Heat management poses severe constraints when designing non-adiabatic multi-tubular packed-bed reactors for strongly exothermic or endothermic catalytic processes. The exploitation of conduction in the solid matrix of engineered continuous internals (e.g., honeycomb monoliths, open-cell foams, periodic open-cell structures) as a heat transfer mechanism alternative, or possibly additional, to fluid-phase convection, is a promising strategy to relax some of these constraints, offering new opportunities for the intensification of catalytic reactors. Preliminary experimental data and modelling studies show that this is particularly true for compact-scale applications, when conductive internals are packed with catalyst micro-pellets. In this work, through pilot-scale testing, we show that overall heat transfer coefficients as high as 1300 W/m2/K can be achieved in periodic open-cell structures (POCS) made of a highly conductive aluminium alloy, 3D printed with an external continuous skin and packed with 300–400 μm catalyst micro-pellets. To this aim, a Fischer-Tropsch experimental campaign has been carried out in a pilot-scale rig, using an established 20 wt% Co/Al2O3 catalyst formulation and a tubular reactor (28.80 mm I.D., 20 cm catalyst bed length) externally cooled with an isothermal diathermic oil. Thanks to the outstanding heat transfer properties of the packed-POCS reactor, by progressively increasing the oil temperature from 180 °C to 225 °C, once-through CO conversions as high as 70 % have been measured at gas hourly space velocities exceeding 4000 cm3(STP)/h/gcat, resulting in C5+ yields in excess of 0.35 g/h/gcat, with a CH4 selectivity always below 15 %. Such performances, made possible by the intensified heat management granted by the adopted reactor internals, are among the best ever reported for a compact-scale Fischer-Tropsch tubular reactor.