Eye Pain Research Articles

Evaluating the Protective Effects of a Dispersive Ophthalmic Viscosurgical Device Versus Balanced Salt Solution on the Cornea During Cataract Surgery.

To compare intraoperative and postoperative effects of applying a viscosurgical device versus balanced salt solution (BSS) during cataract surgery. Single-center retrospective case-control pilot study. Reviewed 27 patients who received Viscoat (Alcon Laboratories, Inc. Fort Worth, TX) or BSS on the cornea during uncomplicated cataract surgery. Surgeries were analyzed for time when the microscope light reflection was indistinct on the cornea while instruments were in the eye. Postoperative data included patient pain ratings, National Eye Institute score, and Ocular Surface Disease Index (OSDI) scores. Compared with BSS, Viscoat application resulted in a significant increase in time with a clear light reflex during surgery (P<0.001). With BSS, average time without a clear light reflex while instruments were in the eye was 82.69±50.14 sec, or 17.56%±12.00% of the surgery, compared with 0% with Viscoat. There was no significant difference in postoperative pain and National Eye Institute score between groups. However, OSDI score two about grittiness was significantly lower with Viscoat application (P=0.01) and approaching significance for OSDI score three, about painful or sore eyes (P=0.09). Viscoat provided greater optical clarity during surgery with a single application and was associated with less sensation of grittiness compared with BSS.

Epidemiology and spatiotemporal analysis of acute hemorrhagic conjunctivitis in Zhejiang province, China (2004–2023)

BackgroundAcute hemorrhagic conjunctivitis (AHC) has become a significant public health issue in Zhejiang province. However, the analysis of epidemiological characteristics and spatio-temporal patterns of AHC in Zhejiang province has not been studied yet.MethodsMonthly cases of AHC from 2004 to 2023 reported at the county level in Zhejiang province were obtained from the China Information System for Disease Control and Prevention. Demographic features, yearly county incidence, global spatial autocorrelation, local spatial autocorrelation analyses, and temporal and space–time cluster analysis were performed to identify and visualize the spatiotemporal patterns of AHC cases in Zhejiang province. The epidemiological characteristics of AHC outbreaks in the same period in Zhejiang province were also compared.ResultsA total of 52,119 AHC cases were reported in Zhejiang province, yielding an average incidence rate of 5.37 per 100,000. No fatalities were reported. The average age of those affected was 25.44 ± 4.37 years, with the highest incidence (16.70%) among individuals aged between 10 and 19 years. Seasonal peaks occur from August to October each year. Students and farmers experienced the highest incidence rates of infection. Significant positive spatial correlations for AHC were observed in Zhejiang province in the years 2007 (Moran’s I = 0.095, p = 0.039), 2009 (Moran’s I = 0.075, p = 0.031), and 2011 (Moran’s I = 0.173, p = 0.034), indicating spatial clustering. Spatiotemporal scanning identified two distinct clusters: Cluster 1 and Cluster 2. Cluster 1, characterized by a relative risk of 21.44 (p &amp;lt; 0.001), was located in northeastern Zhejiang province, comprising 30 counties, with an active period from 1st September 2010 to 30th September 2010. Compared to low-risk regions, high-risk counties exhibited a different demographic profile with a higher proportion of men, older people, and farmers. Among the affected students during outbreaks, the predominant symptoms were conjunctival congestion, increased eye secretions, eye swelling, eye pain, photophobia and tearing, while the incidence of fever was relatively low.ConclusionThe results of this study demonstrate the spatiotemporal heterogeneity of AHC cases in Zhejiang province and underscore the necessity for targeted prevention and control measures in high-risk areas to mitigate transmission and occurrence.

Successful management of drug-resistant rhizobium radiobacter endophthalmitis: A case report.

