Panoramic Radiographs Research Articles

Unsupervised few shot learning architecture for diagnosis of periodontal disease in dental panoramic radiographs.

In the domain of medical imaging, the advent of deep learning has marked a significant progression, particularly in the nuanced area of periodontal disease diagnosis. This study specifically targets the prevalent issue of scarce labeled data in medical imaging. We introduce a novel unsupervised few-shot learning algorithm, meticulously crafted for classifying periodontal diseases using a limited collection of dental panoramic radiographs. Our method leverages UNet architecture for generating regions of interest (RoI) from radiographs, which are then processed through a Convolutional Variational Autoencoder (CVAE). This approach is pivotal in extracting critical latent features, subsequently clustered using an advanced algorithm. This clustering is key in our methodology, enabling the assignment of labels to images indicative of periodontal diseases, thus circumventing the challenges posed by limited datasets. Our validation process, involving a comparative analysis with traditional supervised learning and standard autoencoder-based clustering, demonstrates a marked improvement in both diagnostic accuracy and efficiency. For three real-world validation datasets, our UNet-CVAE architecture achieved up to average 14% higher accuracy compared to state-of-the-art supervised models including the vision transformer model when trained with 100 labeled images. This study not only highlights the capability of unsupervised learning in overcoming data limitations but also sets a new benchmark for diagnostic methodologies in medical AI, potentially transforming practices in data-constrained scenarios.

The Relationship between Impacted Mandibular Third Molar and Mandibular Canal on Orthopantomogram – A Retrospective Study

Background: Surgical removal of the impacted lower third molar teeth require thorough investigations and assessment, one of these very important investigations is orthopantomogram (OPG) which is the primary assessment method, to determine the relationship between impacted mandibular third molar and mandibular canal. The study aims to determine the relationship between impacted mandibular third molar and mandibular canal on orthopantomogram. Materials and methods: A retrospective of 300 OPGs out of 947 OPG were selected using simple random sampling method. Rood’s criteria was used in assessing the relationship between the apex of the roots and upper border of the inferior alveolar canal. Statistical analysis was performed to assess the relationship between the canal and the impacted lower third molar in relation to the age ,gender and type of impaction.Results: From 300 OPG, 473 impacted teeth were identified, the relation showed, the highest percentage was superimposed with 47.3%, followed by close contact (35.7%), and only 21.7% of the impacted teeth examined has distance between the roots and the upper border of mandibular canal.Conclussion:Mesioangular impaction has higher percentage of superimposition with the mandibular canal with the higher percentage of female58% to male42% ratio.

Maxillary Sinus Floor and Posterior Root Apices Relationship in Egyptian Population: A Cross-sectional Panoramic Radiograph Analysis

Maxillary Sinus Floor and Posterior Root Apices Relationship in Egyptian Population: A Cross-sectional Panoramic Radiograph Analysis

Mandibular morphology in schizophrenia patients compared with non-psychiatric controls using digital panoramic radiography: a retrospective cross-sectional study from Istanbul, Türkiye

BackgroundSchizophrenia is a chronic severe mental disorder characterized by impairment in cognition, emotion, perception, and other aspects of behavior. In light of the association of craniofacial dysmorphology with schizophrenia, mandibular morphology may provide clues about the role of neurodevelopment in the pathophysiology of schizophrenia. This retrospective cross-sectional study aimed to compare the mandibular morphology of patients with schizophrenia with controls using digital panoramic radiography (DPR).Methods302 recorded diagnostic panoramic images obtained from 143 schizophrenia patients (98 males, 45 females), and 159 controls (73 males, 86 females), aged 18–45 years, were evaluated. Seven mandibular measurements consisting of ramus height, condylar height, gonial angle, antegonial angle, antegonial notch depth, ramal notch depth and bigonial width were measured from the DPRs in a double-blinded manner. Bivariate comparisons were carried out using the Independent t-test and Mann–Whitney U test. Logistic regression analysis was used for multivariate comparisons.ResultsLinear measurements were higher while angular measurements were lower in schizophrenia patients. Regression analyses indicated that female patients had greater ramus height (OR = 1.243; P = 0.001), condylar height (OR = 1.463; P = 0.048) and bigonial width (OR = 1.082; P < 0.001); male patients had greater ramus heights (OR = 1.216; P = 0.001) and bigonial width (OR = 1.076; P < 0.001) as well as lower antegonial angle (OR = 0.908; P = 0.012) compared to their respective controls.ConclusionQuantitative differences in mandibular morphology in schizophrenia patients versus controls deserve attention and corroborate with the concept of abnormal neurodevelopment in schizophrenia.

