Oxindoles Research Articles

Synthesis and biological evaluation of novel oxindole derivatives for imaging neurofibrillary tangles in Alzheimer’s disease

This letter describes the synthesis and biological evaluation of a novel series of radioiodinated oxindole (OI) derivatives for detecting neurofibrillary tangles (NFTs) in the brains of patients with Alzheimer’s disease (AD). In binding experiments in vitro, 2-oxindole (2-OI) and 3-oxindole (3-OI) derivatives showed affinity for tau aggregates. The 3-OI derivative 14 showed the highest affinity of these derivatives. In biodistribution experiments using normal mice, the OI derivatives displayed good uptake (2.4–2.5%ID/g at 2min) and clearance from the brain with time (0.6–1.4%ID/g at 30min). In fluorescence staining experiments using AD brain sections, 14 clearly stained NFTs. 3-OI may serve as a new molecular scaffold for developing novel NFT imaging agents.

ChemInform Abstract: Synthesis of Oxindoles via Direct Photolysis of N‐(2‐Bromoaryl)alkanamides.

AbstractA simple, economic, radical‐initiator‐ and transition‐metal‐free method is used for the preparation of oxindoles, e.g. (II).

Hydroxylation of Oxindoles and β-Keto Esters Using DBFOX Ligand

Hydroxylation of Oxindoles and β-Keto Esters Using DBFOX Ligand

Synthesis of benzopyrano-triazolopyrimidine spirofused with an oxindole fragment

Synthesis of benzopyrano-triazolopyrimidine spirofused with an oxindole fragment

Unexpected 7‐Methylation of Oxindoles.

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.

Reactions of Hydroxyazolidines with π‐Donor Heterocycles. Part 3. Reaction of 1‐Acetyl‐5‐hydroxypyrazolidines with Oxindoles.

AbstractFor Abstract see ChemInform Abstract in Full Text.

Synthesis of 2,3′-biindolyls and indolo[3,2- a]carbazoles

Several highly activated 2,3′-biindolyls were prepared from methyl 5,6-dimethoxyindole-2-carboxylate and oxindoles. The 2,3′-biindolyls were further transformed into a hydroxy indolo[3,2- a]carbazole and a bisindole amide.

Infrared Spectroscopy of H-Bonded Bridges Stretched across the cis-Amide Group: I. Water Bridges

The water-containing clusters of oxindole (OI) and 3,4-dihydro-2(1H)-quinolinone (DQ) have been studied in the hydride stretch region of the infrared by the technique of resonant ion-dip infrared s...

Spectroscopy and photophysics of 1-phenylisatin and oxindole

The absorption and photoluminescence characteristics of 1-phenylisatin (PI) and oxindole (OI) were studied in different solvents at 300 K. In the basic solution a new absorption band system found for PI has been attributed to a structural change leading to formation of new species. Dual fluorescence for PI and OI in different solvents was explained as normal 1B 2u → 1A 1g transition and the other well-structured band as an anomalous band. This large Stokes shifted anomalous band of PI in water and alcohol was explained as fluorescence emission from a state formed due to solute–solvent relaxation producing a sort of critical inversion. Studies in different solvents including a β-cyclodextrin solution revealed that in suitable active medium PI has all the properties to be potential laser dye.

Formation of 3,3,5,7-tetranitrooxindole and 3,5,7-trinitroindazole by nitration of oxindole

Nitration (HNO 3/H 2SO 4) of oxindole gave 3,3,5,7-tetranitrooxindole ( 1c), which readily underwent ring-opening and decarboxylation to 4,6-dinitro-2-(dimtromclhyl)aniline ( 4b), which in turn could be cyclized to 3,5,7-triniuoindazole (5).

P124 new hetetocyclic systems from dihydropyrano[3,4-b] indolones

P124 new hetetocyclic systems from dihydropyrano[3,4-b] indolones

Improvements in the Total Synthesis of Physostigmine: Reductive Cyclization of Oxindoles to Tricyclic Indoleninepyrrolidines with Lithium Aluminium Hydride in Tetrahysrofuran

Reduction cyclisante de cyanomethyl-3- ou ethoxycarbonylamino-2' ethyl-3 indolinones-2; obtention d'analogues de l'eserine

The Synthesis of Spiro-(cyclopentane-1,3'-oxindol)-derivatives

The Synthesis of Spiro-(cyclopentane-1,3'-oxindol)-derivatives

SYNTHESIS OF E- AND Z-ISOMERS OF 3-(α-THIOETHOXYMETHYLENE)OXINDOLE: CHARACTERIZATION AND RELATIVE STABILITY OF THE TWO ISOMERS

Abstract The E- and Z-isomers of 3-(α-thioethoxymethylene)oxindole have been synthesized for the first time and the verification that the E-isomer is more stable than the Z-isomer is provided experimentally.

Condoxine: A novel oxindole system from secologanin aglycone.

Condoxine: A novel oxindole system from secologanin aglycone.

Substituted oxindoles. 3. Synthesis and pharmacology of some substituted oxindoles.

Substituted oxindoles. 3. Synthesis and pharmacology of some substituted oxindoles.

The origin of the CN group of benzonitrile formed on pyrolysis of oxindole at 850°

The origin of the CN group of benzonitrile formed on pyrolysis of oxindole at 850°

Uncarine C, D (speciophylline), E, and F: C-3 and C-7 epimeric oxindoles related to tetrahydroalstonine

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Intramolecular reactions in the oxindole series

Es werden verschiedene Reaktionen in der Oxindolreihe diskutiert. Man kann sie sich als ahnliche Mechanismen vorstellen, da alle uber intramolekular gebildete Zwischenprodukte bzw. Endprodukte laufen.

767. Oxindoles formerly regarded as ψ-indoxyls

767. Oxindoles formerly regarded as ψ-indoxyls