Oxidatively modified low-density lipoprotein (OxLDL) has been implicated in a range of disorders, including certain cardiovascular, metabolic, and immunological diseases. The bioactive oxidation products of this lipoprotein include a vast array of oxidized lipids, sterols, and triglycerides. Some of these species may play a significant role in the pathophysiological effects observed at elevated OxLDL concentrations. However, the particular biological effects of specific OxLDL components, as well as the mechanisms by which they elicit these responses, are poorly understood. To elucidate some of the effects of OxLDL, we undertake a molecular-scale investigation of changes induced in endothelial membranes in the presence of various oxidation products. Specifically, in order to disaggregate the individual effects of particular oxidized species, we utilize coarse-grained molecular dynamics simulations. With this technique, we probe alterations to the biomechanical properties (structure and dynamics) of multi-component model membranes by compounds that have been previously shown, through experimental means, to induce endothelial stiffening. This study may begin to clarify some of the molecular mechanisms underlying endothelial cell dysfunction resulting from exposure to OxLDL.