Investigation of genetic polymorphisms in genes encoding growth factors and dental pulp calcification in orthodontic patients

Background and objectivesPulp calcification is associated with many factors and triggers, including individual genetic predisposition and orthodontic forces. This study aimed to investigate whether genetic polymorphisms in epidermal growth factor (EGF), epidermal growth factor receptor (EGFR1), transforming growth factor-beta 1 (TGFβ1), and transforming growth factor-beta receptor 2 (TGFβR2) are associated with a risk of dental pulp calcifications in orthodontic patients. Materials and methodsDigital orthopantomography (OPG) and genomic DNA from 132 patients were analyzed in this cross-sectional study. Pulp calcification was observed in the maxillary and mandibular first molars. Genomic DNA extracted from saliva cells was used to genotype eight genetic polymorphisms using real-time polymerase chain reaction: EGF (rs2237051 and rs4444903), EGFR (rs2227983 and rs763317), TGFβ1 (rs1800469 and rs4803455), and TGFβR2 (rs3087465 and rs764522). The association between pulp calcification and genetic polymorphisms was analyzed using allelic and genotypic distributions, and haplotype frequencies (P < 0.05). ResultsThe prevalence of pulp calcification was 42.4 % in 490 molars. Genotypic analysis and allelic distribution showed no statistically significant association between the evaluated growth factors and molar calcification (P > 0.05). No haplotype combinations showed a statistically significant difference (P > 0.05). ConclusionThe genetic polymorphisms investigated were not associated with dental pulp calcification in orthodontic patients. Further studies should investigate other polymorphisms in genes encoding growth factors.

Towards dental diagnostic systems: Synergizing wavelet transform with generative adversarial networks for enhanced image data fusion

The advent of precision diagnostics in pediatric dentistry is shifting towards ensuring early detection of dental diseases, a critical factor in safeguarding the oral health of the younger population. In this study, an innovative approach is introduced, wherein Discrete Wavelet Transform (DWT) and Generative Adversarial Networks (GANs) are synergized within an Image Data Fusion (IDF) framework to enhance the accuracy of dental disease diagnosis through dental diagnostic systems. Dental panoramic radiographs from pediatric patients were utilized to demonstrate how the integration of DWT and GANs can significantly improve the informativeness of dental images. In the IDF process, the original images, GAN-augmented images, and wavelet-transformed images are combined to create a comprehensive dataset. DWT was employed for the decomposition of images into frequency components to enhance the visibility of subtle pathological features. Simultaneously, GANs were used to augment the dataset with high-quality, synthetic radiographic images indistinguishable from real ones, to provide robust data training. These integrated images are then fed into an Artificial Neural Network (ANN) for the classification of dental diseases. The utilization of the ANN in this context demonstrates the system's robustness and culminates in achieving an unprecedented accuracy rate of 0.897, 0.905 precision, recall of 0.897, and specificity of 0.968. Additionally, this study explores the feasibility of embedding the diagnostic system into dental X-ray scanners by leveraging lightweight models and cloud-based solutions to minimize resource constraints. Such integration is posited to revolutionize dental care by providing real-time, accurate disease detection capabilities, which significantly reduces diagnostical delays and enhances treatment outcomes.

