The foreland fold and thrust belt of southwest Tarim basin can be divided into four structural zones, and different tectonic sectors have quite different geological conditions related to reservoir-forming. Most favorable locations are Pusha–Keliyang zone and Sugaite–Qimugen zone, not only with many fault-propagation folds, triangle-zone structures, and three sets of excellent source rocks including Lower–Middle Cambrian carbonate, Lower Carboniferous–Lower Permian, and Jurassic dark mudstone but also with a series of good petroleum reservoir and seal combinations such as Lower-Cretaceous sandstone reservoirs associated with Paleogene cap rocks, Paleocene carbonate reservoirs, and Miocene sandstone reservoirs associated with their corresponding mudstone cap rocks, respectively. The second favorable location is Hotan thrust nappe zone with some good tectonic traps including traps of par-autochthonous system and in-situ system, and Lower-Permian mudstone as a set of high quality regional cap rocks, but their source and reservoir are relatively bad, that is, Lower-Permian carbonate source rocks just meet the criteria of gas source rocks, and Lower-Permian sandstone or carbonate reservoirs and Lower-Ordovician carbonate reservoirs are all low-porous and low-permeable in spite of Lower-Permian Pusige mudstone as excellent regional cap rocks. The last, Pamir thrust zone might not be favorable for reservoir-forming due to its large-scale nappes and distinctly-exposed thrust faults which result in the lack of good tectonic traps although there are some advantageous petroleum source-reservoir-seal combinations.