Pandemic Response Research Articles

How norms shape the evolution of prosocial behaviour–compassion, universalizability, reciprocity and equity: a C.U.R.E for social dilemmas

How cooperation evolves and persists widely remains an open problem for improving humanity across domains ranging from climate change to pandemic response. To shed light on how behavioural norms can resolve social dilemmas around cooperation, we present a formal mathematical model of individuals’ decision making under general social norms, encompassing a variety of concerns and motivations an individual may have beyond simply maximizing their own payoff. Using the canonical Prisoner’s dilemma, we compare four norms: compassion, universalizability, reciprocity and equity, to determine which, if any, social forces can facilitate the evolution of cooperation. We analyse our model through a variety of limiting cases, including weak selection, low mutation and large population sizes. This is complemented by computer simulations of population dynamics via a Fisher process, which confirm our theoretical results. We find that the first two norms lead to the emergence of cooperation in a wide range of games, but the latter two cannot. Owing to our framework’s generality, it can be used to investigate many other norms, and how norms themselves evolve. Our work complements recent work on fair-minded learning dynamics and provides a useful bottom-up perspective into understanding the impact of top-down social norms on collective cooperative intelligence.

Strengthening health systems during non-pandemic period: Toward universal health coverage in the pandemic agreement.

Reflecting the experiences of the COVID-19 pandemic, the global response was reviewed by the Independent Review Panel for Pandemic Preparedness and Response. Based on the panel reports, the World Health Organization (WHO) member states decided to establish the intergovernmental negotiating body for drafting a WHO convention, agreement or other international instrument on pandemic prevention, preparedness and response, aiming for approval at the 77th World Health Assembly in 2024 (May 27- June 1). Amidst this process, the National Center for Global Health and Medicine, Japan (NCGM), as a global health organization focusing on health system strengthening in low- and middle-income countries, from the perspective of Universal Health Coverage (UHC), provided technical inputs to the representatives of the Japanese government. This paper summarizes crucial aspects of the NCGM inputs, including maintaining essential health services delivery during a pandemic, responding to evolving demand of health workforce, and ensuring the equitable distribution of pandemic products. These aspects can contribute to not only strengthening health crisis response and preparedness, but also achieving UHC. Therefore, the concerted efforts focusing on UHC and health crisis could yield synergistic effects. In addition, another aspect stresses the importance of social protection systems beyond health sector to reach vulnerable populations experiencing hardships during the COVID-19 pandemic. Since the whole-of-government approach including social policies is covered in the draft pandemic agreement, it is hoped that the upcoming pandemic agreement will trigger each member state to expand the scope of health crisis management beyond the health sector.

Conclusion: Reshaping horizons: the future of events in a post-pandemic world?

PurposeThe purpose of this theme issue is to explore the enduring changes and innovations shaping the future of the event industry in the post-pandemic world. While much of the existing literature focuses on the immediate impacts of COVID-19, this issue aims to provide a comprehensive analysis of the broader transformations, including the integration of sustainability, emerging technologies, and evolving event formats.Design/methodology/approachThe theme issue encompasses a range of methodologies, including systematic reviews, bibliometric analyses, and in-depth case studies. The papers examine various aspects of the event industry, such as the adoption of hybrid event formats, the role of new technologies, and the importance of sustainability in event planning. Each paper contributes unique insights into the future direction of the industry by analyzing trends, technologies, and practices that are defining the next era of event management.FindingsThe findings highlight a significant shift in the event industry towards sustainability, with an increasing emphasis on eco-friendly practices, waste reduction, and the use of sustainable materials. Emerging technologies are also transforming the landscape, enabling more personalized and immersive event experiences. The rise of hybrid and micro-events is identified as a key trend, providing flexibility and inclusivity while maintaining the benefits of in-person interactions. These developments suggest a permanent change in consumer expectations and engagement strategies within the event industry.Originality/valueThis theme issue offers a holistic analysis of the innovative practices, technologies, and trends that are defining the future of the event industry. By bridging the gap between immediate pandemic responses and long-term industry transformations, it provides valuable insights for academics, practitioners, and policymakers looking to navigate the next era of event management.