To report a unique case of post-cataract surgery endophthalmitis caused by Ceftazidime-resistant Rhizobium radiobacter, successfully managed with timely vitrectomy and intravitreal Levofloxacin. A healthy 73-year-old man underwent phacoemulsification and posterior chamber intraocular lens implantation in his left eye. Postoperative ocular examination (OE) one day after the surgery revealed no specific findings. However, on postoperative day 6, he presented with a painful and red left eye. Diagnosed with postoperative endophthalmitis on day 8 at another hospital, he received IVI of Ceftazidime and Vancomycin before being urgently referred to our hospital on the same day. Early vitrectomy and anterior chamber irrigation were performed timely when he arrived on day 8, with cultures identifying Ceftazidime-resistant Rhizobium radiobacter, sensitive to Levofloxacin. Repeated IVI of Levofloxacin (500 mcg/0.1 ml) ensued on post-cataract operative days 13 and 18. Six months post-cataract surgery, the corrected distance visual acuity of the left eye stabilized at 20/33, and OE remained stable. Early vitrectomy and vitreous culture prove effective in managing postoperative endophthalmitis in drug-resistant Rhizobium radiobacter. IVI of Levofloxacin, though rare, proved to be effective in treating Ceftazidime-resistant and Levofloxacin-sensitive pathogens in our case.

Masquerade syndrome secondary to choroidal melanoma in a 73-year-old patient

We present a case of masquerade syndrome secondary to choroidal melanoma, which is a rare presentation of this condition. A 73-year-old patient presented to the emergency department with a history of unilateral red, painful eye, and severe reduction in visual acuity. A Masquerade syndrome was diagnosed after slit lamp examination, and ultrasonography revealed findings suggestive of choroidal melanoma. Metastasis were ruled out, Enucleation was performed, and Histopathological results were consistent with choroidal melanoma without scleral invasion or extraocular extension. This case illustrates an unusual form of presentation for an uncommon pathology, consideration of this syndrome is of utmost importance due to a delayed diagnosis may have significant repercussions on patient mortality.

Anterior Staphyloma (Right eye) with Phthisis bulbi (Left eye): A case report

Background Staphyloma is a clinical condition characterized by an ectasia of the outer coats of the eye with an incarceration of the uveal tissue.[1] Phthisis bulbi is an end-stage clinical condition occurring due to severe eye injury or disease damage which leads to scarring, inflammation, atrophy and finally disorganization of globe and intraocular contents. [3,4] Case presentation A 16 years old boy presented in the OPD with protusion of the eyeball (right eye) and shrunken left eye which is present since birth. He had history of trauma to right eye with stick 5 years back following which he complains of further increase in size of the eyeball to attain the present size. His chief complaint was pain in right eye. SLE showed anterior staphyloma (right eye) along with mild congestion, mild blepharitis and pannus. Perception of light was present in right eye. Left eye findings were suggestive of pthisis bulbi with calcification, narrowing of palpebral aperture. The left eye was sightless, sizeless, shapeless and perception of light is negative in left eye. Conclusion Early identification of ophthalmological problems in infancy &amp; prompt intervention is mandatory for anterior staphyloma. A comprehensive evaluation of the risk factors, control of ocular comorbid conditions, and an early and meticulous surgery can optimize results.

P-2348. Predictors of Dengue Outcome after Adoption of a Management Protocol

Abstract Background Dengue caused a large outbreak in Nepal with over 54,000 reported cases in 2022. Once considered a disease of tropics, dengue has expanded to subtropical and temperate regions of Nepal including Kathmandu valley. A standard protocol, which included screening criteria for admission and treatment based on severity, was adopted at our hospital which is located at the epicenter of 2022 outbreak. Methods We enrolled 261 patients admitted to Patan Academy of Health Sciences between August and October, 2022. We analyzed patients’ baseline clinical and laboratory characteristics as predictors of outcomes including duration of stay and mortality. Results The mean age of the patients was 40.9 (±19.1) years with female predominance (54.4%). Most patients were from Lalitpur district followed by Kathmandu, which are the main catchment areas of the hospital and epicenter of 2022 outbreak. Most common clinical presentations included fever (93.5%),followed by vomiting (65.5%), myalgia (52.1%), headache (45.6%), mucosal bleeding (18.4%), eye pain (16%), anorexia (13.8%), loose stools (13.8%), and rash (10%). The patient’s age correlated directly with both systolic and diastolic blood pressures (p=0.002 and 0.01, respectively), and inversely with platelet counts (p=0.002). Duration of hospital stay (median 3, IQR 2 days) correlated with aspartate aminotransferase (median 141 U/L) and alanine aminotransferase (median 90.5 U/L) levels at presentation (p&amp;lt; 0.001 and p=0.03, respectively). Hemorrhagic rash occurred in 10 patients and was associated with low platelets at day 1 of admission (p=0.01). There were no deaths. Conclusion Elevated aminotransferases as a marker of hepatocellular injury was the main predictor of longer duration of hospital admission. With adoption of a standard screening and treatment protocol, despite varied clinical presentations and complications, no fatalities occurred among the 261 adult patients in our hospital. This underscores the importance of early detection and proper management in effectively combating the disease and preventing mortality. Disclosures All Authors: No reported disclosures

