AbstractIngestion of diets containing 50% ground sweet pea seeds (Lathyrus odoratus) by pregnant Sprague‐Dawley rats on days 10‐20 of gestation resulted in high frequencies of fetal resorption and surviving young with various degrees of edema, forelimb flexure, angulation of the vertebral column, micrognathia, cleft palate, and other defects. Pregnant A/J mice maintained on such a diet on days 9‐18 of gestation produced offspring with cleft palate and other malformations. The lathyrus factor, β‐aminopropionitrile (BAPN), given in multiple oral doses to pregnant rats at various times during pregnancy also produced high frequencies of resorption and of young with edema, cleft palate, and malformations of vertebrae and limbs. However, when single doses of 500 mg BAPN were administered on day 15 the resorption rate was markedly reduced whereas the frequency of cleft palate was greatly increased. Three other lathyrogenic agents produced high frequencies of cleft palate in rats: 50 mg aminoacetonitrile on day 15, 400 mg D‐penicillamine on days 10‐15, and 50 mg semicarbazide on days 10‐16. The period of greatest cleft palate susceptibility with all the agents tested was day 15.
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