Older people’s Contributions During the COVID-19 Pandemic Response

ABSTRACT During the COVID-19 pandemic, older people were identified as requiring additional support and protection. This multi-method qualitative study shifts this narrative by asking: how did older people contribute to the COVID-19 public health response? We conducted a reflexive thematic analysis of responses from 870 letter-writers and 44 interviewees who were older people living in Aotearoa, New Zealand during the COVID-19 pandemic. Older people made substantial contributions during the COVID-19 pandemic through: 1) volunteering; 2) nurturing; and 3) advocacy/activism. We argue that policy makers should take seriously the ways older people were providers of help and support in this period.

Severe Acute Respiratory Syndrome and COVID-19 Under the Urban Hierarchy of Municipalities in the State of Rondônia (Western Amazon)

Analyzing the SARS data can provide insights into the severe form of COVID-19, contributing to short, medium, and long-term pandemic response planning. The virus entered Brazilian through air travel, spreading via airport connections. The spatial diffusion of COVID-19 transmission is linked to the territorial division of labor (referring to characteristic daily activities), as reflected in the urban hierarchical network, which serves as a framework for analyzing COVID-19 transmission. This analysis covers mobility aspects such as density, connectivity and the movement of people at different scales. The objective is to evaluate the transmission of SARS and COVID-19 in the state of Rondônia, Western Amazon, between 2020 and 2021, using geoprocessing techniques for spatiotemporal analysis. Maps depicting the urban hierarchy (understood as cities organized by size, from smallest to largest) of the municipalities of Rondônia, along with SARS incidence rates and their standard deviation, were created using QGIS program, version 2.18.20. Spatiotemporal analysis was conducted using Kulldorff statistics to identify clusters of SARS cases in each municipality. A higher concentration of SARS rates ​​was observed in municipalities in the northwestern part of the state. Six spatiotemporal clusters were identified, but no clear pattern of spatial distribution was observed. The spatial diffusion of COVID-19 transmission is linked to the territorial division of labor (i.e., the spatial classification based on the predominant economic activity in each area), as evidenced by the urban hierarchical network, which serves as a reference for analyzing COVID-19 transmission.

Applying up: How ethnographers powered public health changes in the United States during the COVID‐19 pandemic

Abstract“Studying up” was Laura Nader's provocation to anthropologists to scrutinize the actions of the powerful few in relation to the ordeals of the powerless many. Engaging this lineage, this article describes CommuniVax, a rapid ethnographic research coalition supporting an equitable COVID‐19 vaccine rollout in the United States. By tapping hyperlocal knowledge as well as that held by public health and governmental authorities at higher reaches, the coalition opened the possibility for a more just pandemic response and stronger democratic institutions. The project also broke with prevailing features in the studying up tradition: It operated as a multidisciplinary collective rather than a lone ethnographer, partnered with elites rather than a priori holding them at arm's length, and emphasized pragmatic solutions over scholastic critiques. These departures embody an “applying up” modality, supporting the idea ethnographers have plural strategies for studying actors who exert strong influence over others’ lives.

Auto/biography and mobilities in the time of climate emergency

The auto/biographical genre offers theoretical and methodological starting points that are key to a just and ecological mobilities transformation. Just as the COVID-19 pandemic response and its impacts made diverse lifecourse visible, climate change and its contingencies will have similar effects. Simultaneously, digital cultures provide new scope for practising auto/biography and telling about diverse life stories. Through a critical review of the literature and drawing on the new insights of this Special Issue, the paper argues that a research agenda grounded in the auto/biographical is a priority. In contrast to some of the anti-biographical positions that have been influential in mobilities scholarship, the paper argues that: i) the feminist auto/biographical genre accommodates a human subject that is social and historical before being individual, with its performativity being a crucial form for unheard voices to be heard; 2) that it plays a significant role in contesting the frameworks of lifecourse that inform institutional and policy contexts; and, 3) that there is scope for a re-engagement of the non-human and the more-than-human within auto/biographical studies, which though contentious, provides a way to radically re-think how diverse life stories are (im)mobile, and the ways that human and non-human lives are valued.

