Postanesthesia Care Unit Pain Scores Research Articles

Impact of long-acting local anesthesia on clinical and financial outcomes in laparoscopic colorectal surgery

BackgroundOur objective was to assess clinical and financial outcomes with long-acting liposomal bupicavaine (LB) in laparoscopic colorectal surgery. MethodsPatients that received local infiltration with LB were strictly matched to a control group, and compared for postoperative pain, opioid use, length of stay (LOS), hospital costs, and complication, readmission, and reoperation rates. ResultsA total of 70 patients were evaluated in each cohort. Operative times and conversion rates were similar. LB patients had lower post-anesthesia care unit pain scores (P = .001) and used less opioids through postoperative day 3 (day 0 P < .01; day 1 P = .03; day 2 P = .02; day 3 P < .01). Daily pain scores were comparable. LB had shorter LOS (mean 2.96 vs 3.93 days; P = .003) and trended toward lower readmission, complication, and reoperation rates. Total costs/patient were $746 less with LB, a savings of $52,200 across the cohort. ConclusionsUsing local wound infiltration with LB, opioid use, LOS, and costs were improved after laparoscopic colorectal surgery. The additional medication cost was overshadowed by the overall cost benefits. Incorporating LB into a multimodal pain regiment had a benefit on patient outcomes and health care utilization.

Postoperative pain and the use of ultrasound-guided regional analgesia in pediatric supracondylar humerus fractures.

A total of 230 children undergoing closed reduction and percutaneous pinning of supracondylar humerus fractures were analyzed retrospectively. Severe pain (score ≥ 7/10) was reported in 10% of general anesthesia-only patients in the postanesthesia care unit and in 28% of the 130 admitted patients. The 36 patients who received ultrasound-guided regional analgesia+general anesthesia had decreased intraoperative opioid consumption and postanesthesia care unit pain scores. After admission, pain scores and opioid consumption did not differ between fracture and anesthesia types. No patient developed compartment syndrome. Severe pain is frequent after closed reduction and percutaneous pinning of supracondylar humerus fractures. Further study of ultrasound-guided regional analgesia is needed.

Perioperative factors associated with HCAHPS responses of 2,758 surgical patients.

To determine perioperative treatments and events associated with Hospital Consumer Assessment of Healthcare Providers and Systems (HCAHPS) survey responses. Retrospective analysis. Single tertiary care, academic, urban, level-1 trauma center. Final cohort represents 2,758 consecutive surgical inpatients meeting criteria for evaluation by HCAHPS. Responses to four HCAHPS questions were compared against 19 perioperative treatments and events. Positive and negative responses to HCAHPS questions. Patients responding affirmatively with a "9" or "10" to "what number would you use to rate this hospital" were associated with decreased lengths of hospitalization, greater lengths of surgery, decreased intraoperative opioid equianalgesic doses, greater preoperative midazolam doses, shorter post anesthesia care unit (PACU) lengths of stay and decreased last PACU numerical rating scale (NRS) pain scores. Patients responding affirmatively with "yes, definitely" to "would you recommend this hospital to your family" were associated with decreased last PACU NRS pain scores. Patients responding affirmatively with "yes, always" to "How often did the hospital staff do everything to help with your pain" were associated with decreased hospital lengths of stay, decreased chronic benzodiazepine use, greater chronic NSAID use, and decreased PACU lengths of stay. Patients responding affirmatively with "yes, always" to "how often was your pain well controlled" were associated with decreased chronic opioid use, decreased chronic benzodiazepine use, greater chronic NSAID use, increased length of surgery, decreased last PACU NRS pain score, and decreased first PACU NRS pain scores. Subgroup analysis of patients undergoing different types of surgery further characterized factors associated with HCAHPS responses among different surgical populations. These data suggest that demographic factors, preadmission medications, and PACU pain scores but not analgesic medications are associated with patient satisfaction with regards to both pain management and overall satisfaction.

Dose effect of local anesthetics on analgesic outcomes for the transversus abdominis plane (TAP) block in children: a randomized, double-blinded, clinical trial.

