The Tadhak alkaline complexes, located along the eastern edge of the West African craton in northeastern Mali, intrude the 2 Ga old basement or the overlying Pan-African nappes and are covered by Cretaceous sediments. This magmatic activity was accompanied by doming and rifting. Northnortheast trending normal faults define two crustal segments exhibiting variously sized ( <1 km to 17 km) intrusive complexes. These comprise eroded undersaturated ring-complexes with occasional carbonatites in the west and high-level phonolitic plugs with shallow intrusive nepheline syenites in the east. New RbSr isotopic data indicate 100 Ma of within-plate magmatic activity in the area without any obvious age progression. In addition to the Adrar Tadhak complex (262±7 Ma), the following intrusions have been dated: Tirkine (215±11 Ma), Anezrouf (184±14 Ma) and Tidjerazraze-In Imanal (161±5 Ma). A clear break thus exists with the Cambrian alkaline granite province of the Iforas located on the opposite side of the Pan-African suture. 87Sr/ 86Sr initial ratios are similar throughout (between 0.7044 and 0.7049) which indicates a bulk Earth isotopic composition. The conclusion of exclusively mantle origin (“Dupal composition”) previously demonstrated for the Adrar Tadhak complex can now be extended to the other complexes. This implies repeated tapping of a single mantle source throughout the life of the province. The described magmatic and tectonic Permo-Jurassic activity has been triggered by intraplate stresses focussed along the pre-existing Pan-African suture zone. Together with similar features in Europe and Africa, the Permo-Jurassic Tadhak alkaline province heralds the progressive break-up of Pangaea and the opening of the Atlantic Ocean.