fragments in the urine.

Acta Medica ScandinavicaVolume 167, Issue 5 p. 319-330 On Renal Papillary Necrosis with Special Reference to the Diagnostic Importance of Papillary Fragments in the Urine, Therapy (i. a. Artificial Kidney) and Prognosis Report of 75 cases, including 12 with papillary fragments in the urine Tore Lindholm, Tore Lindholm University Medical Clinic (Renal Clinic), Lund, SwedenSearch for more papers by this author Tore Lindholm, Tore Lindholm University Medical Clinic (Renal Clinic), Lund, SwedenSearch for more papers by this author First published: January/December 1960 https://doi.org/10.1111/j.0954-6820.1960.tb03554.xCitations: 11AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Citing Literature Volume167, Issue5January/December 1960Pages 319-330 RelatedInformation