A Deep-learning System for Diagnosing Ectopic Eruption

Objectives: To construct a diagnostic model for mixed dentition using a multistage deep-learning network to predict potential ectopic eruption in permanent teeth by integrating dentition segmentation into the process of automatic classification of dental development stages.Methods: A database was established by reviewing 1576 anonymous panoramic radiographs of children aged 6–12 years, collected at the Stomatology Hospital, xxxxxx. These radiographs were categorised as normal or ectopic eruption, with expert diagnoses serving as a benchmark for training and evaluating artificial intelligence (AI) models. Furthermore, tooth boundaries and dental development stages were manually annotated by three pediatric dentistry experts. The dataset was split into training, validation, and test sets at an 8:1:1 ratio.Results: The diagnostic performance of the deep-learning model was rigorously evaluated. The model demonstrated accuracy in tooth segmentation, with Intersection over Union, precision, sensitivity, and F1 scores of 0.959, 0.993, 0.966, and 0.979, respectively. Furthermore, its ability to identify tooth ectopic eruptions on panoramic radiographs, when compared to evaluations by three dentists. Based on McNemar's test, the model's specificity and accuracy in identifying ectopic tooth eruptions on the test dataset surpassed that of Dentist 1 (P < 0.05), while no significant difference was observed compared to the other two dentists. Besides, the deep learning model also showed its potential in classifying dental development stages, as tested against three different standards.Conclusions: The adaptability of the AI-enabled model in this study was demonstrated across multiple scenarios, with clinical validation highlighting its efficacy in diagnosing ectopic eruptions using a multistage deep-learning approach.Clinical Significance: Our findings provide new insights and technical support for the prevention and treatment of abnormal tooth eruption, laying the groundwork for predictive models for other prevalent pediatric dentistry conditions.

Diagnostic Charting on Panoramic Radiographs: An Artificial Intelligence Study

Diagnostic Charting on Panoramic Radiographs: An Artificial Intelligence Study

Evaluation of mandibular bone structure changes in phenylketonuria patients through fractal analysis and radiomorphometric indices

ObjectivesThe aim of this study was to evaluate the effect of phenylketonuria (PKU) on mandibular bone structure by comparing the bone of PKU patients with healthy controls using fractal analysis and the radiomorphometric indices of mandibular cortical width (MCW) and mandibular cortical index (MCI). Study DesignIn total, 32 patients with PKU were analyzed and compared with the control patients. Regions of interest in panoramic radiographs were selected and the fractal dimension (FD) obtained from fractal analysis was calculated. MCW was defined as the cortical thickness of the inferior border of the mandible at the level of the mental foramen. MCI classified the endosteal edge of the mandibular cortex as C1: straight and sharp, C2: the presence lacunar resorption spaces, and C3: distinctly porous and severely eroded. The significance level was P<0.05. ResultsAll FD and MCW values were significantly lower in the PKU patients. The prevalence of C1 was significantly lower and prevalence of C2 was significantly higher in the PKU group. ConclusionThe differences in fractal dimension and radiomorphometric indices between patients with PKU and healthy controls may indicate a potential impact of PKU on mandibular bone structure.

Evaluation Of Lateral Root Resorption In Maxillary Teeth Among First Premolar Extraction Cases After Space Closure- A CBCT Study

