Clay mineral assemblages have been investigated in a sequence of Late Quaternary age sediments (160 ka) from the Santa Barbara Basin off California. These predominantly terrigenous sediments contain an assemblage of clay minerals dominated by smectite mostly derived from discharges of the Santa Clara River, together with illite and kaolinite from adjacent relief. Besides its characteristic clay mineral signature, the Santa Clara River has the largest drainage basin in this region and contributes most of the terrigenous load to the Santa Barbara Basin. Smectite contents of the sediments in the basin may therefore be used as a proxy for precipitation and run-off. Distinct changes in the relative abundance of smectite allow reconstruction of the pattern of precipitation, and its relations with regional environments and global climate. This showed that major intervals of precipitation coincide with local development of pine during glacials, and oak during terminations and interglacials; some expansion of mountain glaciers in the Sierra Nevada, especially when they occur during local minima of insolation; and lacustrine developments in the now arid continental interior of California. Major precipitation intervals started during glacials, and persisted during terminations and early interglacials, associated with a weak California Current and subsequent expansion of warm Pacific surface waters. In detail, major precipitation intervals consist of alternating episodes of higher and lower rainfall modulated by orbital precession, with a significant correlation between episodes of high rainfall and minima in precession, which were times of increased meridional gradients, enhanced poleward heat transfer and northward expansion of tropical waters.