Current knowledge on local anesthetic dosage for the TAP block in pediatric patients is very limited. To evaluate the effect of two escalating local anesthetic doses on postsurgical analgesic outcomes in children receiving a TAP block. The study was a prospective, randomized, double-blinded, clinical trial. Children (<8 years) were randomized to one of the two intervention groups: TAP block with bupivacaine at a dose of 2.5 mg · kg(-1) or 1.25 mg · kg(-1). Analgesic outcomes included pain scores in the postanesthesia care unit (PACU), time to analgesic requirement and total number of analgesic requirements. Thirty-six patients were recruited in the study. Pain scores in PACU were not different between study groups. The total number of analgesic dosage required in 24 h after surgery was higher in the lower dose group, median (IQR) of 4 (3 to 5) compared to 2.5 (1.5 to 3) in the greater dose group, P = 0.03. There was a clinically but not statistically significant difference in the time to first analgesic requirement in the 2.5 mg · kg(-1) group, median (IQR) of 248 (130 to 367) minutes compared to 146 (95 to 261) minutes in the 1.25 mg · kg(-1) dose group, P = 0.15. The use of higher local anesthetic doses for the TAP block in children does not provide benefits on early pain scores but seems to improve analgesic duration and decrease the need for additional analgesics over 24 h after surgery. The use of higher, but yet safe, local anesthetic dosages for TAP blocks is a viable strategy to improve analgesia in children.

The association of gender and body mass index with postoperative pain scores when undergoing ankle fracture surgery.

Background:Intraoperative administration of opiates for postoperative analgesia requires a dosing strategy without clear indicators of pain in an anesthetized patient. Preoperative patient characteristics such as body mass index (BMI), gender, age, and other patient characteristics may provide important information regarding opiate requirements.This study intends to determine if there is an association between gender or BMI and the immediate postoperative pain scores after undergoing an open reduction and internal fixation (ORIF) of an ankle fracture with general anesthesia and morphine only analgesia.Materials and Methods:Using a retrospective cohort design, the perioperative records were reviewed at a university healthcare hospital. One hundred and thirty-seven cases met all inclusion and no exclusion criteria. Postanesthesia care unit (PACU) records were reviewed for pain scores at first report and 30 min later as well as PACU opiate requirements. T-test, chi-square, and Mann-Whitney tests compared univariate data and multivariate analysis was performed by linear regression.Results:There were no statistically significant PACU pain score group differences based on gender or BMI. Post hoc analysis revealed that in the setting of similar pain scores, obese patients received a similar weight based intraoperative morphine dose when using adjusted body weight (ABW) compared to nonobese subjects. A further finding revealed a negative correlation between age and pain score (P = 0.001).Conclusion:This study did not find an association between obesity or gender and postoperative pain when receiving morphine only preemptive analgesia. This study does support the use of ABW as a means to calculate morphine dosing for obese patients and that age is associated with lower immediate pain scores.

Of Rough Starts and Smooth Finishes: Correlations Between Post-Anesthesia Care Unit and Postoperative Days 1-5 Pain Scores

The goal of this project was to explore the association between post-anesthesia care unit (PACU) pain scores recorded within the first and second hour of the end of surgery with maximum and median pain scores recorded on postoperative days (PODs) 1 through 5. This study was a retrospective cohort study of clinically documented pain scores in a mixed surgical population. This study was set in a single tertiary-care teaching hospital over a 1-year time period. All patients were adult patients undergoing a single, non-ambulatory, non-obstetric surgical procedure. Pain scores, measured using the numerical rating scale, from PODs 0 through 5 were obtained from an integrated data repository. Kendall's Tau-b correlations were then calculated between maximum pain scores occurring within each of the two PACU time periods and maximum and median pain scores in each of the five ensuing PODs. A total of 349,797 pain scores from 8,332 patients were reviewed. Correlations between maximum pain score by time period demonstrated a significant and high correlation at Tau-b = 0.86, between 1-hour PACU pain scores and 2-hour PACU pain scores. However, the correlation of maximum pain scores recorded in the PACU with those recorded on PODs 1 through 5 was significantly lower, ranging from 0.19 to 0.27. The correlation of maximum PACU pain score with median pain scores recorded on PODs 1 through 5 ranged from 0.22 to 0.29. The correlation structures of the PODs 1 through 5 median pain scores may be consistent with an autoregressive pattern. Maximum scores measured within the PACU likely reflect a set of circumstances distinct from those experienced on PODs 1 through 5.

