Objective: Use of Endoscopic Ultra Sound (EUS) and histological and cytological examination of pancreatic lesion can help identifying pancreatic TB and avoid unnecessary surgical procedures. Methods: We retrospectively reviewed the charts of all patients presenting with a pancreatic mass over a period of 3 years (2007–2009). We identified 6 patients with proven diagnosis of TB. The data pertaining to demographic features, sign and symptoms, duration of illness, imaging (X-ray chest, ultrasonography [US], contrast enhanced CT scan , cytology and/or histopathology, and follow up with anti tuberculous therapy (ATT) were obtained. The samples for cytology and/or histology were obtained by US guided aspiration. The histological findings of granuloma with caseation or positive culture were used as the criteria for confirming the diagnosis of TB. Results: * Cases of pancreatic TB were identified, diagnosed and successfully treated. Conclusion: Isolated pancreatic TB can occur especially in endemic areas. In any patient presenting with a pancreatic mass suspicious for carcinoma, EUS and FNA should be performed in order to confirm malignancy and to rule out benign conditions, like TB, that can be treated medically and hence, avoid unnecessary surgical procedures.