Oxidative Ion Research Articles

Protective Effects of Chlorogenic Acid Against Amyloid-Beta-Induced Oxidative Stress and Ion Transport Dysfunction in SH-SY5Y Cells.

Caloric restriction mimetics mimic the beneficial effects of dietary restriction approaches, such as caloric restriction approaches, without limiting the dietary intake. Chlorogenic acid (CGA) acts as a caloric restriction mimetic; however, its neuroprotective mechanisms remain ambiguous. Therefore, in this study, we aimed to elucidate the neuroprotective effects of CGA on SH-SY5Y cells treated with amyloid-beta (Aβ)1-42. Aβ1-42 (1.25 μM) induced oxidative stress by significantly increasing the pro-oxidant levels and decreasing the antioxidant levels in the cells. Additionally, it decreased the Na+/K+-ATPase and Ca2+-ATPase ion transporter activities and enhanced the acetylcholinesterase activity. However, CGA (100 μM) reversed these Aβ1-42-induced changes in SH-SY5Y cells. Overall, CGA exerted neuroprotective effects against Aβ1-42-induced oxidative stress and impaired ion transporter and acetylcholinesterase activities, serving as a promising therapeutic candidate for neurodegenerative diseases, such as Alzheimer's disease.

Multi-Omics Analysis of Exogenous Potassium (K+)’s Role in Alleviating Trehalose Effects Under NaCl Stress in Tamarix ramosissima

Salt stress significantly impacts plant growth, and Tamarix ramosissima Ledeb is utilized for afforestation in China’s saline–alkali regions. Trehalose, an osmoregulatory compound, enhances plant tolerance to salt stress by stabilizing cell membranes and regulating oxidative states and ion distribution. However, its role in mitigating NaCl-induced damage in Tamarix species remains understudied. In this study, root samples of T. ramosissima were exposed to NaCl stress with exogenous K+ at 0 h, 48 h, and 168 h. Analyses revealed that soluble sugar content increased over time, especially in the 200 mM NaCl + 10 mM KCl treatment at 168 h. Transcriptome sequencing identified 19 trehalose-related genes involved in metabolic and sucrose pathways, with Unigene0015746 notably enhancing D-Glucose 6-phosphate accumulation, a key precursor for trehalose synthesis. This gene emerged as a crucial candidate for further research. The transcriptome data were validated using qRT-PCR. Overall, the study elucidates the molecular mechanisms of trehalose-related genes in T. ramosissima under salt stress with exogenous K+, providing valuable genetic resources for breeding salt-tolerant tree species.

Allantoin regulated oxidative defense, secondary metabolism and ions homeostasis in maize (Zea mays L.) under heat stress

Allantoin regulated oxidative defense, secondary metabolism and ions homeostasis in maize (Zea mays L.) under heat stress

Kaixinsan alleviates adriamycin-induced depression-like behaviors in mice by reducing ferroptosis in the prefrontal cortex

To investigate the effect of Kaixinsan (KXS, a traditional Chinese medicine formula) for alleviating adriamycin-induced depression-like behaviors in mice bearing breast cancer xenografts and explore the pharmacological mechanism. Forty female BALB/c mice were randomized equally into control group, model group, and low- and high-dose KXS treatment groups, and in the latter 3 groups, mouse models bearing orthotopic breast cancer 4T1 cell xenografts were established and treated with adriamycin along with saline or KXS via gavage. Depression-like behaviors of the mice were assessed using open field test and elevated plus-maze test, and the changes in serum levels of depression-related factors were examined. RNA-seq analysis and transmission electron microscopy were used and ferroptosis-related factors were detected to explore the mechanisms of adriamycin-induced depression and the therapeutic mechanism of KXS. The results were verified in SH-SY5Y cells using ferroptosis inhibitor Fer-1 as the positive control. KXS significantly alleviated depression-like behaviors and depression-related serological changes induced by adriamycin in the mouse models. RNA-seq results suggested that KXS alleviated chemotherapy-induced depression by regulating oxidative stress, lipid metabolism and iron ion binding in the prefrontal cortex. Pathological analysis and detection of ferroptosis-related factors showed that KXS significantly reduced ferroptosis in the prefrontal cortex of adriamycin-treated mice. In SH-SY5Y cells, both KXS-medicated serum and the ferroptosis inhibitor were capable of attenuating adriamycin-induced cell ferroptosis. KXS alleviates adriamycininduced depression-like behaviors in mice by reducing ferroptosis in the prefrontal cortex of breast cancer-bearing mice.

Foliar-applied sulfur is supplemental to soil application in alleviating waterlogging stress through the mitigation of oxidative stress and ion homeostasis in rapeseed (Brassica napus L.)

