Summary Distributed Acoustic Sensing (DAS) technology enables the detection of waves generated by seismic events, generally as uniaxial strain/strain rate time series observed for dense, subsequent, portions of a Fiber Optic Cable (FOC). Despite the advantages in measurement density, data quality is often affected by uniaxial signal polarization, site effects and cable coupling, beyond the physical energy decay with distance. To better understand the relative importance of these factors for data inversion, we attempt a first modeling of noise patterns affecting DAS arrival times for a set of seismic events. The focus is on assessing the impact of noise statistics, together with the geometry of the problem, on epicentral location uncertainties. For this goal, we consider 15 ”real-world” cases of DAS arrays with different geometry, each associated with a seismic event of known location. We compute synthetic P-wave arrival times and contaminate them with four statistical distributions of the noise. We also estimate P-wave arrival times on real waveforms using a standard seismological picker. Eventually, these five datasets are inverted using a Markov chain Monte Carlo (McMC) method, which offers the evaluation of the relative event location differences in terms of Posterior Probability Density (PPD). Results highlight how cable geometry influences the shape, extent, and directionality of the PPDs. However, synthetic tests demonstrate how noise assumptions on arrival times often have important effects on location uncertainties. Moreover, for half of the analyzed case studies, the observed and synthetic locations are more similar when considering noise sources that are independent of the geometrical characteristics of the arrays. Thus, the results indicate that axial polarization, site conditions, and cable coupling, beyond other intrinsic features (e.g., optical noise), are likely responsible for the complex distribution of DAS arrival times. Overall, the noise sensitivity of DAS suggests caution when applying geometry-only-based approaches for the a priori evaluation of novel monitoring systems.