Medicine Packaging Research Articles

Norms of Translating Medical Terms in English Patient Information Leaflets into Kurdish

Patient Information Leaflets (PILs) are documents included in medicine packages and provide important information about the medication for patients. This study investigates the translation problems of English PILs into Sorani Kurdish. The aim of this study is to identify the translation procedures used for translating medical terminologies in PILs for lay people. It also aims to reveal which translational norms are operating in Kurdish translations of PILs. To do so, the study employs a corpus of 150 English PILs along with their Kurdish translations. To analyse the corpus, the researcher adopts Toury’s (1995-2012) three-phase methodology within the descriptive approach of translation. It also uses Vinay and Darbelnet’s (1995) translation procedures to determine how translators handled terminological rendering in the Kurdish PILs. According to the findings, nine types of translation procedures were used in translating the terminologies, with borrowing had the highest frequency, and modulation having the lowest frequency. They also revealed that Toury’s initial norms were predominantly operating in the translated PILs which labelled them as adequate translations. The translators’ choice to closely follow the original PILs was indicative of their attempt to meet the expectations of PILs’s target users, thus, revealing Chesterman’s expectancy norms therein. The study concludes that the translation of PILs into Kurdish is not regulated within the medical field and that is mainly related to the absence of an officially regulated body in the Kurdistan Region of Iraq. It also concludes that while the seemingly established norm of PIL translation into Kurdish highly relies on English borrowings, it is a significant step towards developing Kurdish medical language.

Analysis of MDA, SOD, TAOC, MNCV, SNCV, and TSS scores in patients with diabetes peripheral neuropathy.

To explore the impact of score in patients with diabetes peripheral neuropathy (DPN) treated with traditional Chinese medicine package (TCMP) plus red light therapy and lipoic acid on malondialdehyde (MDA), erythrocyte superoxide dismutase (SOD), total antioxidant capacity (TAOC), motor nerve conduction velocity (MNCV), sensory nerve conduction velocity (SNCV), and Toronto Clinical Scoring System (TSS). A total of 108 patients with DPN hospitalized in the hospital were chosen and divided into groups with the random number table. In the control group (CG) 54 patients were treated with conventional lipoic acid, and 54 patients in the experimental group (EG) accepted TCMP plus red light on the basis of the CG. The MDA, SOD, TAOC, MNCV, SNCV, and TSS scores before treatment and after treatment were compared between the two groups. Before treatment, there was no statistically significant difference in the levels of oxidation indicators, nerve conduction velocity, and symptom scores between the two groups (P > 0.05). After treatment, the MDA in the EG was lower than that in the CG, with a statistical significance difference (P < 0.05). The SOD and TAOC in the EG were higher than those in the CG, and the difference was statistically significant (P < 0.05). The MNCV and SNCV of median nerve, common peroneal nerve, and tibial nerve in the EG were significantly higher than those in the CG (P < 0.05). The TSS score of the EG was lower than that of the CG, and the difference was statistically significant (P < 0.05). The treatment of patients with DPN with lipoic acid plus TCMP and red light therapy can improve the symptoms and signs of disease, promote the recovery of motor and sensory conduction velocity, and optimize the body oxidation indicators.

