Oxygen Desaturation In Patients Research Articles

Nocturnal Arterial Oxygen Saturation Monitoring in Patients with Respiratory Disease

To find out the predictors of nocturnal arterial oxygen desaturation in patients with respiratory diseases, transcutaneous oxygen saturation(StcO2) monitoring studies using a pulse oximeter were performed during sleep in 20 patients. StcO2 was decreased more than 4% from the baseline value in 18 patients(90%) and more than 10%('Desaturator') in 8(40%). Five of the seven patients(71.4%) with awake PaO2<60mmHg and three of the thirteen patients(23.1%) with awake PaO2≥60mmHg were 'desaturators'. The awake PaO2/FIO2 and PaO2/PAO2 could distinguish 'desaturator' from 'nondesaturator, and PaO2, SaO2 or StcO2 could not. These results suggest that the nocturnal oxygen desaturation depends on the severity of the underlying disease rather than the baseline PaO2. Anthropomorphic and lung function factors could not separate between 'desaturator' and 'non-desaturator', and about a quarter of patients with a wake PaO2≥60mmHg developed significant desaturation. Therefore, it is necessary to monitor the nocturnal arterial oxygen saturation in patients with respiratory diseases regardless of their severity of airflow obstruction or awake PaO2.

Oxygen Desaturation in Patients During Commercial Jet Aircraft Repatriation

Oxygen Desaturation in Patients During Commercial Jet Aircraft Repatriation

Noctural oxygen desaturation in patients using long-term oxygen therapy for chronic airflow limitation

Nocturnal oxygen desaturation in patients receiving long-term oxygen therapy is described despite adequate daytime oxygenation (PaO2 greater than 8 kPa). Domiciliary oximetry overnight was performed on ten patients receiving long-term oxygen treatment for chronic airflow limitation: six patients were well saturated throughout the night with a fall in SaO2 to below 90% for only 1% of the monitoring time; four showed significant desaturation with a fall in SaO2 to below 90% for periods of 15-47% of the monitoring time.

Breathing Pattern Abnormalities and Arterial Oxygen Desaturation during Sleep in the Congestive Heart Failure Syndrome: Improvement following Medical Therapy

We observed breathing pattern abnormalities and arterial oxygen desaturation in patients with stable congestive heart failure during overnight polysomnography. To determine whether congestive heart failure was the reason for these abnormalities, we then studied six additional patients before and after treatment of heart failure. Breathing was more abnormal (153 +/- 87 episodes/night) during decompensation of heart failure and improved with medical therapy (72 +/- 100 episodes/night) (p less than 0.05). Abnormal breathing patterns resolved in three patients, improved in two, and were unchanged in one patient after therapy. Allographic cardiac transplantation in one patient whose sleep study remained unchanged after medical therapy was associated with resolution of breathing pattern abnormalities and severe desaturation during sleep. Therapy-related improvement in nocturnal respiratory events suggests congestive heart failure is a contributing factor for breathing abnormalities and arterial oxygen desaturation during sleep.

Effect of Chlormadinone Acetate on Sleep Arterial Oxygen Desaturation in Patients with Chronic Obstructive Pulmonary Disease

Twelve patients with chronic obstructive pulmonary disease (COPD) were studied in order to evaluate the effect of chlormadinone acetate (CMA), a potent synthetic progesterone, on the degree of hypoxemia during sleep. In patients designated as "correctors," in whom an increase in minute ventilation (VI) during wakefulness was brought about mainly by an increase in tidal volume (VT) and PaCO2 was effectively decreased by the administration of CMA, this agent also proved to be effective during sleep, with hypoxemia improved during both NREM and REM sleep. On the other hand, in patients called "noncorrectors" in whom a decrease in PaCO2 was not seen during wakefulness with CMA, there was also no effect during sleep. These results indicate that CMA is effective in certain selected patients with COPD.

Three patterns of oxygen desaturation in patients with sleep apnea syndromes

Three patterns of oxygen desaturation in patients with sleep apnea syndromes

Relationship of ventricular ectopy to nocturnal oxygen desaturation in patients with chronic obstructive pulmonary disease

Sudden death and oxyhemoglobin desaturation are known to occur during sleep in patients with chronic obstructive pulmonary disease. The present study was undertaken to determine the frequency with which nocturnal oxygen desaturation promotes an increase in ventricular ectopic activity, since such a relationship could represent a potential pathophysiologic mechanism for sudden death during sleep. Forty-two clinically stable subjects with moderately severe obstructive airways disease, mean ratio of one-second forced expiratory volume to forced vital capacity = 51 ± 12 percent, underwent overnight polygraphic sleep study. Oxyhemoglobin saturation was monitored by ear oximetry, and electrocardiographic leads CC5and CM5 were employed for arrhythmia detection. Premature ventricular complexes were detected in 27 (64 percent) of the subjects and were complex (multifocal, repetitive, or both) in 17. No significant relationship between premature ventricular complex frequency and arterial oxygen saturation was detected for the group as a whole. In part, this result can be attributed to the relatively mild hypoxemic stress experienced by the 22 subjects in whom arterial oxygen saturation remained greater than 80 percent. In contrast, six (30 percent) of the 20 patients who had desaturation to less than 80 percent showed a greater than 150 percent increase In premature ventricular complex frequency with oxygen desaturation. These results suggest that nocturnal hypoxemia, if of sufficient magnitude, is capable of Increasing ventricular ectopy during sleep in a substantial number of patients with chronic obstructive pulmonary disease.