Clinical and Imaging Characteristics of Posterior Scleritis in Children

ABSTRACT Background Posterior scleritis (PS) is a rare phenotype of scleritis. Comprehensive epidemiological studies on PS in children are limited. We aimed to report on its clinical and imaging features in one of the largest pediatric series to date. Methods Retrospective review of medical files. Results Included were 12 children (7 girls, mean±SD age at diagnosis 13.75 ± 3.3 years,18 eyes, mean follow-up ±SD of 46.7 ± 45.9 months). All patients presented with eye pain followed by headache. Papillitis was the most common presenting sign (16 eyes, 88.9%). Seven patients (58%) showed laboratory markers of systemic inflammation. One patient had periodic fever, aphthous stomatitis, pharyngitis, adenitis (PFAPA). In 2 other patients, Behҫet disease and inflammatory bowel disease were diagnosed subsequently. Initial echography showed increased posterior scleral thickness (mean±SD 2.9 ± 0.68 mm) with a significant reduction four ± 2 months later (mean±SD 1.85 ± 0.62 mm). Retinal nerve fiber layer (RNFL) was thickened in all examined eyes (mean±SD 136.2 ± 28.4 µm) at presentation and it significantly decreased with treatment (109.8 ± 8.2 µm two months later). In 5 patients (42%), diagnosing PS was prompted by Brain imaging. PS was part of orbital inflammatory syndrome in 4 patients (33.3%). All patients were treated with systemic steroids and 91% required steroid-sparing agent. Adalimumab was added in 2 patients. A chronic course was observed in 63.6%. Remission was achieved in 4 patients. Mean±SD presenting LogMAR VA was 0.23 ± 0.3 with marked improvement to 0.04 ± 0.07 one month later. Conclusion Searching for an associated autoinflammatory/autoimmune disease is an important step in patients’ triaging. B-scan ultrasound remains the gold standard test. OCT proved to be of practical importance in delineating the magnitude of RNFL thickness and could serve as a potential imaging biomarker of disease activity.

Case Report on Tolosa Hunt Syndrome in a Diabetic Patient: An Uncommon Presentation

Tolosa Hunt syndrome (THS), also known as painful ophthalmoplegia, recurrent ophthalmoplegia, or ophthalmoplegia syndrome, is described as severe and unilateral periorbital headaches associated with painful and restricted eye movements. THS is one of the rare disorders recognized by the National Organization for Rare Disorders. The estimated annual incidence is one case per million per year. Case Report: A 49-year-old male with a 12-year history of Type 2 Diabetes Mellitus presented with diplopia, ptosis, and right-sided hemifacial pain. Neurological examination revealed right-sided levator palpebrae superioris palsy, complete ophthalmoplegia, and conjunctival hyperemia. MRI confirmed orbital apex syndrome (OAS) in the right orbit known as Tolosa hunt syndrome (THS), while paranasal sinus HRCT showed chronic sinusitis with significant mucosal thickening and structural abnormalities. Management included high-dose intravenous methylprednisolone with gastroprotective therapy, followed by a tapering course of oral prednisolone and gabapentin for neuropathic pain. Keywords: Tolosa Hunt Syndrome (THS), Orbital Apex Syndrome (OAS), Methylprednisolone, Ophthalmoplegia

Simultaneous Four-site Restoration of Bilateral Scleromalacia Using Autologous Tragal Perichondrium and Preserved Sclera