Measuring the frequency and determinants of COVID-19 prevention behaviours: a cross-sectional assessment of large-scale programmes in seven countries, late 2020

ObjectivesThis multicountry analysis aimed to assess the prevalence of key hygiene prevention behaviours and their determinants, associated with international non-governmental organisation (WaterAid) hygiene behaviour change programmes for COVID-19 prevention. The...

Inhibitors of Rickettsia prowazekii methionine aminopeptidase 1 identified from the Pandemic Response Box

Methionine aminopeptidase (MetAp) enzymes catalyze the post-translational removal of the initiator methionine residue in newly synthesized proteins, a process that is often essential in the maturation of proteins. Consequently, these enzymes serve as important targets for drug development. Rickettsia prowazekii (Rp) is an obligate coccobacillus and the causative agent of the louse-borne epidemic typhus and despite adequate treatment causes a latent infection. This research aimed to identify potential anti-rickettsial agents by screening 400 compounds from the MMV Pandemic Response Box against RpMetAp1. Overall, 19 compounds were identified that possessed IC50 values from 10 µM to 340 nM. The most potent inhibitor was MMV 1580488 (17), which was observed to have an IC50 of 340 nM. The selected hits serve as chemical leads that can be used for the development of potent inhibitors of the RpMetAp1 enzyme.

Discovery of a small-molecule inhibitor of KSHV lytic replication from the MMV pandemic response box

Kaposi's sarcoma-associated herpesvirus (KSHV) is the causative agent for primary effusion lymphoma (PEL), multicentric Castleman's disease (MCD) and Kaposi's sarcoma (KS). KSHV is one of the oncoviruses that contribute to 1.5 million new infection-related cancer cases annually. Currently, there are no targeted therapies for KSHV-associated diseases. Through the development of a medium-throughput phenotype-based ELISA screening platform based on KSHV ORF57 protein detection, we screened the Medicines for Malaria Venture (MMV) Pandemic Response Box for non-cytotoxic inhibitors of KSHV lytic replication. MMV1645152 was identified as a promising inhibitor of KSHV lytic replication, suppressing KSHV immediate-early and late lytic gene expression and blocking the production of infectious KSHV virion particles at non-cytotoxic concentrations in cell line models of KSHV infection with or without EBV coinfection. MMV1645152 is a promising hit compound for the development of future therapeutic agents against KSHV-associated malignancies.

Evolution and impact of COVID-19: A comprehensive overview

This article focuses on COVID-19 during different times, from 2019 to 2024. Which include the background of COVID-19, structures, prevention spread ways and vaccines. Introducing these things about COVID-19 can help people know more about this various, although COVID-19 does not affect humans as much as it used to, and can help people know what got improved during the COVID-19 time, such as the vaccine. By reading this article, people can know more about the details of COVID-19 and can also know more ways to protect themselves. Also, readers can know different kinds of the variant with time goes then appears in the world, and development in the vaccine. This paper explores COVID-19's impact on humanity, the evolution of the virus, and advances in vaccines and treatments, providing insights into the pandemic's progression and response.

Recruitment and retention of pediatric participants for pandemic preparedness research: Experience from the PREMISE EV-D68 Pilot Study

Recruitment and retention are challenges for prospective pediatric cohort studies, particularly those involving serial venipunctures. We investigated factors underlying enrollment and retention in the Pandemic Response Repository through Microbial and Immune Surveillance and Epidemiology (PREMISE) Enterovirus D68 (EV-D68) Pilot Study, a multicenter prospective longitudinal cohort study assessing the utility of immunologic surveillance for pandemic preparedness. This study enrolls children ≤10 years for two blood draws, pre- and post-EV-D68 season, separated by 6–18 months. Overall, 174 children were enrolled in Cohort 1 of the study and 120 (69 %) of children completed the study, with follow-up blood samples obtained from 101 (58 %) of participants. Families were primarily motivated to participate by a desire to help other children, advance science, and better prepare for the next pandemic. Adding research blood draws to clinically indicated blood draws improved enrollment, and multiple study touch points facilitated retention. These findings can be applied to improve recruitment and retention in future pandemic preparedness efforts and longitudinal pediatric cohort studies.

Rapid discovery of monoclonal antibodies by microfluidics-enabled FACS of single pathogen-specific antibody-secreting cells.