Carbon footprint of oral medicines using hybrid life cycle assessment

BackgroundHealthcare represents 3–8% of a country's carbon footprint, and medicines are estimated to represent 20–55% of healthcare's carbon footprint. Unfortunately, only scarce and partial medicine life cycle assessments (LCAs) are reported due to the limited availability of needed data to perform them. MethodsWe describe a method to estimate the cradle-to-pharmacy gate LCA of all oral medicines from the French pharmacopeia (n = 12,316 medicines) that includes the entire medicine-related carbon footprint, encompassing active pharmaceutical ingredient (API), excipients and packaging production, transport, medicine manufacturing, and associated corporate emissions using a hybrid LCA/environmentally extended input-output model. The uncertainty surrounding this estimation is modeled using bootstrap. FindingsAlthough the API carbon footprint is correlated with synthesis yield, its number of steps, presence of chiral center(s), and process mass intensity, the API carbon footprint is better predicted by its wholesale cost. Corporate emissions (34.5%), API production (28.5%), and medicine manufacturing (25.5%) are the most impactful contributors to medicine carbon footprints, while medicine packaging (5.3%), transport (3.6%), and excipients (2.7%) are less significant. Variations from one medicine to another are substantial. The mean carbon footprint of a medicine box is 8.47 kgCO2eq/box (median 1.46 kgCO2eq, 95% CI 0.34–73.98). Medicines' carbon footprint is correlated with their price but not linearly, as low-cost medicines have significantly higher emission factors of 0.2–0.3 kgCO2/€ versus 0.05–0.1 kgCO2/€ for high-cost drugs. Orphan and innovative medicines tend to have higher carbon footprints. InterpretationMedicine carbon footprints are highly variable. This database allows for a better understanding of the carbon footprint associated with medicines, in order to better eco-design care pathways.

Mechanical and optical properties assessment of an innovative PDMS/beeswax composite for a wide range of applications

Polydimethylsiloxane (PDMS) is an elastomer that has received primary attention from researchers due to its excellent physical, chemical, and thermal properties, together with biocompatibility and high flexibility properties. Another material that has been receiving attention is beeswax because it is a natural raw material, extremely ductile, and biodegradable, with peculiar hydrophobic properties. These materials are applied in hydrophobic coatings, clear films for foods, and films with controllable transparency. However, there is no study with a wide range of mechanical, optical, and wettability tests, and with various proportions of beeswax reported to date. Thus, we report an experimental study of these properties of pure PDMS with the addition of beeswax and manufactured in a multifunctional vacuum chamber. In this study, we report in a tensile test a 37% increase in deformation of a sample containing 1% beeswax (BW1%) when compared to pure PDMS (BW0%). The Shore A hardness test revealed a 27% increase in the BW8% sample compared to BW0%. In the optical test, the samples were subjected to a temperature of 80 °C and the BW1% sample increased 30% in transmittance when compared to room temperature making it as transparent as BW0% in the visible region. The thermogravimetric analysis showed thermal stability of the BW8% composite up to a temperature of 200 °C. The dynamic mechanical analysis test revealed a 100% increase in the storage modulus of the BW8% composite. Finally, in the wettability test, the composite BW8% presented a contact angle with water of 145°. As a result of this wide range of tests, it is possible to increase the hydrophobic properties of PDMS with beeswax and the composite has great potential for application in smart devices, food and medicines packaging films, and films with controllable transparency, water-repellent surfaces, and anti-corrosive coatings.

Sustainable valorization of waste plastic into nanostructured materials for environmental, energy, catalytic and biomedical applications: A review

The extensive production and utilization of plastic products are inevitable in the current scenario. However, the non-degradable nature of waste plastic generated after use poses a grave concern. Comprehensive efforts are being made to find viable technological solutions to manage the escalating challenge of waste plastic. This review focuses on the progress made in transformation of waste plastic into value-added nanomaterials. An overview is provided of the waste plastic issue on a global level and its ecological impacts. Currently established methodologies for waste plastic management are examined, along with their limitations. Subsequently, state-of-the-art techniques for converting waste plastic into nanostructured materials are presented, with a critical evaluation of their distinct merits and demerits. Several demonstrated technologies and case studies are discussed regarding the utilization of these nanomaterials in diverse applications, including environmental remediation, energy production and storage, catalytic processes, sensors, drug delivery, bioimaging, regenerative medicine and advanced packaging materials. Moreover, challenges and prospects in the commercial level production of waste plastic-derived nanomaterials and their adoption for industrial and practical usage are highlighted. Overall, this work underscores the potential of transforming waste plastic into nanostructured materials for multifaceted applications. The valorization approach presented here offers an integration of waste plastic management and sustainable nanotechnology. The development of such technologies should pave the way toward a circular economy and the attainment of sustainable development goals.