Background: Orthodontic treatment usually involves usage of light continuous forces but when heavy forces are used it leads to apical root resorption. External apical root resorption refers to reduction in root structure involving the apices. This resorption is of transient inflammatory type. 2D images are commonly used for diagnostic purposes in orthodontics but it cannot detect root resorption on lingual or buccal surfaces thus cannot measure the volume of root loss. Cone beam computed tomography which can provide 3D images was introduced in late 1990s. Images provided by CBCT are more more accurate than panoramic and periapical radiographs . Therefore in this study , CBCT is used to evaluate lateral root resorption in maxillary teeth after after space closure among first premolar extraction cases . Materials and Methods: CBCTs of 20 patients fulfilling inclusion and exclusion criteria were taken before the start of orthodontic treatment and after space closure. Post treatment root width was substracted from the pre treatment root width at three levels from CEJ (3mm,6mm,9mm). The normality test (Shapiro-Wilk Test) was performed to analyze the data, and the results were expressed as frequency with percentage and mean with standard deviation. Difference between means were assessed using paired t test for before and after the procedure. All the statistical analyses were carried out at a 5% level of significance, and results with a P value &lt; 0.05 were considered statistically significant. Results: Considering all the three levels the least tooth resorption was observed in the case of central incisor (0.1750 ± 0.0444, p &lt;0.001) and highest in the canine tooth (5.900± 0.0000, p &lt;0.001) . Conclusion: When root resorption is detected, it is recommended to pause the treatment for about 6 months to allow for root repair. Intermittent forces, which provide rest periods between applications, are more tissuefriendly and can help reduce the risk of further resorption

Clinical Image Quality Evaluation For Panoramic Radiography: Clinical Audit

Clinical Image Quality Evaluation For Panoramic Radiography: Clinical Audit

Patterns of mandibular third molar impaction and its relationship with distal caries in the adjacent mandibular second molars: A retrospective study

BackgroundImpacted third molars can cause significant challenges for dental health. While many of these impacted teeth remain asymptomatic, they can lead to dental caries. ObjectiveTo investigate the patterns of mandibular third molar impaction and its relationship with the occurrence of caries in the adjacent mandibular second molars. Materials and MethodsThis study assessed the dental panoramic radiographs of 1591 participants who visited the Department of Oral and Maxillofacial Surgery at the Dental Teaching Hospital at Umm Al-Qura University between 2022 and 2024. The presence of distal caries in the adjacent mandibular second molars was assessed and compared across the different impaction patterns, considering both age and gender. ResultsThe results showed that 29.22 % of the patients had impacted mandibular third molars. The most common patterns of impacted mandibular third molar angulation were mesioangular in the females and horizontal in the males. The majority of these impacted third molars were level A and class I (as per the Pell and Gregory classification).One hundred and eighty-three (39.35 %) of the impacted mandibular third molars had associated carious lesions, with 89 showing distal caries in the adjacent mandibular second molar and 18 showing caries in the third molar itself. The carious lesions were most commonly found in cases of mesioangular, level A, and class I impaction patterns (p < 0.05). ConclusionThe findings of this study shed light to the high prevalence of carious lesions associated with impacted mandibular third molar, especially in cases of mesioangular, level A, and class I impaction patterns. These findings highlight the importance of careful monitoring of impacted third molars to prevent the development of caries in the adjacent teeth.

Fractal Analysis of Mandible in Panoramic Radiographs of Patients Received Radiotherapy for Nasopharyngeal Carcinoma

PurposeThis study aimed to assess the impact of radiotherapy on the internal structure complexity of mandibular cortical and trabecular bone and to determine the duration required for a return to healthy values post-radiotherapy. Materials and MethodsPanoramic radiographs from patients undergoing radiotherapy for nasopharyngeal carcinoma were analyzed before and after treatment. Four groups were formed based on post-radiotherapy radiography timing (0-6 months, 6-12 months, 12-24 months, and 24-36 months), comprising a total of 59 cases and 118 radiographs. Fractal analysis was conducted on four bilateral regions (ROI) in both trabecular and cortical bone on each radiograph. Additionally, measurements of inferior alveolar canal width and mandibular cortical width were performed. Mean and maximum radiation dose values to the mandible were measured, and their correlation with changes in fractal dimension, inferior alveolar canal width, and mandibular cortical width values was assessed. ResultsFractal dimension values in regions over trabecular bone showed a statistically significant decrease in all groups, although no significant difference was observed among the four groups. In ROI-4 from cortical bone, a significant fractal dimension decrease was noted in all groups except the 0-6 month group. The magnitude of fractal dimension decrease was higher in the 12-24 and 24-36 month groups compared to the 0-6 month group. inferior alveolar canal width and mandibular cortical width values significantly decreased post-radiotherapy in all groups, with a consistent decrease across the groups. ConclusionsRadiotherapy induces a reduction in the internal complexity of trabecular and cortical bone structures in the mandible. Osteoradionecrosis risk persists even three years post-radiotherapy, suggesting a cautious approach to interventional procedures on the bone.