Monoclonal antibodies are increasingly used to prevent and treat viral infections and are pivotal in pandemic response efforts. Antibody-secreting cells (ASCs; plasma cells and plasmablasts) are an excellent source of high-affinity antibodies with therapeutic potential. Current methods to study antigen-specific ASCs either have low throughput, require expensive and labor-intensive screening or are technically demanding and therefore not widely accessible. Here we present a straightforward technology for the rapid discovery of monoclonal antibodies from ASCs. Our approach combines microfluidic encapsulation of single cells into an antibody capture hydrogel with antigen bait sorting by conventional flow cytometry. With our technology, we screened millions of mouse and human ASCs and obtained monoclonal antibodies against severe acute respiratory syndrome coronavirus 2 with high affinity (<1 pM) and neutralizing capacity (<100 ng ml-1) in 2 weeks with a high hit rate (>85% of characterized antibodies bound the target). By facilitating access to the underexplored ASC compartment, the approach enables efficient antibody discovery and immunological studies into the generation of protective antibodies.

Identifying Barriers to the Adoption of Digital Contact Tracing Apps in England: Semistructured Interview Study With Professionals Involved in the Pandemic Response.

The NHS (National Health Service) COVID-19 app was a digital contact tracing app (DCTA) used in England in response to the COVID-19 pandemic. The aim of which was to limit the spread of COVID-19 by providing exposure alerts. At the time of the pandemic, questions were raised regarding the effectiveness and cost of the NHS COVID-19 app and whether DCTAs have a role in future pandemics. This study aims to explore key barriers to DCTAs in England during the COVID-19 pandemic. This is a qualitative study using semistructured video interviews conducted with professionals in public health, digital health, clinicians, health care law, and health executives who had an active role in the COVID-19 pandemic. These interviews aimed to explore the perspective of different experts involved in the pandemic response and gauge their opinions on the key barriers to DCTAs in England during the COVID-19 pandemic. The initial use of maximum variation sampling combined with a snowball sampling approach ensured diversity within the cohort of interviewees. Interview transcripts were then analyzed using Braun and Clarke's 6 steps for thematic analysis. Key themes that acted as barriers to DCTAs were revealed by interviewees such as privacy concerns, poor communication, technological accessibility, digital literacy, and incorrect use of the NHS COVID-19 app. Interviewees believed that some of these issues stemmed from poor governmental communication and a lack of transparency regarding how the NHS COVID-19 app worked, resulting in decreased public trust. Moreover, interviewees highlighted that a lack of social support integration within the NHS COVID-19 app and delayed app notification period also contributed to the poor adoption rates. Qualitative findings from interviews highlighted barriers to the NHS COVID-19 app, which can be applied to DCTAs more widely and highlight some important implications for the future use of DCTAS. There was no consensus among interviewees as to whether the NHS COVID-19 app was a success; however, all interviewees provided recommendations for improvements in creating and implementing DCTAs in the future.

Engaging Community Health Workers in the Centers for Disease Control and Prevention's COVID-19 Public Health Response to Address Health Disparities and Build Community Resilience.

In 2021, the Centers for Disease Control and Prevention's (CDC) National Center for Chronic Disease Prevention and Health Promotion (NCCDPHP) funded community health workers (CHWs) for COVID Response and Resilient Communities (CCR). CCR is a 3-year, $350 million initiative to implement CHW strategies aimed at reducing COVID-19 impacts, building resilience, and improving health equity by addressing health-related social needs. This paper describes the CCR initiative and experiences to date, underscoring CHWs' critical role in CDC's pandemic response. CCR funds 67 recipients to reach communities who are disproportionately affected by long-standing health disparities (hereafter, priority populations). CCR aims to decrease the impact of COVID-19 and increase community resilience to respond to COVID-19 and future public health emergencies. Recipients implement three strategies: train CHWs to support the COVID-19 response, increase the workforce of CHWs to manage the spread of the disease, and improve utilization of community and clinical resources to engage CHWs to help strengthen communities' resilience to mitigate the impact of COVID-19. We funded three additional organizations to provide technical assistance to CCR recipients and collaborate with us on a national evaluation of the program. CCR recipients hired about 950 CHWs and integrated these CHWs into over 1,000 organizations and care teams. At the end of the second program year, CHWs made over 250,000 referrals to social services and over 150,000 referrals to address specific health conditions. CCR demonstrates that CHWs can be quickly mobilized to participate in a public health emergency and reach those most affected by COVID-19.

