We study the stability of p-wave superfluidity against quantum fluctuations in two-dimensional Fermi gases near a p-wave Feshbach resonance . An analysis is carried out in the limit when the interchannel coupling is strong. By investigating the effective potential for the pairing field via the standard loop expansion, we show that a homogeneous p-wave pairing state becomes unstable when two-loop quantum fluctuations are taken into account. This is in contrast to the previously predicted $p + ip$ supefluid in the weak-coupling limit [V. Gurarie et al., Phys. Rev. Lett. 94, 230403 (2005)]. It implies a possible onset of instability at certain intermediate interchannel coupling strength. Alternatively, the instability can also be driven by lowering the particle density. We also discuss the validity of our analysis.