Clinical knowledge-guided hybrid classification network for automatic periodontal disease diagnosis in X-ray image

Accurate classification of periodontal disease through panoramic X-ray images carries immense clinical importance for effective diagnosis and treatment. Recent methodologies attempt to classify periodontal diseases from X-ray images by estimating bone loss within these images, supervised by manual radiographic annotations for segmentation or keypoint detection. However, these annotations often lack consistency with the clinical gold standard of probing measurements, potentially causing measurement inaccuracy and leading to unstable classifications. Additionally, the diagnosis of periodontal disease necessitates exceptional sensitivity. To address these challenges, we introduce HC-Net, an innovative hybrid classification framework devised for accurately classifying periodontal disease from X-ray images. This framework comprises three main components: tooth-level classification, patient-level classification, and a learnable adaptive noisy-OR gate. In the tooth-level classification, we initially employ instance segmentation to individually identify each tooth, followed by tooth-level periodontal disease classification. For patient-level classification, we utilize a multi-task strategy to concurrently learn patient-level classification and a Classification Activation Map (CAM) that signifies the confidence of local lesion areas within the panoramic X-ray image. Eventually, our adaptive noisy-OR gate acquires a hybrid classification by amalgamating predictions from both levels. In particular, we incorporate clinical knowledge into the workflows used by professional dentists, targeting the enhanced handling of sensitivity of periodontal disease diagnosis. Extensive empirical testing on a dataset amassed from real-world clinics demonstrates that our proposed HC-Net achieves unparalleled performance in periodontal disease classification, exhibiting substantial potential for practical application.

Comparative Evaluation of Condylar Guidance Obtained by Digital Panoramic Radiographic Images Using Two Different Interocclusal Recording Material During Jaw Relation in Completely Edentulous Patients: An In Vivo Study.

Objective To compare the condylar guidance value obtained during jaw relation by two different interocclusal recording materials to that obtained from OPG (Orthopantomogram). Materials and methods Two different interocclusal recording materials were used, namely bite registration wax (reinforced wax, by MAARC Dental Company) and bite registration paste (jet bite, coltene) for interocclusal records during jaw relations. An OPG is shot prior to the treatment, and horizontal condylar guidance (HCG) is traced joining the bony landmarks in a completely edentulous patient seeking complete denture treatment. All the conventional steps for complete denture fabrication up to jaw relation are performed. A facebow transfer is done on a Hanau H2 articulator, and height tracers (extra oral tracing devices) are attached. After satisfactory training, the tracing is performed by the patient, and the interocclusal records are obtained. The articulator is programmed to obtain the value of HCG using protrusive records, which are then compared to the value obtained from OPG. Statistics were carried out to determine angles. Followed by statistical analysis with Pearson correlation to analyze the results (α = 0.01). Results A substantial relationship was discovered between the horizontal condylar inclination between two interocclusal recording materials and the corresponding OPG for both the right (p = 0.0015) and left (p = 0.0007) sides. Conclusion The condylar guidance obtained with jet bite was closer than the condylar guidance value obtained with reinforced wax when compared with the horizontal condylar inclination obtained in OPG by tracing with a mean difference of 10° for polyvinyl siloxane and 20° for reinforced wax in seven subjects evaluated.

Determination of Mandibular Morphology in a Turkish Population With Bipolar I Disorder Using Panoramic Radiography.