Potential medicine waste in the process of outpatients receiving cost-free medicines from medicine pick-up lockers in the North Denmark region

ObjectivesIn the Danish healthcare system, restructuring is an ongoing process to accommodate the rising number of patients and to optimise resource allocation. To ease departmental burdens at hospitals in the...

Prevalence of Medications Errors and Factors of Harmful Errors in Neonates and Paediatrics at Tertiary and Paediatric Hospitals: A Multicenter Study

Medication errors (ME) are human mistakes that may occur during drug use, prescribing administration or monitoring. This study aimed to determine the Prevalence of MEs among pediatric patients receiving tertiary treatment in pediatric speciality hospitals and describe their patterns and causes. Three institutions participated in a multicenter retrospective analysis. Reports of all MEs involving paediatrics aged ≤13 years who were hospitalised or visited the Emergency Department or outpatient clinics were reviewed 1 January 2019 - 31 December 2019. The National Coordinating Council for Medication Error Reporting and Prevention classification was used to categorise MEs and to define PRME (category CI) and patient–harming MEs (category EI). A retrospective study was conducted with a total of 318 MEs reported, with an overall prevalence of 0.9 per 1,000 patients. The Prevalence was markedly lower in the CHT (0.35 / 1,000 patients) than in KAMC and KFSH&amp;RC (1.73 and 3.5). The highest rate of MEs was observed in admitted wards (14.69 / 1,000 patients). Most commonly, MEs occurred at the prescribing stage (81.1%), were caused by a physician (83.3%), and were discovered by the pharmacist (85.5%). Improper medication dosage (34.0%), frequency (14.2%), and duration (10.4%) were the three most common forms of MEs. Paediatric inpatient treatment has a significant frequency of MEs, accounting for 24% of hospitalisations. The ME may not get to the patient if independent double-check prescriptions, accurate medication reconciliation of new prescriptions against the previously prescribed, and improved medicine labelling and packaging techniques are used.

Lack of braille labelling and instructions on Chinese pharmaceutical packaging

Braille labels and instructions on medicine packaging are scarce in China, impeding blind individuals’ ability to obtain information about medications. Article 37 of China’s Barrier-Free Environment Creation Law, enacted in September 2023, requires braille labelling and instructions for pharmaceuticals. This provision offers essential legal protection to ensure the safety of blind individuals when using medications. Nevertheless, the use of braille labels and instructions for medicines is hindered by ambiguous statutes, limited social consciousness, financial factors and technological constraints. To promote the use of braille on medicinal labels and instructions, China should bolster its legislation, increase social consciousness, alleviate the financial strain on pharmaceutical manufacturers, foster technological advancement and encourage collaboration and self-governance within the pharmaceutical industry.

Medicine Package Recommendation via Dual-Level Interaction Aware Heterogeneous Graph

Medicine Package Recommendation via Dual-Level Interaction Aware Heterogeneous Graph

Study of color degradation in package prints: Analyzing kinetics with principal component analysis

AbstractColor degradation is a pressing issue in various fields like food and medicine packaging, as well as printed materials, leading to a loss or distortion of vital information. Therefore, understanding how the color of package prints evolves over time is essential for product quality assessment and effective product life cycle management. This study focuses on investigating color changes in prints on blister foils, widely used in the medicine and packaging industries. To assess fading characteristics, samples printed via the gravure process have been exposed to a Xenon Test Chamber (B‐SUN). Spectrophotometric measurements of the prints have been conducted using a spectroradiometer, and the data have been analyzed using principal component analysis (PCA). The fading nature of cyan and black prints aligns with Type IV, while magenta and yellow prints correspond to Type II, as described by Giles. Notably, cyan and black inks demonstrated resistance toward fading at the end of the exposure, with a minor exception. The investigation involved curve fitting, revealing a consistent first‐order kinetic model governing fading rates throughout the exposure time. High R2 values (0.96–0.99) and low root means square error values (0.02–0.08) are observed across all cases. While color fading involves diverse kinetics, the fading rate consistently adheres to a singular first‐order kinetic path. The study highlights that yellow ink is most sensitive to light, followed by magenta ink. These findings offer valuable insights for optimizing packaging materials and ensuring product quality in industries reliant on printed materials. By mitigating color degradation, manufacturers can enhance the longevity and appeal of their products, reinforcing consumer trust and satisfaction. Furthermore, the effective utilization of PCA as a data analysis tool offers a valuable approach for future investigations in color science and related fields.

