Anisaldehyde Research Articles

Immobilized aldehydes and olefins in the solid support synthesis of tetrahydroquinolines via a three component condensation

Two novel and highly efficient solid support (SS) versions of tetrahydroquinoline synthesis based on the three component condensation reaction of aldehydes, anilines, and electron-rich olefins catalyzed by trifluoroacetic acid were described. In the first version, 4-carboxybenzaldehyde was immobilized on Acid sensitive MEthoxy Benz Aldehyde ( AMEBA) resin as the solid-supported component of this reaction. The procedure provided tetrahydroquinolines in high yield (60–80%) and good purity (>80%). Further advancement of this solid-phase synthesis was achieved by using resin-bound olefins (prepared from immobilized 4-hydroxybenzaldehyde, and the corresponding Wittig reagents) with anilines, and aldehydes to afford the target products (61–85% yields, >85% purity). Both SS approaches allowed the use of novel alkene, aniline, and aldehyde entries, thereby yielding a diverse array of tetrahydroquinolines.

Production of 2-hydroxy 4-methoxy benzaldehyde using root cultures of Hemidesmus indicus

Nodal explants of Hemidesmus indicus plants cultured in half strength Murashige and Skoog medium fortified with 2 mg indole-3-butyric acid l−1 in the dark produced 10–12 roots (1–2 cm) with minimal callusing in 10 days. Roots, ∼20 mg dry wt, cultured in Gamborg et al. medium supplemented with 2 mg IBA l−1, sucrose (4% w/v), pH (5.6) and agitation (70 rpm) in the dark yielded 550 mg root dry wt/flask and 0.18% 2-hydroxy 4-methoxy benzaldehyde in the roots after 30 days. The maintenance of normal morphology of the roots, consistent biomass and product yields over a 21-month period indicated the stability of the cultures. © Rapid Science Ltd. 1998

Antifertility Activity and Toxicity of a-Chlorohydrin Aromatic Ketal Analogues in Male Rats

The antifertility activity and toxicity of alpha-chlorohydrin and seven aromatic ketal derivatives were investigated in male rats. At a dose of 5 mg/kg injected intraperitoneally each day for 14 days, alpha-chlorohydrin and the methoxy benzaldehyde derivative (compound 2) produced complete infertility. The benzaldehyde derivative (compound 1) was 89% effective and the other five compounds 71-25% effective. All compounds except the least effective antifertility agent, the methylbenzaldehyde derivative (compound 3), reduced the motility of sperm recovered from the epididymis. None of the compounds caused a decrease in body or testes weight but some increased adrenal weight.

Isolation and Identification of Anisaldehyde and Three Alkaloids From Leaves of Thalictrum minus var. microphyllum

Isolation and Identification of Anisaldehyde and Three Alkaloids From Leaves of Thalictrum minus var. microphyllum

Preparation of 2‐isoxazolines from C(α),O‐dilithiooximes and aldehydes and ketones

AbstractC(α),O‐Dilithiooximes were condensed with aldehydes and ketones to give β‐hydroxyoximes which were usually isolated and characterized. These materials could be acid‐cyclized to give the 2‐isoxazoline. When the dianion was condensed with p‐anisaldehyde, it was not necessary to isolate the intermediate; direct acid‐cyclization after condensation led to the 2‐isoxazoline.

Kinetics of the cross cannizzaro reaction of anisic aldehyde with formaldehyde in aqueous solutions of KOH

1. The kinetics of the Cannizzaro reaction of anisic aldehyde with formaldehyde in aqueous solutions of KOH with concentrations from 5.22 to 40.8% at 25 ±0.1° was investigated spectrophotometrically. 2. The reaction proceeds by two parallel pathways, while the reactive complexes are formed from twice ionized forms of formaldehyde and a nonionized molecule of anisic aldehyde with the participation of the K+ cation and without it. 3. From the kinetic data we calculated the ratios of the constants characterizing the reactivity of the redox pair anisic aldehyde-formaldehyde in the case of electrophilic assistance of the cation and without its assistance.

The Reaction between 4-Methoxybenzaldehyde and 2,3-Dimethylquinoxaline

The Reaction between 4-Methoxybenzaldehyde and 2,3-Dimethylquinoxaline