Introduction: We report a study of UNOS data over 10 years (2000-9) on the value of HT on the procurement/transplantation (Tx) of organs in 63,593 donors. HT consisted of combinations of thyroid hormone (T3 or T4) +/- anti-diuretic hormone (ADH) +/- corticosteroids (C) +/- insulin (I). Methods: Donors received T3/T4 (49%) or not (51%), but information on other HT, e.g., ADH, C, or I, was lacking in >20,000 cases. In 40,124 donors, all four hormones were recorded; 23,022 (GpA 57%) had received T3/T4 +/- other HT, and 17,102 (GpB 43%) had received other HT, but not T3/T4. Univariate (to evaluate the effect of HT on organ procurement) and multivariate (to determine whether age, gender, race, cause of death, body-mass index, OPO region, or other HT influenced procurement) analyses were carried out. Post-transplant graft/recipient survival was determined at 1 and 12 months. Results: In 63,593 donors, T3/T4 resulted in an overall increased procurement of organs (mean 3.35vs2.97 organs/donor, a 12.8% increase; p<0.0001). The mean number of organs from GpA (3.31) was greater than from GpB (2.87), a 15.3% increase (p<0.0001). Procurement of organs was: Kidney GpA 80.04%, GpB 71.59%, an increase of 8.45% (p<0.0001). Pancreas GpA 21.35%, GpB 15.68%, and increase of 5.67% (p<0.0001). Intestine GpA 2.59%, GpB 2.34% (p<0.05). There was no benefit for the liver. Multivariate analysis indicated benefit to kidney and pancreas procurement independent of other factors (both p<0.0001), but not to liver (p=0.21) or intestine (p=0.56). After kidney Tx there was increased survival of the graft at 1m (p<0.01) and 12m (p<0.001) and of the recipient at 12m (p<0.05). After liver Tx there was increased graft (1m p<0.005/12m p<0.001) and recipient (1m/12m p<0.05) survival. When GpA was compared with GpB, there was reduced survival of pancreas recipients at 12m (p<0.01) but not of grafts. Conclusions:T3/T4 therapy is associated with greater procurement of kidneys, pancreases, and intestines, and improved post-Tx survival kidney and liver grafts and recipients, but with a possible detrimental effect on pancreas recipient survival.