Extreme low and high precipitation can cause natural disasters (e.g., drought and flood events) which have devastatingeffects on natural environment and the human society. In this study, we present a framework for assessing the stability of spatial dependence of extreme precipitation and their concurrence probability in a nested catchment. The Pearl River basin was used as a case study to test the applicability of the framework. This framework is threefold. This first part involves modeling spatial dependence of both summer maxima and winter minima precipitation between pairs of scattered gauges over the basin by employing the pair-copula constructions as a baseline model. The second part of this framework aims to identify the variability of spatial dependence as a result of the effects of external drivers. Specifically, variations in the spatial dependence of extreme precipitation in the Pearl River basin over different periods associated with the influence of large-scale climate signals were examined. The final part quantifies the probability of occurring extreme precipitation-related events simultaneously over broader areas related to a specific event at a given gauge and the possible spatial extents being affected. The results indicate that the presented framework is able to capture the large-scale spatial dependence structures of both summer maxima and winter minima precipitation. It also allows for explicitly estimating the pairwise concurrence probability of extreme high and low precipitation events and event-impacted areas across the basin.