The study aimed to explore appropriate flotation reagents to recover copper minerals from a high content of slime and refractory oxidized copper ores. Based on the research on the properties of the material, the reagent regime was investigated and a technological flowsheet consisting of one roughing flotation, two concentrate flotation, three scavenging flotation and one concentrate-scavenging flotation was adopted to perform the closed circuit floatation experiment. The optimum depressor of flotation experiment was determined as CHO, activator as (NH4)2SO4 and collector as isoamyl xanthogenate. Under such a condition of reagent types and their appropriate reagent dosages, a copper recovery of 75.03% with a concentrate grade of 18.01% was obtained.