This study was conducted to determine the effect of biodegradation on the nutrient contents of rice bran (RB), cassava residual pulp (CRP), saw dust (SD) and palm oil fibre (POF) by Penicilium sp. RB, CRP, SD and POF were subjected to solid state fermentation by Penicilium sp. for 7 days and the process was terminated by oven drying at 700C for 24hours. The fermented samples were thoroughly mixed, dried and stored in sterile bottles for analyses. Results of proximate composition before and after biodegradation revealed that percentage improvement in crude protein, ether extract, ash, and gross energy were significantly (P<0.05) higher in CRP compared to RB, SD and POF. Similarly, percentage reduction in crude fibre after biodegradation was highest (P><0.05) in CRP compared to other agro industrial wastes products. It was evident that solid state fermentation using Penicillium sp enhanced the crude protein value and reduced the crude fibre contents of rice bran, cassava residual pulp, saw dust and palm oil fibre thereby increasing nutrient availability and their utilization as feed alternative ingredients for farm animal nutrition. ><0.05) higher in CRP compared to RB, SD and POF. Similarly, percentage reduction in crude fibre after biodegradation was highest (P<0.05) in CRP compared to other agro industrial wastes products. It was evident that solid state fermentation using Penicillium sp enhanced the crude protein value and reduced the crude fibre contents of rice bran, cassava residual pulp, saw dust and palm oil fibre thereby increasing nutrient availability and their utilization as feed alternative ingredients for farm animal nutrition.><0.05) n CRP compared to other agro industrial wastes products. It was evident that solid state fermentation using Penicillium sp enhanced the crude protein value and reduced the crude fibre contents of rice bran, cassava residual pulp, saw dust and palm oil fibre thereby increasing nutrient availability and their utilization as feed alternative ingredients for farm animal nutrition.