Objective To investigate the effects of eyes-closed (EC) and eyes-open (EO) EEG field powers on the auditory P300 evoke potentials.Methods The EEG was recorded in 12 healthy male college students (20 ~24 years) respectively in their eyes-closed and eyes-open states,and then the auditory P300 paradigm was performed.Results ① Alpha band was distributed at the posterior-occipital area,while Alpha-1 (7.5~9.5 Hz) field power were EC as (2.62 ±0.81 ) μV2 and EO as ( 1.80 ±0.56) μV2,with statistical significance (P < 0.01 ) ; Alpha-2 ( 10 ~ 12 Hz) field power were EC as ( 8.55 ± 1.85 ) μV2 and EO as (4.95 ± 1.59 )μV2,also with statistical significance (P<0.05).②In P300,the Common stimulus elicited clear component N1 (90ms)and P2 (180ms) in the ERPs after stimulus,while there were no significant differences between EC and EO states.Correspondingly,the rare stimulus elicited clear component N2 (207 ms) and P3 (313 ms) in the ERPs after stimulus on-set.Comparing the differences of field potentials of the rare stimulus between the two states,N2field potential in EC ( (0.01 ± 0.71 ) μV) was smaller than that in EO ( ( - 2.13 ± 0.80 ) μV ),with statistical significance (P < 0.05 ) ; while P3 field potential in the EC ( ( 4.16 ± 1.08 ) μV ) was smaller than that in EO ( (4.78 ± 1.20) μV),but without statistical significance (P > 0.05 ).Conclusion The alpha field power is higher in eyes-closed than in eyes-open state,while performing the same auditory P300 paradigm,significant reduction of field potential in the N2 component are observed in eyes-closed than in eyes-open state. Key words: Eyes-closed,Eyes-open,EEG DMN; ERPs,P300,Field power; Field potential