Youth mental health care use during the COVID-19 pandemic in Alberta, Canada: an interrupted time series, population-based study

BackgroundDuring the COVID-19 pandemic, youth had rising mental health needs and changes in service accessibility. Our study investigated changes in use of mental health care services for Canadian youth in Alberta before and during the COVID-19 pandemic. We also investigated how youth utilization patterns differed for subgroups based on social factors (i.e., age, gender, socioeconomic status, and geography) previously associated with health care access.MethodsWe used cross-sectional population-based data from Alberta, Canada to understand youth (15–24 year) mental health care use from 2018/19 to 2021/22. We performed interrupted time series design, segmented regression modeling on type of mental health care use (i.e., general physician, psychiatrist, emergency room, and hospitalization) and diagnosis-related use. We also investigated the characteristics of youth who utilized mental health care services and stratified diagnosis-related use patterns by youth subgroups.ResultsThe proportion of youth using mental health care significantly increased from 15.6% in 2018/19 to 18.8% in 2021/22. Mental health care use showed an immediate drop in April 2020 when the COVID-19 pandemic was declared and public health protections were instituted, followed by a steady rise during the next 2 years. An increase was significant for general physician and psychiatrist visits. Most individual diagnoses included in this study showed significant increasing trends during the pandemic (i.e., anxiety, adjustment, ADHD, schizophrenia, and self-harm), with substance use showing an overall decrease. Mortality rates greatly increased for youth being seen for mental health reasons from 71 per 100,000 youth in 2018/19 to 163 per 100,000 in 2021/22. In addition, there were clear shifts over time in the characteristics of youth using mental health care services. Specifically, there was increased utilization for women/girls compared to men/boys and for youth from wealthier neighborhoods. Increases over time in the utilization of services for self-harm were limited to younger youth (15–16 year).ConclusionsThe study provides evidence of shifts in mental health care use during the COVID-19 pandemic. Findings can be used to plan for ongoing mental health needs of youth, future pandemic responses, and other public health emergencies.

The mediating role of SARS-CoV-2 variants between income and hospitalisation due to COVID-19: A period-based mediation analysis.

The mechanisms facilitating the relationship between low income and COVID-19 severity have not been partitioned in the presence of SARS-CoV-2 variants of concern (VOC). To address this, we used causal mediation analysis to quantify the possible mediating role infection with VOC has on the relationship between neighbourhood income (exposure) and hospitalisation due to COVID-19 among cases (outcome). A population-based cohort of 65,629 individuals residing in British Columbia, Canada, was divided into three periods of VOC co-circulation in the 2021 calendar year whereby each period included co-circulation of an emerging and an established VOC. Each cohort was subjected to g-formula mediation techniques to decompose the relationship between exposure and outcome into total, direct and indirect effects. In the mediation analysis, the total effects indicated that low income was associated with increased odds of hospitalisation across all periods. Further decomposition of the effects revealed that income is directly and indirectly associated with hospitalisation. The resulting indirect effect through VOC accounted for approximately between 6 and 13% of the total effect of income on hospitalisation. This study underscores, conditional on the analysis, the importance of addressing underlying inequities to mitigate the disproportionate impact on historically marginalised communities by adopting an equity lens as central to pandemic preparedness and response from the onset.

COVID-19 and social sustainability: the case of Mauritius

ABSTRACT Social sustainability, alongside environmental and economic sustainability, is one of the three key dimensions of sustainability. Unlike environmental and economic sustainability, social sustainability is often missing from research and practice related to sustainability efforts and policies. Using in-depth qualitative interviews and official document review this article studies the COVID-19 pandemic response of the small island developing state, Mauritius. Using the Opp, Susan M. [2017. “The forgotten pillar: a definition for the measurement of social sustainability in American cities.” Local Environment 22 (3): 286–305] framework for social sustainability, this research finds that Mauritius had both successes and failures in maintaining and promoting social sustainability on the island nation and are at a crossroads with respect to the future of social sustainability on the island. Although the island nation holds an impressive record in engaging in social sustainability efforts, longstanding inequalities were exacerbated during the pandemic and the changed economic outlook may jeopardize the small island's momentum towards their 2030 sustainability goals.