Purpose: We report a case of bilateral nasal and temporal four-site scleromalacia following cosmetic conjunctivectomy, successfully managed with simultaneous restoration surgery at all four sites using autologous tragal perichondrium and preserved scleral graft.Case summary: A 56-year-old woman who underwent cosmetic conjunctivectomy on both eyes 15 years earlier, presented with intermittent eye pain. Examination revealed scleromalacia with calcium plaques in all four nasal and temporal scleral areas. The most extensive avascular area was in the nasal region of the right eye, and the most prominent uveal exposure was in the nasal area of the left eye. Considering the lesion and exposure sizes of the avascular zone and uvea exposure, preserved sclera was transplanted to the temporal and nasal areas of the right eye, while autologous tragal perichondrium was transplanted to the nasal area of the left eye. Tenon's capsule vessels were fixed with pedicle flaps in all four surgical areas for vascularization. Frozen amniotic membrane was transplanted in the nasal area of the left eye, where the conjunctival defect was substantial, and in the lateral area of the left eye, where no graft was used. The conjunctival epithelium was closed using autologous conjunctival flaps in all four areas. Post-surgery, successful engraftment and vascularization of the graft materials were observed in both eyes.Conclusions: Even with multiple areas of scleromalacia in both eyes, successful results can be achieved during simultaneous surgery if an appropriate graft material is selected and the surgery is performed utilizing principles of tissue restoration.

Clinical features, treatment, and prognosis of zoledronic acid-induced uveitis.

Uveitis is a rare ocular adverse reaction of zoledronic acid, the specific clinical features are not clarified. This study was to investigate the clinical features of zoledronic acid-induced uveitis and provide reference for rational use of zoledronic acid. We collected clinical data on zoledronic acid-induced uveitis for retrospective analysis by searching Chinese and English data up to October 31, 2024. Uveitis occurred in 44 patients with a median age of 66.5 years (range 47, 87) and 93.2% in females. The median time to onset of uveitis was 48 h (range 10, 192). Eye pain (86.4%), decreased vision (61.4%), and redness (50.0%) were the most commonly described symptoms. Uveitis could involve unilateral eyes (68.2%) and bilateral eyes (31.8%), and anterior uveitis was the main type (95.5%). Most patients had intraocular pressure within the normal range. Slit lamp examination mainly revealed cells (54.5%), flare (43.2%), and keratic precipitates (29.5%). After discontinuation of zoledronic acid (97.6%) and receipt of topical steroids (97.7%), systemic steroids (15.9%), and cycloplegics (72.7%), all patients showed improvement or recovery. Zoledronic acid-induced uveitis mainly occurs within 72 h after the initial administration, and anterior uveitis is predominant. When zoledronic acid is used, patients should be informed of possible adverse eye reactions. Topical corticosteroids can be used as the main treatment for uveitis.

Characteristics of ocular findings of patients with coronavirus disease 2019 in China.

This study aimed to report the ocular manifestations in individuals with coronavirus disease 2019 (COVID-19) and investigate any correlation between the occurrence of ocular symptoms and systemic symptoms. A retrospective electronic survey was conducted among the general public in northern China from December 2022 through February 2023. Inclusion criteria for COVID-19 was confirmed testing positive via a polymerase chain reaction (PCR) test or testing positive for COVID-19 via an antigen kit. The anonymous survey collected information on demographics, systemic COVID-19 symptoms, ocular diagnosis and symptoms, comorbidities and disease history. A total of 2,405 survey responses were collected and the final analysis included individuals in the 335 COVID-19 positive group and 434 individuals in the COVID-19 negative group. Among COVID-19 positive patients 66.3% (n = 222) reported experiencing ocular symptoms. Dryness (n = 106, 31.6%), blurred vision (n = 81, 24.2%), eye pain (n = 72, 21.5%), and itching (n = 71, 21.2%) were the main features. COVID-19 was found to be associated with a higher prevalence of conjunctivitis, iritis, uveitis, retinal vein occlusion and optic neuritis. The majority of individuals (51.0%) developed eye symptoms after the onset of COVID-19 systemic symptoms. There was no significant association between the severity of systemic symptoms and ocular symptoms. Individuals with COVID-19 were significantly more likely to experience ocular symptoms. COVID-19 was found to be associated with a higher prevalence of retinal diseases. The majority of individuals developed ocular symptoms right after the onset of systemic symptoms.

