Actinomycosis is an uncommon infection caused by filamentous Actinomyces, which forms club-shaped filaments arranged in a radiating pattern and rarely infects palate. The clinical presentations are often non-specific, so it posed a challenging situation for clinicians to get diagnosis of actinomycosis. The histopathological study is often helpful for the diagnosis of actinomycosis. The patient needs clinical follow-up for complete healing of the lesion. This case report describes a case of palatal cyst, which was diagnosed as actinomycosis on the basis of histopathological examination. Surgical excision of the cyst with debridement of the granulation tissue is mandatory for such cystic presentation of actinomycosis. This case was undergoing complete excision, followed by amoxycillin and clavulanic administration for 3 months. The bony defect was reconstructed using mucoperiosteal flap of the palate.
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