Comparison of immediate postoperative pain after transvaginal versus traditional laparoscopic cholecystectomy

Transvaginal cholecystectomy (TVC) is the most common natural orifice transluminal surgery (NOTES) performed in women, yet there is a paucity of data on intraoperative and immediate postoperative pain management. Previous studies have demonstrated that NOTES procedures are associated with less postoperative pain and faster recovery times. This study analyzes intraoperative and postoperative opioid use for TVC compared with traditional four-port laparoscopic cholecystectomies (LCs). This is a retrospective analysis of consecutive TVC and LC female patients between August 2009 and August 2012 in an academic institution. We compared demographics, intraoperative and postoperative opioid use and times in the operating room (OR) and in the post anesthesia care unit (PACU). A total of 68 TVC and 67 LC patients were included in this study. The TVC and LC groups were similar in terms of age (both 41 years) and body mass index (29 and 31 kg/m2, respectively). The intraoperative preparation, surgical, and emergence times were significantly longer for the TVC than for the LC (p ≤ 0.01). Compared with the LC group, the intraoperative opioid requirement was significantly greater (TVC 27 mg vs. LC 25 mg; p = 0.003), but after adjusting for anesthesia time, the difference in OR opioid consumption became non-significant (p = 0.08). The PACU opioid requirement (TVC 2.5 vs. LC 5 mg; p = 0.04) was significantly lower for the TVC group, and a greater proportion of patients did not need any pain medications (TVC 38 % vs. LC 21 %; p = 0.04), compared with the LC group. The average PACU pain scores were not significantly different between the groups (p = 0.45). TVC patients did not experience more pain than LC patients. Although the average pain scores of TVC patients did not differ from those of the LC patients, TVC patients did require less pain medication in the PACU.

A Multicenter, Randomized, Controlled Study Evaluating Preventive Etanercept on Postoperative Pain After Inguinal Hernia Repair

Chronic postsurgical pain (CPSP) affects between 5% and 70% of surgical patients, depending on the surgery. There is no reliable treatment for CPSP, which has led to an increased emphasis on prevention. In this study, we sought to determine whether preventive etanercept can decrease the magnitude of postoperative pain and reduce the incidence of CPSP. We performed a multicenter, randomized study in 77 patients comparing subcutaneous etanercept 50 mg administered 90 minutes before inguinal hernia surgery with saline. Patients, surgeons, anesthesiologists, the injecting physician, nursing staff, and evaluators were blinded. The primary outcome measure was a 24-hour numerical rating scale pain score. Secondary outcome measures were postanesthesia care unit pain scores, 24-hour opioid requirements, time to first analgesic, and pain scores recorded at 1 month, 3 months, 6 months, and 12 months. Mean 24-hour pain scores were 3.3 (95% confidence interval [CI], 3.2-4.6) in the etanercept and 3.9 (95% CI, 2.6-4.0) in the control group (P=0.22). The mean number of analgesic pills used in the first 24 hours was 4.0 (SD, 2.8) in the treatment versus 5.8 (SD, 4.2) in the control group (P=0.03). At 1 month, 10 patients (29%) in the treatment group reported pain versus 21 (49%) control patients (P=0.08). The presence of pain at 1 month was significantly associated with pain at 3 months (hazard ratio, 0.74; 99% CI, 0.52-0.97; P=0.03). Although preventive etanercept was superior to saline in reducing postoperative pain on some measures, the effect sizes were small, transient, and not statistically significant. Different dosing regimens in a larger population should be explored in future studies.

