Background: To explore the perioperative effect of the evaluation system of nursing quality in otorhinolaryngology patients. Methods: A total of 100 patients hospitalized in the Department of Otorhinolaryngology of the Third Affiliated Hospital of Qiqihar Medical College, Qiqihar City, China in 2019 were selected as the control group, and routine nursing mode was adopted. The control group was data before the implementation of this study. A total of 100 patients (experimental group) hospitalized in the Department of Otolaryngology in 2020 were selected to adopt the nursing model constructed by nursing quality evaluation system. The adverse mood of patients in the two groups were evaluated at admission and discharge, and postoperative pain and satisfaction were compared between the two groups. Results: Anxiety, depression and quality of life scores were improved in both groups, but the degree of improvement in experimental group was significantly higher than that in control group (t=481.759, 353.502, P<0.05), and the postoperative pain score in experimental group was lower than that in control group (t=54.086, P<0.05). The satisfaction of experimental group was better than that of control group (χ2=30.327, P<0.05). Conclusion: The nursing model based on the evaluation system of the nursing quality of otorhinolaryngology can relieve patients' adverse emotions, relieve postoperative pain of otorhinolaryngology patients, and improve patient satisfaction. Therefore, it is worth popularizing and applying in the future.