Dhaleshwari is one of the most important rivers in Bangladesh and plays a vital role in the economy of the Tangail region of Bangladesh due to its geographical position. However, anthropogenic activities are gradually degrading the aquatic system of the river. The present study was conducted at the three selected locations of the Dhaleswari river during March to May 2016 for physicochemical parameters: color, odor, temperature, pH, DO, BOD, EC, TDS; anions: F<sup>-</sup>, Cl<sup>-</sup>, Br<sup>-</sup>, NO<sub>3</sub><sup>-</sup>, NO<sub>2</sub><sup>-</sup>, SO<sub>4</sub><sup>2-</sup> and PO<sub>4</sub><sup>3-</sup> and major heavy metals: Pb, Cd, Cr, Hg and As in order to estimate the current water pollution profile of the river. The color of water were natural to slightly green and odor were unobjectionable. Other measured physicochemical parameters ranged as temperature 29.3-32°C, pH 6.78-8.12, DO 4.11-7.31 mgL<sup>-1</sup>, BOD 0.52-1.74 mgL<sup>-1</sup>, EC 127-487 µScm<sup>-1</sup> and TDS 60-235 mgL<sup>-1</sup>. The anions concentration found as F<sup>-</sup> <0.5, Cl<sup>-</sup> 1.08-6.8, Br<sup>-</sup> <1.0, NO3<sup>-</sup> 0.51-19.7, NO<sub>2</sub><sup>-</sup> <1.0, SO<sub>4</sub><sup>2-</sup> 3.34-9.37 and PO<sub>4</sub><sup>3-</sup> 1.74-4.44 mgL<sup>-1</sup>. The concentration of major heavy metals obtained as Pb <0.01, Cd ˂0.001, Cr ˂0.005, Hg ˂0.001 and As 0.002-0.015 mgL<sup>-1</sup>. The analysis of most of the water quality parameters were performed using standard methods of American Public Health Association. According to statistical analysis, temperature, EC and TDS show positive correlations with each other and negative correlations with pH, DO and BOD which themselves show negative correlations with each other. The anionic pairs Cl<sup>-</sup>-PO<sub>4</sub><sup>3-</sup>, NO<sub>3</sub><sup>-</sup>-SO<sub>4</sub><sup>2-</sup>, and SO<sub>4</sub><sup>2-</sup>-PO<sub>4</sub><sup>3-</sup> show positive correlations and Cl<sup>-</sup>-NO<sub>3</sub><sup>-</sup>, Cl<sup>-</sup>-SO<sub>4</sub><sup>2-</sup> and NO<sub>3</sub><sup>-</sup>-PO<sub>4</sub><sup>3-</sup> show negative correlations with each other. The analysis results of water body in regard to the studied water quality parameters revealed that the quality of water in the selected regions of the Dhaleshwari river is almost suitable for fishing, domestic and irrigation purposes. The water is safe for aquatic biota and human beings and also for industrial use without further treatment. Although adequate measure and treatment should be carried out in the water body for microbial contaminations before using for human consumptions.