You have accessJournal of UrologyKidney Cancer: Localized IV1 Apr 2014MP59-17 CLINICAL SIGNIFICANCE OF POSITIVE SURGICAL MARGIN ON ONCOLOGIC OUTCOME AFTER PARTIAL NEPHRECTOMY IN PATIENT WITH RENAL CELL CARCINOMA Myong Kim, Kyoungrok Kim, Woo Suk Choi, Minsoo Choo, Young Ju Lee, Hyeon Jeong, Chang Wook Jeong, Kwan Jin Park, Ja Hyeon Ku, Cheol Kwak, and Hyeon Hoe Kim Myong KimMyong Kim More articles by this author , Kyoungrok KimKyoungrok Kim More articles by this author , Woo Suk ChoiWoo Suk Choi More articles by this author , Minsoo ChooMinsoo Choo More articles by this author , Young Ju LeeYoung Ju Lee More articles by this author , Hyeon JeongHyeon Jeong More articles by this author , Chang Wook JeongChang Wook Jeong More articles by this author , Kwan Jin ParkKwan Jin Park More articles by this author , Ja Hyeon KuJa Hyeon Ku More articles by this author , Cheol KwakCheol Kwak More articles by this author , and Hyeon Hoe KimHyeon Hoe Kim More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2014.02.1813AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail Introduction and Objectives There has been the consensus to ensure adequate surgical margin in partial nephrectomy. However, the range of safety margin has not been established. In recent years, it is reported that the preservation of renal function, as well as tumor control is an important factor effect on survival. Moreover, in the new laparoscopic and robot-assisted partial nephrectomy era, we have become more interested in the correlation of margin status and oncologic outcome, however the large-scale, long-term results regarding this issue have not been reported. Methods From January 1991 to June 2012 with 785 patients with solitary renal cell carcinoma who underwent partial nephrectomy were retrospectively analyzed. The correlation of pathologic T stage, surgical margin status, length of safety margin and disease free survival (DFS) and cancer specific survival (CSS) were analyzed. Results Mean follow-up period was 39.2 (±28.3, SD) months. Out of 785 patients, 675 (86.0%) were with T1a tumors, 78 (9.9%) with T1b, 3 (0.4%) with T2 and 29 (3.7%) with T3, respectively. Of 785 patients, 9 (1.1%) were tumor positive on surgical margin. The mean length of safety margin was 3.1 (±2.8) mm. During follow-up period, recurrences were occurred in 36 (4.6%) patients, of which 15 (1.9%) cases with local recurrence, 21 (2.7%) patients had a distant recurrence. In the same period, 8 (1.0%) cases of cancer specific mortality occurred. In Kaplan-Meier survival analysis, 10-year DFS rate was 78.9%, and 10-year CSS rate was 95.5%. Cox proportional hazard analysis showed the positive surgical margin was not significant factor for DFS (p=0.545) or CSS (p=0.824). In 9 positive surgical margin patients (mean follow-up period of 47 months), one patient (11.1%, 55 months after the surgery) had a local recurrence and no cancer specific death had occurred. When the length of safety margin were divided by the cut point of 1mm, 2mm, 3mm, 4mm and 5mm, Cox proportional hazard analysis could not confirmed the significant cutoff point (p-value range: 0.100-0.965). Conclusions Our data show that the surgical margin status and the length of safety margin do not affect oncologic outcome. © 2014FiguresReferencesRelatedDetails Volume 191Issue 4SApril 2014Page: e656-e657 Advertisement Copyright & Permissions© 2014MetricsAuthor Information Myong Kim More articles by this author Kyoungrok Kim More articles by this author Woo Suk Choi More articles by this author Minsoo Choo More articles by this author Young Ju Lee More articles by this author Hyeon Jeong More articles by this author Chang Wook Jeong More articles by this author Kwan Jin Park More articles by this author Ja Hyeon Ku More articles by this author Cheol Kwak More articles by this author Hyeon Hoe Kim More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...