Man with vision loss and eye pain

Man with vision loss and eye pain

Fronto-Orbital Osteoblastoma With Unilateral Exophthalmos: A Rare Presentation and Review of Diagnostic Challenges.

Osteoblastoma is an uncommon benign bone tumor rarely involving the craniofacial skeleton. Manifestations in the fronto-orbital region are exceptionally rare. A 19-year-old man presented with persistent headache, nausea, vomiting, right eye pain, and longstanding right exophthalmos. Imaging revealed a heterogeneous enhancing lesion located in the right anterior cranial fossa-orbital apex junction causing pressure on the orbital roof. Differential diagnoses included fibrous dysplasia and meningioma. The tumor was resected via frontal craniotomy. Definitive diagnosis of osteoblastoma was achieved postoperatively through histopathological examination and IHC studies. Craniofacial osteoblastomas, especially in the fronto-orbital region, are exceptionally rare and may present radiological features similar to other bone pathologies. Accurate diagnosis hinges on histopathological evaluation. A multidisciplinary approach is pivotal for successful diagnosis and treatment of such challenging cases.

Retained lens fragment causing anterior uveitis four years after successful phacoemulsification

Introduction: Existing literature has detailed occurrences of retained cataract lens fragments identified days to weeks after cataract surgery. However, lens fragments in the anterior chamber remaining asymptomatic for several years are extremely rare, thus remaining a diagnostic challenge. A complex case of a retained lens fragment causing anterior uveitis 4 years after phacoemulsification is presented. Patient and Clinical Findings: A 76-year-old woman presented with a chief concern of right eye pain, photosensitivity, and blurred vision after head trauma. Diagnosis, Intervention, and Outcomes: Diagnostic imaging ruled out the presence of orbital fracture or globe deformity leading to an initial diagnosis of traumatic iritis. Initial management with topical corticosteroids did not improve symptoms. Subsequent slit lamp examination revealed a small cataract lens fragment in the anterior chamber leading to a diagnosis of anterior uveitis secondary to the retained lens. Anterior chamber washout was performed with successful removal of the fragment, and the patient reported resolution of pain and photosensitivity postoperatively. Conclusions: Owing to its rarity, diagnostic and treatment standards for retained cataract lens fragments have not yet been sufficiently explored. This case suggests that head trauma may be a precipitating event causing delayed onset of symptoms. Cataract lens retention should be considered in patients presenting with uveitis years after cataract surgery.

Evaluation of Older People's Presentations to the Emergency Department With Pain During and Before the COVID-19 Pandemic.

This study aimed to determine the tendency of older adults to present to the emergency department with pain complaints during the COVID-19 pandemic compared to the prepandemic period. A cross-sectional, retrospective study design was used. Data were collected from the electronic medical records of older people who presented to emergency departments with pain before (March 2019-March 2020) and during the COVID-19 pandemic (April 2020-July 2021). We identified 10 pain diagnosis groups using ICD-10 codes. Patient data were grouped and cleaned using SQL scripts on the Oracle database. It was determined that 13.3% of 405,404 older people had presented to the emergency department with pain between March 2019 and July 2021. There was a 14.2% decrease in such admissions during the pandemic period. In the study, an increase was observed in the rates of older adults presenting to the emergency department with myalgia and joint pain. In contrast, the rates of those presenting with low back and neck pain, headache, eye pain, dysuria, and acute pain decreased during the pandemic. In the regression analysis, predictors for older adults' presentation to the emergency department with pain included age over 85 years (OR: 1.403), female gender (OR: 1.053), and myalgia (OR: 2.471). During the COVID-19 pandemic, our study revealed fewer presentations to the emergency department for pain-related complaints. To prevent severe health problems from delayed care, we recommend expanding telemedicine, remote pain management, and home-based care. Further research is needed to examine the long-term effects of increased myalgia and joint pain.