Nominalization in Arabic translations of patient information leaflets

Patient information leaflets (PILs) inserted in medicine packages constitute a genre written by experts for an audience of laymen, but studies of PILs in Arabic report low readability. According to the lay friendliness framework developed by Jensen (2013) for translated PILs, nominalization is one of the linguistic factors that contribute to PILs’ low readability. Although nominalization has been extensively studied in scientific texts including medical papers, no studies examine its use and effect on lay friendliness in PILs translated into Arabic. This study analyzes a parallel corpus of English PILs and their Arabic translations to examine the frequency and forms of nominalization introduced into the Arabic translations. Considering Givon’s (1993) definition of nominalization, all instances of finite verb phrases in the Source Texts (ST) that are fully or partially nominalized in the Target Texts (TT) were examined. Examples are discussed in terms of the level and function of nominalization in the target language.

Outer packaging labelling of medicines in Southern African Development Community (SADC) countries: comparative analysis of requirements and transition terms for harmonisation

IntroductionThe COVID-19 pandemic highlighted an urgent need for harmonised requirements for the regulation of medicines. To fully implement harmonised medicines regulations across Africa, common technical standards of medicine regulations are needed. One such technical standard is the labelling of medicines on outer packaging. In this study, we compared outer packaging labelling requirements and transition terms for harmonization for countries in the Southern African Development Community (SADC) region.MethodsData on legislation and/or regulatory guidelines for medicine outer packaging labelling from National Medicines Regulatory Authorities (NMRAs) were obtained for countries in the SADC region (n = 16) by February 2023. A detailed comparative content analysis was conducted to determine alignment with the requirements of the Southern African Development Community (SADC) harmonised labelling guidelines to assess readiness levels of each country to transition to the SADC harmonised labelling guideline for outer packaging of medicines.ResultsContent analysis showed at least 11 out of 16 countries require national legal reform to transition to the SADC harmonised labelling guideline. In all cases where countries specified labelling requirements for outer packaging of medicines, these were stipulated in national medicines legislation.ConclusionEven though there is a high level of alignment across the countries in terms of national labelling requirements, most countries in the SADC region would still require national legislative reform to transition to regional harmonised labelling requirements and then ultimately to continental requirements of the African Medicines Agency (AMA).

The mode of herbal medicine preparations and packaging: Selected plants for management of diseases in Sunyani Municipal, Ghana

The mode of herbal medicine preparations and packaging: Selected plants for management of diseases in Sunyani Municipal, Ghana

Evaluation of knowledge, attitude, and perception of pictograms in improving understanding of foreign medicine packages and leaflets among Malaysians

Access to foreign medicines is now more prevalent due to globalization and international travel. However, understanding the labels and content of these medications can be challenging due to the language barrier. Pictograms are visual representations of words or phrases, that can be used on foreign medicinal packages and leaflets to ensure the correct usage of the medications. This study aims to explore the knowledge, attitude, and perception of pictograms in improving the understanding of foreign medicine packages and leaflets among the Malaysian population. Methods: This was a cross- sectional study with stratified random convenience sampling. A total of 397 Malaysian respondents participated in this study. A set of questionnaires was distributed using the Google Forms platform. The scores on knowledge, attitude, and perception were assessed based on previous studies by Bloom’s cut- off point criteria. SPSS version 28.0 was used to analyze the data.

