The goal of this study is evaluate whether a healthy foods initiative (HFI) at a major national US food retailer (Walmart) improved the nutrient profile of packaged food and beverage purchases (PFPs). We used a longitudinal, commercial dataset of US household PFPs from Walmart and other chain retailers (OCR) to compare trends in the overall nutrient density and percent volume of key food group in the post-HFI period (2011-2013) to expected trajectories of nutrient profiles based on the pre-HFI (2000-2010) trends (n= 164,315). We controlled for concurrent changes in the social, economic, and food retail environment, and used inverse probability weights to account for potential selectivity of customers into Walmart and OCR stores. While Walmart PFPs showed major declines in energy, sodium, and sugar density from 2000 to 2013, as well as declines in the percent volume of sugary beverages, grain-based desserts, snacks, and candy, these declines were steepest between 2000 to 2007 before the HFI. For most nutrient densities and food groups, and across all race and income subgroups, post-HFI declines were similar to what would be expected based on pre-HFI trends, indicating that the HFI did not have a major impact. Nutrient densities of PFPs from OCR showed only minor declines across the time period. While the nutrient profile of Walmart PFPs improved over time, these trends were already well underway by the time the HFI was initiated, suggesting that the HFI itself did not improve nutrient profile or reducing diet disparities. This work is supported by the Robert Wood Johnson Foundation (Grant 67506, 68793,70017,71837), NIH (R01DK098072) and the Carolina Population Center (R24 HD050924, T32 HD007168).