Good governance is an essential component that drives better health outcome and education output required as a catalyst that will stimulate economic growth, and this constitutes a vital social objective as a result of good level of human capital development. The study evaluated the impact of good governance on health outcome among selected African countries using panel data from 2000 to 2020. The Panel unit root tests indicated that real gross domestic product, health outcome, and indicators of good governance are stationary at level while health expenditure and foreign aid are stationary at first difference. The Generalized Method of Moment (GMM) results show that indicators of good governance have positive and statistically significant effects on health outcome in the selected African Countries. Real gross domestic product has a positive and a statistically significant effect on health outcome in the selected African Countries Life expectancy has a positive and statistically significant effect on health outcome in the selected African Countries. Health expenditure has a positive and statistically significant effect on health outcome in the selected countries. Foreign aid has a positive and statistically significant effect on health outcome in the selected African Countries. The study recommends that African Countries should ensure that indicators of good governance such as political stability, accountability and voice, and control of corruption are moving smoothly without any interruption, by so doing economic growth of African countries will increases.