This paper examines the systemic relationship between triple helix innovation systems and the gross domestic product per capita growth (GDPPC) in terms of sustainable competitiveness in Africa. To do this, the Generalized Moment Method on the panel vector autoregressive model is used to estimate helix models’ (triple helix, quadruple helix, quintuple helix, as well as the open quintuple helix, relative to external contributions) effects on GDPPC between 2007 and 2019 in 27 African countries, and causality tests completion as well. The results show 3 coevolution relationships resulting from the narrow innovation system, which is made up of the burden of government regulations, companies’ expenditures on research and development (R&D) as well as the quality of scientific research institutions. The system expansion (the broad innovation system) with the degree of consumer orientation and natural resource rents generate both 7 (respectively 3 and 4) coevolution relationships. Finally, the opening of the innovation system by considering the business impact of rules on foreign direct investment (BIFDI) alone, generates 5 coevolution relationships. So, in terms of overall sustainable competitiveness strategies in Africa, countries must focus on innovation system opening and natural resources exploitation to increase their GDPPC. Thus, this study fills the gap of a deficit in technological policy orientation on the relationships between innovation systems and sustainable competitiveness through economic growth in Africa.
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