Quaternary tectonics and paleoseismologicalinvestigations have defined a reliable framework ofactive faults in the southern Umbria and AbruzziApennines. Two sets of NW–SE to NNW–SSE trending, 16to 33 km-long, normal and normal-oblique faults orfault systems have caused the displacement of LatePleistocene–Holocene deposits and landforms within theinvestigated sector. Available data on verticaloffsets indicate that both Late Pleistocene–Holoceneand Quaternary (since the later part of the EarlyPleistocene; 0.9–1 Ma) slip rates range between 0.4and 1.2 mm/yr (range 0.6–0.8 mm/yr preferred).Paleoseismological investigations show that recurrenceintervals for surface faulting events are alwaysgreater than 1,000 years and are usually greater than2,000 years. Both paleoseismological data andlong-term seismicity show that activation of theinvestigated faults may result in earthquakes ofM = 6.5–7.0. The extension rate across the two sets ofprimary faults ranges between 0.7 and 1.6 mm/yr.Horizontal seismic strain has been calculated to be0.5–0.6 mm/yr, based on the summation of the seismicmoment of M > 5.3 earthquakes which have affected theinvestigated area since 1200 AD. This value may belower than that inferred through geological data,probably because the seismological record reliable forthe addition of the seismic moments covers a too shorttime window (about 800 years) to be consideredrepresentative of the tectonic activity in theinvestigated area. This conclusion iscorroborated by the large recurrence intervalper fault (>1,000–2,000 years) inferred frompaleoseismological analysis. A comparison of theactive-fault framework and historical-seismicitydistribution indicates that the entire eastern set ofactive faults has likely not been activated since 1000AD, thus indicating that the elapsed time since thelast activation for several faults of the investigatedarea may be greater than 1,000 years. In terms ofhazard, the highest probability of activation isrelated to the eastern set faults, due to theobservation that the elapsed time for some of thesefaults may be similar to the recurrence interval. Asan example, paleoseismological andarchaeoseismological data indicate that the elapsedtime for the Mt. Vettore and Mt. Morrone Faults may begreater than 1,650 and 1,850 years, respectively.These data may have significant implications for riskrelated to a number of towns in central Italy and tothe city of Rome. As for the latter, in fact,monumental heritage has suffered significant damagedue to earthquakes of M > 6.5 which originated in theinvestigated Apennine sector.