Management of a case of stromal herpetic keratitis

Aims/Purpose: To present a case study of stromal herpetic keratitis (SHK) and emphasize the importance of accurate differential diagnosis and appropriate therapeutic approaches in primary care settings.Methods: A detailed anamnesis and ocular examination were conducted, including fluorescein staining to identify dendritic corneal ulcers indicative of herpetic keratitis (HK). The patient was followed closely with a combination of antiviral and corticosteroid therapy.Results: A 20‐year‐old woman presented with 72 hours of left eye redness, pain, tearing, and vision loss. No traumatic history was reported, but a recent herpetic lesion on the upper lip was noted. Clinical examination revealed significant conjunctival hyperemia and a characteristic dendritic lesion on the cornea. Detailed examination with a slit lamp showed a central dendritic ulcer stained with fluorescein and peripheral infected cells stained with rose Bengal, alongside a focal stromal inflammation. These findings confirmed the diagnosis of SHK. Follow‐up revealed resolution of the stromal inflammation and closure of the dendritic epithelial defect.Conclusions: The case underscores the critical need for accurate diagnosis of HK subtypes, as SHK requires specific treatment with topical corticosteroids in addition to antiviral therapy. Clinical guidelines indicate that the benefits of corticosteroid use in SHK outweigh the risks, though close monitoring is essential to mitigate adverse effects such as increased intraocular pressure and cataract formation. This case highlights the importance of prompt specialist referral when primary care practitioners encounter complex ocular presentations, ensuring timely and appropriate management to prevent irreversible vision loss.References Guidelines for Ocular Herpes Management. SECOIR Monography: Update on Corneal Infections. Chapters 7 and 11.

Ocular bee sting with retained stinger

Aims/Purpose: Ocular bee stings are a rare but can lead to severe inflammatory complications. Some cases have been described, but stinger retention is exceptional. We report the case of a young patient with a limbal bee sting, with stinger retention.Methods: A male 19‐year‐old, presented a painful red eye following an accidental bee sting. Examination found a visual acuity of 20/20, conjunctival hyperaemia, a clear cornea, calm anterior chamber, and a perilimbal foreign body, which corresponded to the bee stinger.We performed a conjunctival peritomy and removed the stinger using McPherson forceps under topical anesthesia. The sclera being intact, we sutured the conjunctiva and prescribed antibiotiotics and steroid drops. Evolution was marked with improvement and disappearance of symptoms.Results: Bee sting wounds can penetrate tissues like a harpoon, complicating the stinger's removal, along with possible sequelae: mechanical like corneal abrasion or intrastromal retention, and toxic effects. The venom contains phospholipase A2 and mellitin, leading to membrane lysis and pain, as well as apamin, which causes mast cells degranulation and histamine release. It can cause conjunctivitis, corneal infiltrates, cataract, uveitis, hyphema, lens subluxation, retinal lesions, optic neuropathy or choroidal detachment.Conclusions: Ocular bee stings are rare and can induce severe inflammation. Extraction of the stinger and topical antibiotic associated with steroids are the treatment of choice, in addition to close monitoring of possible complications.References Gudiseva H, Uddaraju M, Pradhan S, Das M, Mascarenhas J, Srinivasan M, Prajna NV. Ocular manifestations of isolated corneal bee sting injury, management strategies, and clinical outcomes. Indian J Ophthalmol. 2018 Feb; 66(2): 262‐268. Chilibeck, C., Wang, N., &amp; Murphy, C. (2021). Making a bee‐line for the eye: a limbal sting and retained honey bee. Clinical and Experimental Optometry, 104(4), 538–540.

Drug-induced myopia mimicking angle closure glaucoma – A diagnostic dilemma

A 17-year-old female patient presented with complaints of acute onset of headache with bilateral eye pain since 1 day, associated with H/O blurring of vision in both eyes. No H/O redness or watering of eyes, ocular trauma. Patient has H/O migraine for which she was on Sumatriptan. No H/O of any chronic illness or chronic medication. No H/O of any previous spectacle use or ocular treatment. The visual acuity in both eyes was recorded 5/60 with improvement with pinhole to 6/18. Subjective correction showed myopia of -4 D in right eye and -3D in left eye. The IOP measurement was 58 mm Hg in both eyes. Gonioscopy showed closed angles in both eyes. Ocular alignments were orthophoric and extraocular movements were free and full in all directions of gaze. Anterior segment examination of both eyes showed shallow anterior chamber. Undilated examination of fundus of both eyes was normal. Sumatriptan was stopped and patient was started on topical anti glaucoma drug and aqueous suppressant. Within a week of commencement of treatment, patient improved symptomatically with complete resolution of myopia with vision in both eye 6/6 and IOP becoming normal with deepening of anterior chamber.

