Objective: The learning curve of laparoscopic pancreatoduodenectomy (LPD) is long and is associated to high morbidity mainly because of the technical difficulty of the pancreatojejunostomy (PJ). Simulation has demonstrated to shorten the learning curves of advanced laparoscopy. The objective is to present the results of a PJ simulated training programme. Methods: A simulated model using ex-vivo tissue to perform a laparoscopic PJ programme was designed, based on three difficulty levels depending on the Wirsung's duct dilatation (8 mm-5 mm-2 mm). The time, OSATS (5–25 points) and filtration through the anastomosis were registered in each session. Each surgeon must perform a permeable anastomosis in less than 40 minutes, without filtration and OSATS>20 to continue to the next level. Initial and final evaluation of the 2 mm level was performed. Finally surgeons performed the procedure in patients. Results: Two expert surgeons without experience in LPD completed the training programme. During the initial evaluation operatory time was 48/52 minutes, OSATS 14/15 points and both had filtrations in the anastomosis. In the final evaluation operatory time was 25/33 minutes, OSATS 24/23 point, without filtration and good permeability. An average of three sessions was required to complete each level and a total of ten sessions. After the simulated training programme the surgeons performed 7 LPD in real patients. Six patients evolved without complications in the pancreatic anastomosis and only one patient developed a type B fistulae. Conclusion: Simulated training reduces learning curves of the laparoscopic laparoscopic pancreaticojejunostomy. The skills learned in the laboratory are transferred satisfactorily to the operation room.