The presence of specific craniofacial deviations may be evidence of abnormal early brain development in bipolar disorder (BD). This study aimed to compare mandibular morphology in patients with BD versus nonpsychiatric controls using panoramic radiography. A total of 215 recorded images, 70 patients with BD and 145 controls, were evaluated. Seven mandibular parameters of the ramus height (RH), condylar height (CH), gonial angle (GA), antegonial angle (AGA), antegonial notch depth (AND), ramal notch depth (RND), and bigonial width (BGW) were measured in a blinded manner. Group analysis was conducted separately for males and females. The univariate comparisons showed increased values in RH, CH, AND, RND, and BGW and decreased values in GA in males with BD compared with male controls. In addition, females with BD had higher RH, CH, RND, and BGW values in comparison to female controls. The differences were statistically significant. Data from multivariate analyses revealed that increases in RH and BGW values in both sexes were significant predictive variables that distinguished patients with BD from controls. Moreover, deeper AND was the most prominent predictor that distinguished male patients with BD from male controls. The identification of subtle changes in mandibular measurements is consistent with the notion of impaired neurodevelopment in BD.

Evaluación tomográfica del mixoma odontogénico en maxilar superior. Reporte de caso y revisión de la literatura

Odontogenic myxoma (OM) is a slow-growing, painless, aggressive and non-metastatic central jaw tumor of mesenchymal origin. Radiographically, it can vary from a unilocular radiolucent lesion to a multilocular lesion with well-defined or diffuse margins. The aim of this paper is to recognize the radiographic and tomographic characteristics of OM in a patient who attended the Dental Clinic of the Faculty of Dentistry of the Universidad Nacional Mayor de San Marcos in Lima-Peru. Case presentation: 86 year old male patient, who in the panoramic radiography indicated for his oral rehabilitation, a unilocular radiolucent image was found in the anterosuperior area with partially defined limits, corticalized edges and oval shape. In the volumetric tomography there was evidence of thinning and erosion of both bone tables, thinning of the floor of the nasal cavity. The radiolucent image seems to havean extension close to the alveolar ridge. In adition, there was an effacement of the cortices of the nasopalatine duct. The lesion was enucleated and an anatomopathological examination was performed. Diagnosis was odontogenic myxoma. The patient was evaluated at one year and six months with satisfactory results. The wide variety of radiographic characteristics of odontogenic myxoma leads us to think of a large number of differential diagnoses, being the histological evaluation together with the imaging analysis the ones that provide a definitive diagnosis. Although the anterosuperior area is the least common for its presentation, radiolucent images in this area should be considered as possible odontogenic myxomas, since this condition is more frequent in latín race.

Prevalence and pattern of third molars impaction in a large Yemeni sample: a retrospective study.

The prevalence of teeth impaction varies substantially between different populations, and the impaction of third molars is the most commonly recorded. This study aimed to explore the prevalence and pattern of the third molars impactions among Yemeni population. This was a retrospective radiographic study conducted in Yemen between 2022 and 2023. The digital panoramic radiographs were collected from two major X-ray centers in Yemen. The angular position and depth of the impacted third molars were assessed according to the classifications of Winter and of Pell and Gregory, respectively. All radiographs were evaluated twice by one investigator in a two-week interval, and Kappa test was used for intra-rater reliability. Gender-wise differences, differences between both sides, and differences between maxilla and mandible were analyzed using Chi-squared tes with odds ratio (OR) for the risk of impaction. A P-value < 0.05 was considered significant. Panoramic radiographs of 6338 individuals were included. Their mean age was 35.1 ± 13.3 years andand 63.9% were females. A total of 25,352 sites (quadrants) were screened for the presence of thirds molars. Among which, 14,003 third molars (55.3%) were present in one or more sites. There were 1440 individuals (23%) with a total of 2828 impacted third molars (20% of the existing third molars). Females were less likely to have third molar impaction (OR = 0.46, CI95% = 0.4-0.52). Impaction of the mandibular third molars was significantly more frequent than the maxillary ones (OR = 1.15, CI95% = 1.04-1.26; P = 0.005). Horizontal and mesioangular impactions were statistically more frequent in the lower molars compared to the upper ones (P < 0.001 each). Contrastingly, vertical (P = 0.015), distoangular, and other impactions (P < 0.001 each)were statistically more frequent in the maxilla. Levels A and B were more frequent in the lower third molars, while level C was predominating in the upper molars (P < 0.001 each). The prevalence of third molars impaction is more frequent in males and mandibular arch. The angulation and level of impaction seem to be more complicated in the maxillary arch.