New Advance Innovative Packaging of Medicines

New Advance Innovative Packaging of Medicines

Translating Two Respiratory Chinese Patent Medicine Package Inserts Based on Western Orientation of Theory and Methodology

Translating Two Respiratory Chinese Patent Medicine Package Inserts Based on Western Orientation of Theory and Methodology

Traditional Chinese Medicine packaging therapy and nursing of a patient with phlebitis caused by peripheral intravenous infusion of anti-tumor Traditional Chinese Medicine

Traditional Chinese Medicine packaging therapy and nursing of a patient with phlebitis caused by peripheral intravenous infusion of anti-tumor Traditional Chinese Medicine

Supporting the Influence of Psychological Capital and Transformational Leadership on Organizational Citizenship Behavior

This action research aims to find out whether psychological capital and transformational leadership affect organizational citizenship behavior through work engagement with employees of a pharmaceutical packaging-based company in Bekasi. The data collection method in this study used survey methods and distributed questionnaires, respondents were selected by purposive sampling method. the criteria were permanent employees who worked in the same company based on the packaging of medicines located in Bekasi and have worked for at least the last 1 year. The number of samples used was 218 people. The analytical method used is the analysis structural equation model (SEM). The findings from this study were psychological capital, transformational leadership's positive and significant effect on work engagement, and work engagement's positive and considerable influence on organizational citizenship behavior. But psychological capital and transformational leadership does not affect organizational citizenship behavior. Besides that, psychological capital and transformational leadership have positive and significant effects on organizational citizenship behavior through work engagement. In addition, the results found that work engagement can mediate the influence between psychological capital and transformational leadership on organizational citizenship behavior.

Ghana's herbal medicine industry: prospects, challenges and ways forward from a developing country perspective.

The herbal medicine industry is one of the fastest growing industries in the world. However, no detailed assessments have been undertaken on how to achieve the benefits of this industry for developing countries. This study examined the herbal medicine industry in Ghana, with a particular focus on its prospects, challenges and ways forward. The prospects of the medicinal plant trade are huge, and include reducing the national health budget, being a source of foreign and domestic income, as well as creation of employment and poverty reduction. However, the industry is currently inundated with several challenges, such as registration of herbal medicine products and practitioners, a lack of clinical trials for herbal products, standards and quality control issues, shortage of raw plant materials for production, and insufficient scientific research to support traditional claims on the pharmacological effects of medicinal plants. I propose a number of interventions to address these challenges: increased government support, capacity building initiatives, improved regulation of herbal medicines, application of modern technology in the manufacturing of herbal products, large-scale cultivation of medicinal plants, and improved packaging and branding for herbal medicines. Both the national government and the private sector have crucial roles to deliver in the development of the herbal medicine industry in a country like Ghana.

Experience of the adequacy and appropriateness of pharmaceuticals-related environmental information and preferred information channels among Finns

The normal use of medicines is the major environmental source of pharmaceuticals and a significant contributor to the chemicalization of the environment. Despite the key role of medicine users in contributing to this environmental challenge, little research has been conducted into the current state of lay people's pharmaceuticals-related environmental information, namely the information received, the information needed, the topics included in the information received, topics of interest, and previous and preferred information channels. In this study, these aspects were studied among 2,030 Finnish adults by means of an electronic survey. Of the respondents, 84.5% had received information related to pharmaceuticals in the environment (PiE). Female gender, higher age, high education level, general environmental friendliness, and use of prescription medicines were associated with a greater likelihood that information had been received. Furthermore, 39.8% of the respondents considered the amount of information received to be sufficient. Respondents had most commonly received information on 1 to 3 different topics. Proper disposal of medicines and pharmaceutical residues ending up in the environment in general were the most common topics covered by the information received. Medicines disposal and the effects of environmental pharmaceutical residues on people were the most interesting topics among the respondents. PiE-related information was most commonly obtained from traditional media (80.4%) and websites (40.5%), the least common source of PiE-related information being physicians (1.6%). The respondents were eager to receive such information in the future, preferring traditional media and medicine package leaflets as the most convenient information channels. These findings indicate a need for more diverse PiE-related information via easily accessible information channels that can vary based on sociodemographic characteristics.