Lumbar Plexus Blockade Reduces Pain After Hip Arthroscopy

Hip arthroscopy causes moderate to severe postoperative pain. We hypothesized that performance of a lumbar plexus block (LPB) would reduce postoperative pain in the postanesthesia care unit (PACU) for patients discharged home on the day of surgery. Patients received a combined spinal epidural with IV sedation, ondansetron, and ketorolac. Half of the patients (n = 42) also underwent a single-injection bupivacaine LPB. Postoperative analgesia (PACU and after discharge) was provided with oral hydrocodone/acetaminophen (5/500 mg) and an oral nonsteroidal antiinflammatory drug. IV hydromorphone was given as needed in the PACU. The LPB reduced pain at rest in the PACU (GEE: β estimate of the mean on a 0 to 10 scale = -0.9; 95% confidence interval = -1.7 to -0.1; P = 0.037). Mean PACU pain scores at rest were reduced by the LPB from 4.2 to 3.3 (P = 0.048, 95% confidence interval for difference = 0.007-1.8; uncorrected for multiple values per patient, using independent samples t test for preliminary evaluation comparing pain between the groups). There were no statistically significant differences in PACU analgesic usage, PACU pain with movement, and patient satisfaction. No permanent adverse events occurred, but 2 LPB patients fell in the PACU bathroom, without injury. Three unplanned admissions occurred; one LPB patient was admitted for epidural spread and urinary retention. Two control patients were admitted, one for oxygen desaturation and one for pain and nausea. LPB resulted in statistically significant reductions in PACU resting pain after hip arthroscopy, but the absence of improvement in most secondary outcomes suggests that assessment of risks and benefits of LPB should be individualized.

Impact of intraoperative dexmedetomidine on postoperative analgesia following gynecologic surgery

Objective:To assess the impact of intraoperative dexmedetomidine infusion on postoperative analgesia in women undergoing major open and laparoscopic gynecologic surgery under general anesthesia.Research design and methods:A retrospective analysis of patients who underwent major open and laparoscopic gynecologic surgery under general anesthesia from January 2007 to October 2008. Patients who received intraoperative opioids with a dexmedetomidine infusion were compared to those who received opioids alone. Patients who received regional anesthesia, remifentanil, or other analgesic adjuncts were excluded. Data were collected in the postanesthesia care unit (PACU) for all patients, and for 24 hours in the open group.Results:A total of 580 women were included in the analysis (293 open surgery [103 dexmedetomidine, 190 controls] and 287 laparoscopic surgery [101 dexmedetomidine, 186 controls]). In the open group, patients who received dexmedetomidine required less opioids intraoperatively and in PACU. However, there was no difference in the duration of PACU stay, opioid consumption from PACU discharge to 24 h or in the need for rescue antiemetics. Pain scores were not different in PACU. In the laparoscopic group, there was no difference between the groups in intraoperative or PACU opioids, pain scores, or need for rescue antiemetics. Patients in the dexmedetomidine laparoscopic group needed less inhaled agents intraoperatively, but stayed longer in PACU.Conclusions:Intraoperative dexmedetomidine infusion provided an opioid sparing effect intraoperatively and in PACU in women undergoing open gynecologic surgery but did not reduce the need for rescue antiemetics or the duration of PACU stay and did not provide any benefit beyond PACU discharge. For laparoscopic surgery, dexmedetomidine infusion did not provide any analgesic benefit. Limitations of the study include its retrospective non-randomized nature, absence of strict protocol for dexmedetomidine administration and lack of data beyond PACU discharge in patients having laparoscopic surgery.