Radiographic identification of symptomless mandibular third molars without clinical pericoronitis

ObjectivesThe aim was to identify radiographic characteristics of mandibular third molars in young adults without symptoms or clinical signs of pericoronal infection.Materials and methodsAn existing cross-sectional material, including records from clinical oral examination and panoramic radiographs (PANs) of university students, was submitted to retrospective analysis. The outcome variable was a symptomless and clinically pericoronitis-free mandibular third molar. Predictor variables for the third molar were clinical eruption level, pathological signs in the follicle, marginal bone level, radiographic depth in bone, inclination, stage of root development, and available space for eruption. Statistics included χ2 and Mann-Whitney U tests.ResultsAnalysis included 345 mandibular third molars in 189 participants (20% men, 80% women; mean age 20.7 years; SD ± 0.6). Symptomless and clinically pericoronitis-free mandibular third molars were characterized as follows: clinically unerupted in 78% of teeth, associated with reduced marginal bone level in 70%, located deeper in the bone in 87%, mesially inclined in 73%, and stage of root development incomplete in 68% (p ≤ 0.001 for all).ConclusionsRadiographic characteristics of symptomless mandibular third molars without clinical pericoronitis in young adults can be assessed from a PAN with 68–87% certainty.Clinical relevanceThese findings may prove useful when trying to exclude non-pathological mandibular third molars from diseased teeth.

Accuracy of Mandibular Foramen Localization Using Digital Orthopantomogram (OPG) in Middle Eastern Population.

Locating the mandibular foramen (MF) through imaging is clinically important for inferior alveolar nerve (IAN) anesthesia and mandibular ramus osteotomies. Although cone-beam computed tomography (CBCT) is superior in imaging the mandible, an orthopantomogram (OPG) is preferred for its ease of use and availability. Therefore, the present study aimed to evaluate the accuracy of digital OPG in localizing the MF, in a subset of the Middle Eastern population. Radiographic images (OPG and CBCT) of selected patients (adults, dentulous and no mandibular abnormalities) were used to locate the MF through digital measurements (mm) of the anteroposterior distance from the anterior border of the ramus (MF-AP) and the superoinferior position from the mandibular occlusal plane (MF-SI). Measurements were statistically compared between OPG and CBCT for accuracy. Differences in measurements between OPG and CBCT were compared against the anatomic location (right/left), age and biological sex, assuming a p-value < 0.05 as significant. A total of 204 radiographic records (males: 100/females: 104/mean age: 34.65 ± 11.55 years) were evaluated. The measurements for the MF were MF-AP-OPG (right: 13.53 ± 2.44/left: 13.19 ± 2.25), MF-AP-CBCT (right: 13.61 ± 2.39/left: 13.36 ± 2.19), MF-SI-OPG (right: 5.25 ± 1.71/left: 5.41 ± 1.65) and MF-SI-CBCT (right: 5.59 ± 1.66/left: 5.52 ± 1.61). Measurements between OPG and CBCT were not significantly different, except for MF-SI (right) (p = 0.042). While the overall difference between OPG and CBCT (MF-AP/MF-SI) measurements showed a significant association (p < 0.01) with the anatomic location (right/left), a significant association (p < 0.05) with biological sex was observed only for MF-AP. Based on this study's outcomes, digital OPG is an accurate modality to locate the MF based on anteroposterior (MF-AP) and superoinferior (MF-SI) measurements. This would be clinically beneficial for dental and oral surgeons to achieve the optimum IAN block anesthesia based on preoperative panoramic radiographs. Similarly, it would assist maxillofacial surgeons in planning mandibular orthognathic surgeries and ramus osteotomies without complications.