Ventilation And Oxygenation Changes During Sleep In Cystic Fibrosis

Oxygen desaturation during sleep in patients with cystic fibrosis has been attributed to changes in the end-expiratory volume during rapid eye movement (REM) sleep, leading to worsening of the ventilation-perfusion distribution. The purpose of this study was to describe the changes in ventilation during sleep that may contribute to the oxygen desaturation. Six adolescent males with moderate to severe cystic fibrosis were studied. It was concluded that hypoventilation during REM may contribute to oxygen desaturation in patients with cystic fibrosis.

Nocturnal Oxygen Desaturation in Patients With Sickle Cell Anemia

The sleep of two patients with sickle cell disease was punctuated by periods with notably reduced arterial O2 saturation despite simultaneous normal respiratory rates. The O2 levels returned to baseline during intermittent wakefulness. Gas exchange patterns during sleep may contribute to the morbidity of sickle cell disease.

Nocturnal oxygen desaturation in patients with sickle cell anemia

Nocturnal oxygen desaturation in patients with sickle cell anemia

A radiographic method for measuring steady-state functional residual capacity in the supine patient. A method suitable for sleep studies.

We have devised a method to measure functional residual capacity (FRC) in the recumbent, spontaneously breathing patient. Simultaneous anteroposterior and lateral chest radiographs were exposed at the end of an exhalation, as determined by tracings of flow sensed by a nasal thermistor. The volume of the lungs was then planimetrically measured. Functional residual capacity was sequentially measured in 20 supine subjects, both by a helium dilution technique and by the radiographic technique. Planimetric measurement of FRC correlated well with the helium dilution technique, with a range of FRC measurements from 1.53 to 6.41 L (r = 0.94). This method of measuring lung volume should be useful in evaluating changes in FRC associated with different sleep stages and in explaining the mechanisms causing nocturnal oxygen desaturation in patients with chronic obstructive lung disease.

Disordered Breathing and Oxygen Desaturation during Sleep in Patients with Chronic Obstructive Pulmonary Disease

Patients with chronic obstructive pulmonary disease (COPD) often experience episodic oxygen desaturation during sleep, 1 Flick MR Block AJ Continuous in vivo monitoring of arterial oxygenation in chronic obstructive lung disease. Ann Intern Med. 1977; 86: 725-730 Crossref PubMed Scopus (87) Google Scholar , 2 Koo KW Sax DS Snider GL Arterial blood gases and pH during sleep in chronic obstructive pulmonary disease. Am J Med. 1975; 58: 663-670 Abstract Full Text PDF PubMed Scopus (112) Google Scholar , 3 Pierce AK Jarrett CE Werkle Jr, G et al. Respiratory function during sleep in patients with chronic obstructive lung disease. J Clin Invest. 1966; 45: 631-636 Crossref PubMed Scopus (31) Google Scholar , 4 Trask CH Cree EM Oximeter studies on patients with chronic obstructive emphysema, awake and during sleep. N Engl J Med. 1962; 266: 639-642 Crossref PubMed Scopus (63) Google Scholar although why this occurs is not known. Sleep-induced episodic oxygen desaturation is also seen in patients suffering from the sleep apnea syndrome. 5 Guilleminault C Tilkian A Dement WC The sleep apnea syndromes. Ann Rev Med. 1976; 27: 465-484 Crossref PubMed Scopus (1128) Google Scholar Such patients may experience hundreds of episodes of apnea during a single night's sleep, many of which may lead to desaturation. Sleep-disordered breathing, including periodic breathing and apnea, is also seen in some normal subjects, but to a limited extent. 5 Guilleminault C Tilkian A Dement WC The sleep apnea syndromes. Ann Rev Med. 1976; 27: 465-484 Crossref PubMed Scopus (1128) Google Scholar , 6 Webb P Periodic breathing during sleep. J Appl Physiol. 1974; 37: 899-903 Crossref PubMed Scopus (85) Google Scholar With these facts in mind, we recently demonstrated a relationship between sleep-disordered breathing and oxygen desaturation in patients with COPD who were monitored during daytime naps. 7 Wynne JW Block AJ Hunt LA et al. Sleep apnea during daytime naps in patients with chronic obstructive lung disease (COLD). Am Rev Respir Dis. 1977; 115 (abstract): 181 PubMed Google Scholar In the present study, we have extended our observations to include prolonged nocturnal sleep.