Improving Transparency of Decision Models Through the Application of Decision Analytic Models with Omitted Objects Displayed (DAMWOOD).

The coronavirus disease 2019 (COVID-19) pandemic has increased public awareness of the influence of epidemiological and economic decision models on public policy decisions. Alongside this is an increased scrutiny on the development, analysis, reporting and utilisation of decision models for public policy making. Therefore, it is important that model developers can clearly explain and justify to all stakeholders what is included and excluded from a model developed to support decision-making, to both improve transparency and trust in decision-making. Our aim is to provide tools for improving communication between modellers and decision-makers, leading to improved transparency in decision-making. To do so, we extend the recently described directed acyclic graphs with omitted objects displayed (DAGWOOD) approach from Haber et al. (Ann Epidemiol 68:64-71, 2022) to decision analytic models, giving the decision analytic models with omitted objects displayed (DAMWOOD) approach. DAMWOOD is a framework for the identification of objects omitted from a decision model, as well as for consideration of the effects of omissions on model outcomes. Objects omitted from a decision model are classed as either an exclusion (known and unknown confounders), misdirection (alternative model pathways) or structure (e.g. model type, methods for estimating relationships between objects). DAMWOOD requires model developers to use explicit statements and provide illustration of included and omitted objects, supporting communication with model users and stakeholders, allowing them to provide input and feedback to modellers about which objects to include or omit in a model. In developing DAMWOOD, we considered two challenges we encountered in modelling for pandemic policy response. First, the scope of the decision problem is not always made sufficiently explicit by decision-makers, requiring modellers to intuit which policy options should be considered, and/or which outcomes should be considered in their evaluation. Second, there is rarely sufficient transparency to ensure stakeholders can see what is included in models and why. This limits stakeholders' ability to advocate to decision-makers for the prioritisation of specific outcomes and challenge the model results. To illustrate the application of DAMWOOD, we apply it to a previously published COVID-19 vaccine allocation optimisation model. The DAMWOOD diagrams illustrate the ways in which it is possible to improve the communication of model assumptions. The diagrams make explicit which outcomes are omitted and provide information on the expected impact of the omissions on model results. We discuss the usefulness of DAMWOOD for framing the decision problem, communicating the model structure and results and engaging with those making and affected by the decisions the model is developed to inform.

Evaluation study of the urban governance of the COVID-19 crisis in the city of Antwerp

BackgroundThe COVID-19 pandemic has demanded crisis management at all governance levels. While most research has focused on responses of national governments, city-level governance had significant potential to develop tailored approaches. This study explored how the local COVID-19 response was organised and adapted to the specific city population and context in the City of Antwerp, Belgium.MethodsA case study using semi-structured interviews was set up with 20 key informants with a central role in the coordination and implementation of the city-level COVID-19 response in Antwerp. Thematic analysis of transcripts was guided by an adapted version of the OECD risk management cycle.ResultsRespondents’ accounts provide a granular understanding of pandemic preparedness, crisis management, and response and adaptation to the COVID-19 crisis in a mid-size European city. Its size was large enough to have a strong capacity within its government bodies, to utilise the expertise of strong partners in the area and to mobilise a critical mass for action, yet small enough to quickly establish connections and trust. In addition to a universal approach, they developed tailored responses to specific neighbourhoods and groups. Well-established community and organisational ties enhanced the effectiveness of grassroots initiatives. The perceived feeling of joint action contributed to a strong collective agency, but respondents noted the need for a system for monitoring and learning.ConclusionsLocal governments are important to develop tailored strategies and organise a locally relevant crisis response in cities. They need expertise and agency, with enough flexibility to experiment. To harness promising practices and avoid repeating errors in future crises, it is crucial to develop a system that better evaluates and monitors local responses, before, during and after crises.