Reducing disconfort in contact lens wearers: Refitting symptomatic users to Kalifilcon A

Aims/Purpose: The prevalence of discomfort associated with contact lens (CL) wear is estimated to affect up to half of the wearers, often resulting in the discontinuation of CL wear. This study aimed to determine whether refitting symptomatic wearers with a daily disposable CL (Kalifilcon A) reduces symptoms and improves the wearer experience.Methods: 47 symptomatic CL wearers (CLDEQ‐8 &gt; 12) were randomly assigned in a masked fashion to receive either Kalifilcon A or their usual CL (placebo). Following one month of CL wear, participants were switched to Kalifilcon A or placebo, which they wore for another month. Non‐invasive tear break‐up time measurements were performed using a Medmont E300USB topographer. Furthermore, the participants completed the CLDEQ‐8 and NEI VQF‐25 questionnaires to assess symptomatology and vision‐related quality of life while wearing CLs. Finally, the participants were asked to subjectively rate the ease of handling, manipulation and comfort of both CLs.Results: After a one‐month period of wearing both CLs, the results of theCLDEQ‐8 revealed a statistically and clinically significant reduction in symptomatology with Kalifilcon A CL (10.95 ± 8.82) in comparison to the placebo CL (14.65 ± 7.83; p = 0.02). The NEI VFQ‐25 questionnaire outcomes indicate that Kalifilcon A CL exhibits a substantial improvement in the subscales of eye pain, with a score of 59.4 ± 9.9, compared to the score of 47.3 ± 8.2 (p &lt; 0.0001), and in the subscales of role difficulties, with a score of 10.1 ± 13.9, compared to the score of 38.6 ± 8.2 (p &lt; 0.0001).In terms of subjective rate, Kalifilcon A CL demonstrated superior performance in terms of overall satisfaction with comfort (7.78 ± 1.88vs8.5 ± 1.86; p = 0.01) and overall satisfaction with the CL (7.8 ± 1.89vs8.44 ± 1.61; p = 0.04). The results of the tear quality study revealed no statistically significant differences between the two CLs.Conclusions: Refitting individuals who exhibit symptoms while wearing CLs with Kalifilcon A daily disposable contact lenses resulted in a significant reduction in the incidence of symptoms and a noticeable enhancement in the user's overall experience. This presents a valuable solution for those who may otherwise be at risk of discontinuing CL wear.

Ocular Symptoms Among COVID-19 Positive Patients in Saudi Arabia: A Cross-Sectional Survey.

Background Coronavirus disease (COVID-19), a widespread viral illness, has been linked to a range of respiratory and other systemic symptoms. Along with the respiratory symptoms caused by severe acute respiratory syndrome coronavirus (SARS-CoV-2), many extrapulmonary manifestations have also been reported. This study was conducted to report the ocular manifestations of COVID-19 in confirmed cases from the Qassim region, of Saudi Arabia. Methods In this retrospective survey-based study, anelectronic survey was distributedviasocial media toindividualswho reported a positiveCOVID-19test. Demographic data,medical and ocular history,anddata about their COVID-19 infection and ocular symptoms were collected. Results Atotal of 200 survey responses were included (35% male and 65% female,age30.3 years).At least one ocular symptom was reported by41(20.5%)participants.Light sensitivity(8.5%),blurredvision(7.5%),redness(7.0%),and eye pain(7.0%) werethe mostcommon ocular symptoms. Conclusion Among the study participants, ocular symptoms were reported by more than one-fifth of the COVID-19 patients. These ocular symptoms were mostly mild. Further research is required to fully understand the association between COVID-19 and ocular manifestations.