Intrathecal Morphine Analgesia in Idiopathic Scoliosis Surgery

We previously determined the intrathecal morphine optimal dose to maximize analgesia in patients undergoing idiopathic scoliosis surgery while minimizing adverse effects. Our purpose was to determine if this protocol was equally effective across sex and racial groups. We studied 287 patients given a moderate dose of intrathecal morphine of 9 to 19 μg/kg (mean 14 μg/kg): 240 female and 47 male patients and 224 White (W) and 63 African-American (AA) patients. Factors analyzed included postoperative visual analog pain scores (VAS), time to first opioid dose, total morphine over the first 48 hours, and postoperative complications of respiratory depression requiring pediatric intensive care unit (PICU) admission, nausea/vomiting and pruritis. For female and male patients, mean VAS pain scores in postanesthesia care unit (PACU) were 0.48 ± 1.14 and 0.56 ± 1.16, mean times to first opioid dose were 16.65 ± 4.38 and 16.72 ± 4.97 hours, and total morphine over the first 48 hours were 1.49 ± 0.53 and 1.49 ± 0.58 mg/kg, respectively. Respiratory depression and PICU admission occurred in 10 of 240 female (4.1%) and 3 of 47 male (6.4%) patients. Minor complications of nausea/vomiting and pruritis occurred in 78 of 240 female (31.7%) and 12 of 47 male (25.5%) patients. For W and AA patients, mean VAS pain scores in PACU were 0.48 ± 1.10 and 0.46 ± 1.13, mean times to first opioid dose were 16.53 ± 3.77 and 17.12 ± 6.05 hours, and total morphine over the first 48 hours were 1.54 ± 0.53 and 1.30 ± 0.53 mg/kg, respectively. Respiratory depression and PICU admission occurred in 9 of 224 W (4.0%) and 4 of 63 AA (6.3%) patients. Nausea/vomiting and pruritis occurred in 77 of 224 W (34.4%) and 11 of 63 AA (17.5%) patients, respectively. Intrathecal morphine results in safe and effective for postoperative pain relief in patients undergoing surgery for idiopathic scoliosis irregardless of sex or race. III, retrospective comparative study.

Role of ketamine and tramadol as adjuncts to bupivacaine 0.5% in paravertebral block for breast surgery: A randomized double-blind study

BackgroundUse of adjuncts to local anesthetics is believed to enhance the quality and duration of the peripheral nerve blocks. We tested the hypothesis that addition of ketamine or tramadol to bupivacaine 0.5% in PVB for patients undergoing modified radical mastectomy would enhance postoperative analgesia.MethodsWe prospectively randomized 60 ASA I–III women into three groups: group B (n = 20) who received PVB using plain bupivacaine 0.5% (control group), group K (n = 21) who received ketamine (0.5 mg kg−1) added to bupivacaine 0.5%, and group T (n = 19) who received tramadol (1.5 mg kg−1) added to bupivacaine 0.5%. All the patients were then given a standardized general anesthesia. Primary outcome was the cumulative fentanyl dose given through patient-controlled analgesia (PCA) device in the first 24 h after surgery. Secondary outcomes included dose of fentanyl in the postanesthesia care unit (PACU), time to first dose of fentanyl, and visual analogue scale (VAS) pain scores in PACU and ward.ResultsThe three groups were found to be similar in the cumulative dose of PCA fentanyl in the first 24 h (P = 0.62). They were also similar in terms of doses of fentanyl used in PACU (P = 0.87), time to first dose of fentanyl requested (P = 0.57), and VAS pain scores at all time points (P > 0.05).ConclusionWe concluded that addition of ketamine (0.5 mg kg−1) or tramadol (1.5 mg kg−1) to bupivacaine 0.5% in PVB for modified radical mastectomy do not have any analgesia-enhancing effect.