Physiological responses of rats to intermittent high-altitude stress: effects of age.

ArticlePhysiological responses of rats to intermittent high-altitude stress: effects of age.J J McGrath, J Procházka, V Pelouch, and B OstádalJ J McGrath, J Procházka, V Pelouch, and B OstádalPublished Online:01 Mar 1973https://doi.org/10.1152/jappl.1973.34.3.289MoreSectionsPDF (962 KB)Download PDF ToolsExport citationAdd to favoritesGet permissionsTrack citations ShareShare onFacebookTwitterLinkedInEmailWeChat Back to Top Next Download PDF FiguresReferencesRelatedInformationCited ByCardioprotective adaptation of rats to intermittent hypobaric hypoxia is accompanied by the increased association of hexokinase with mitochondriaPetra Waskova-Arnostova, Barbara Elsnicova, Dita Kasparova, Daniela Hornikova, Frantisek Kolar, Jiri Novotny, and Jitka Zurmanova15 December 2015 | Journal of Applied Physiology, Vol. 119, No. 12The Effect of Altitude-Induced Hypoxia on Heart Disease: Do Acute, Intermittent, and Chronic Exposures Provide Cardioprotection?High Altitude Medicine & Biology, Vol. 12, No. 1Mitochondrial nitric oxide metabolism during rat heart adaptation to high altitude: effect of sildenafil, l-NAME, and l-arginine treatmentsTamara Zaobornyj, Laura B. Valdez, Darío E. Iglesias, Manuel Gasco, Gustavo F. Gonzales, and Alberto Boveris1 June 2009 | American Journal of Physiology-Heart and Circulatory Physiology, Vol. 296, No. 6Effects of Intermittent Hypoxia on the HeartAntioxidants & Redox Signaling, Vol. 9, No. 6ANG II type 1 receptor antagonist irbesartan inhibits coronary angiogenesis stimulated by chronic intermittent hypoxia in neonatal ratsKarel Rakusan, Zuzana Chvojkova, Patricia Oliviero, Ivana Ostadalova, Frantisek Kolar, Catherine Chassagne, Jane-Lise Samuel, and Bohuslav Ostadal1 March 2007 | American Journal of Physiology-Heart and Circulatory Physiology, Vol. 292, No. 3Effects of aging on the cardiac remodeling induced by chronic high-altitude hypoxia in ratC. Chouabe, E. Ricci, J. Amsellem, S. Blaineau, Y. Dalmaz, R. Favier, J.-M. Pequignot, and R. Bonvallet1 September 2004 | American Journal of Physiology-Heart and Circulatory Physiology, Vol. 287, No. 3Intermittent Hypoxic Training Protects Canine Myocardium from Infarction29 November 2016 | Experimental Biology and Medicine, Vol. 229, No. 8Sleep and chronic obstructive pulmonary diseaseCurrent Opinion in Pulmonary Medicine, Vol. 10, No. 2Development of Cardiac Sensitivity to Oxygen Deficiency: Comparative and Ontogenetic AspectsBohuslav Ostadal, Ivana Ostadalova, and Naranjan S. Dhalla1 July 1999 | Physiological Reviews, Vol. 79, No. 3Predictors of nocturnal oxygen desaturation in patients with COPDRespiratory Medicine, Vol. 93, No. 3Splenic contraction-induced reversible increase in hemoglobin concentration in intermittent hypoxiaIchiro Kuwahira, Uguri Kamiya, Tokuzen Iwamoto, Yoshihiro Moue, Tetsuya Urano, Yasuyo Ohta, and Norberto C. Gonzalez1 January 1999 | Journal of Applied Physiology, Vol. 86, No. 1Depressed gluconeogenesis and ureogenesis in isolated hepatocytes after intermittent hypoxia in ratsInternational Journal of Biochemistry, Vol. 22, No. 11Threshold of intermittent hypoxia-induced right ventricular hypertrophy in the ratRespiration Physiology, Vol. 56, No. 2The activity of certain glycolytic enzymes of Japanese quail (Cotournix cotournix japonica) hatched at different temperaturesComparative Biochemistry and Physiology Part B: Comparative Biochemistry, Vol. 65, No. 4Acclimatization of newborn rats and guniea pig to 3000 to 5000 m stimulated altitudesRespiration Physiology, Vol. 36, No. 3 More from this issue > Volume 34Issue 3March 1973Pages 289-93 https://doi.org/10.1152/jappl.1973.34.3.289PubMed4265849History Published online 1 March 1973 Published in print 1 March 1973 Metrics