Acute and Persistent Postoperative Pain after Breast Surgery

This study's primary aim was to determine levels of acute and persistent postoperative pain and the incidence of severe postoperative pain after mastectomy. A secondary aim was to examine factors associated with postoperative pain. A retrospective cohort study of 196 female breast surgery subjects was conducted. Data were collected on: numerical rating scale (NRS) pain scores in the Post Anesthesia Care Unit (PACU) and at 1 month and 6-12 months postoperative; age; race; insurance; obesity; radiotherapy; chemotherapy; hypertension; anesthesia care time; and intraoperative and PACU opioid use. Severe postoperative pain was defined as NAS > or = 5. Data were analyzed using chi square, Fisher's exact test or analysis of variance, with alpha = 0.05. PACU pain and the incidence of severe PACU pain increased with surgical complexity (P < 0.005). PACU pain scores averaged 4.71 +/- 0.24 and 57.7% of subjects experienced severe pain. Postoperative pain scores at 1 or 6-12 months did not vary by surgical complexity and averaged 2.21 +/- 0.32 and 0.74 +/- 0.22, respectively. Severe postoperative pain was experienced by 22.1% of subjects at 1 month and 8.2% of subjects at 6-12 months. Older age and systolic hypertension were associated with less PACU pain. Non-White race, obesity, and high PACU opioid use were associated with greater postoperative pain at 1 month. Non-White people also had greater postoperative pain at 6-12 months. The results suggest that nearly 60% of breast surgery patients experience severe acute postoperative pain, with severe pain persisting for 6-12 months in almost 10% of patients.

Indwelling interscalene catheter use in an outpatient setting for shoulder surgery: Technique, efficacy, and complications

Indwelling interscalene catheters are utilized for inpatient postoperative pain control after shoulder surgery. Improved medical equipment and advanced techniques may allow safe and efficacious outpatient use. One hundred and forty-four consecutive indwelling interscalene catheter placements were reviewed to determine adverse events, complications, and efficacy. Real-time ultrasound-guided catheter placement technique is described. Post-anesthesia care unit (PACU) narcotic consumption and last recorded pain score were reviewed to gauge efficacy. The catheter placement technique was 98% successful. There were 14 (9.7%) minor adverse events including inadequate analgesia (8), accidental catheter removal (4) of disconnection (1), and shortness of breath (1). The single complication (0.7%) was a small apical pneumothorax. The average PACU narcotic consumption in intravenous morphine equivalents was 1.7 mg. The average last recorded PACU pain score on a scale of 1 to 10 was 0.6. Catheter placement under real-time ultrasound guidance is accurate. Outpatient use of indwelling interscalene catheters is safe and efficacious.

Postoperative Modulation of Central Nervous System Prostaglandin E2by Cyclooxygenase Inhibitors after Vascular Surgery: Retracted

The clinical availability of injectable cyclooxygenase inhibitors allows examination of the importance of cyclooxygenase 1 and 2 after surgery. The authors hypothesize that spinal prostaglandin E2 increases with lower extremity vascular surgery and that spinal prostaglandin E2 decreases with intravenous postsurgical administration of either a mixed cyclooxygenase 1/2 inhibitor (ketorolac) or a cyclooxygenase 2 selective inhibitor (parecoxib). Thirty patients undergoing elective lower extremity revascularization under continuous spinal anesthesia had cerebrospinal fluid obtained at baseline and then up to 6 h after the start of surgery. Four hours after surgical incision, patients were randomized to receive intravenous parecoxib 40 mg, ketorolac 30 mg, or preservative-free normal saline. Patients were administered intravenous fentanyl in the postanesthesia care unit and acetaminophen/oxycodone on the surgical ward to control pain. Cerebrospinal fluid prostaglandin E2 concentrations were increased during and after surgery. After surgery, intravenous parecoxib 40 mg rapidly decreased cerebrospinal fluid prostaglandin E2, and intravenous ketorolac 30 mg also reduced cerebrospinal fluid prostaglandin E2 compared with placebo, but not as much as parecoxib. Postanesthesia care unit pain scores were reduced in the two drug groups compared with placebo, and surgical ward pain scores were also decreased for both drug groups, especially with parecoxib. No patient receiving parecoxib required postoperative intravenous fentanyl. Acetaminophen/oxycodone consumption was reduced in both drug groups compared with placebo, more so with parecoxib. Cerebrospinal fluid prostaglandin E2 is elevated in patients after lower extremity vascular surgery. Postsurgical intravenous administration of the cyclooxygenase 1/2 inhibitor ketorolac, and especially the cyclooxygenase 2 inhibitor parecoxib, reduces cerebrospinal fluid prostaglandin E2 concentration and postoperative pain.