Waterlogging has appeared as a major issue for agricultural production and has an adverse effect on rapeseed growth. A pot experiment was conducted to investigate the effect of soil and/or foliar applied S in alleviating the waterlogging stress in rapeseed (Brassica napus L. cv. Campino). The experiment treatments included, no soil S application (-SS), soil S fertilization (SS, 70 mg S kg−1 soil as MgSO4), foliar S application (FS, 300 ppm MgSO4) and both soil and foliar application of S (SS+FS). All the treatments were subjected to normal soil water (control) and waterlogged condition. Foliar S was applied two days prior to the onset of waterlogging treatment, which was imposed at vegetative stage (BBCH-31) for 7 days. The results demonstrated that without foliar S application, both unfertilized (-S) and S-fertilized (+S) waterlogged plants showed elevated level of hydrogen peroxide (35 % and 15 %) and malondialdehyde (84 % and 101 %) and reduced nutrients uptake, net photosynthesis and plant growth compared to their non-waterlogged counterparts. Although all S treatments alleviated the suppressing effects of waterlogging stress, the alleviative effect of soil plus foliar applied S was higher than these individual treatments. It increased dry matter by 17 %, superoxide dismutase activity by 15 %, catalase activity by 15 %, glutathione reductase activity by 14 %, ascorbate peroxidase activity by 18 %, ascorbate content by 19 %, glutathione content by 28 %. The increase in the growth and antioxidant activities of the soil plus foliar S supplemented plants was attributed to the increase in the contents of some nutrients (S 8 %, P 18 %, Mg 9 %, Zn 13 %) and net photosynthesis rate (19 %), whereas decrease in hydrogen peroxide (15 %), malondialdehyde (20 %), oxidized glutathione content (9 %), dehydroascorbic acid content (5 %) compared with untreated (without foliar-S) waterlogged plants. Collectively, the study concludes that foliar-S application supplements soil S fertilization in alleviating waterlogging stress in rapeseed plants, through inducing physiological and biochemical resistance, and improving homeostasis as well.

Heavy metals and elderly kidney health: A multidimensional study through Enviro-target Mendelian Randomization

Chronic Kidney Disease (CKD), closely linked to environmental factors, poses a significant public health challenge. This study, based on 529 triple-repeated measures from key national environmental pollution area and multiple gene-related public databases, employs various epidemiological and bioinformatics models to assess the impact of combined heavy metal exposure (Chromium [Cr], Cadmium [Cd], and Lead [Pb]) on early renal injury and CKD in the elderly. Introducing the novel Enviro-Target Mendelian Randomization method, our research explores the causal relationship between metals and CKD. The findings indicate a positive correlation between increased levels of metal and renal injury, with combined exposure caused renal damage more significantly than individual exposure. The study reveals that metals primarily influence CKD development through oxidative stress and metal ion resistance pathways, focusing on three related genes (SOD2, MPO, NQO1) and a transcription factor (NFE2L2). Metals were found to regulate oxidative stress levels in the body by increasing the expression of SOD2, MPO, NQO1, and decreasing NFE2L2, leading to CKD onset. Our research establishes a new causal inference framework linking environmental pollutants-pathways-genes-CKD, assessing the impact and mechanisms of metal exposure on CKD. Future studies with more extensive in vitro evidence and larger population are needed to validate.

Nutrient Recovery from Algae Using Mild Oxidative Treatment and Ion Exchange

Nutrient Recovery from Algae Using Mild Oxidative Treatment and Ion Exchange

Ameliorative impacts of astaxanthin against atrazine-induced renal toxicity through the modulation of ionic homeostasis and Nrf2 signaling pathways in mice.

Astaxanthin (ASX), a red pigment belonging to carotenoids, has antioxidant activity and anti-oxidative stress effect. Atrazine (ATZ), a frequently used herbicide, whose degradation products are the cause for nephrosis and other oxidative stress associated diseases. This study was aimed to reveal the potential protective mechanism of astaxanthin against atrazine-induced nephrosis. Atrazine was orally given (250mg/kg bw) to the mice along with astaxanthin (100mg/kg bw) for 28days. Serum biochemical indicators, oxidative stress biomarkers, ATPase activities, ion concentration, histomorphology, and various renal genes expression linked with apoptosis, Nrf2 signaling pathway, and aquaporins (AQPs) were assessed. It was found that serum creatinine (SCr), blood urea nitrogen (BUN), and MDA levels were significantly increased after the treatment of atrazine, whereas serum renal oxidative stress indicators like CAT, GSH, T-AOC, SOD decreased. Renal histopathology showed that atrazine significantly damaged renal tissues. The activities of Ca 2+-Mg 2+-ATPase were increased whereas Na +-K +-ATPase decreased significantly (P<0.05). Moreover, results confirmed that the expression of AQPs, Nrf2, and apoptosis genes were also altered after atrazine administration. Interestingly, astaxanthin supplementation significantly (P<0.05) improved atrazine-induced nephrotoxicity via decreasing SCr, BUN, oxidative stress, ionic homeostasis and reversing the changes in AQPs, Nrf2, and apoptosis gene expression. These findings collectively suggested that astaxanthin has strong potential ameliorative impact against atrazine induced nephrotoxicity.

Functional Polyphenol-Based Nanoparticles Boosted the Neuroprotective Effect of Riluzole for Acute Spinal Cord Injury.

Riluzole is commonly used as a neuroprotective agent for treating traumatic spinal cord injury (SCI), which works by blocking the influx of sodium and calcium ions and reducing glutamate activity. However, its clinical application is limited because of its poor solubility, short half-life, potential organ toxicity, and insufficient bioabilities toward upregulated inflammation and oxidative stress levels. To address this issue, epigallocatechin gallate (EGCG), a natural polyphenol, was employed to fabricate nanoparticles (NPs) with riluzole to enhance the neuroprotective effects. The resulting NPs demonstrated good biocompatibility, excellent antioxidative properties, and promising regulation effects from the M1 to M2 macrophages. Furthermore, an in vivo SCI model was successfully established, and NPs could be obviously aggregated at the SCI site. More interestingly, excellent neuroprotective properties of NPs through regulating the levels of oxidative stress, inflammation, and ion channels could be fully demonstrated in vivo by RNA sequencing and sophisticated biochemistry evaluations. Together, the work provided new opportunities toward the design and fabrication of robust and multifunctional NPs for oxidative stress and inflammation-related diseases via biological integration of natural polyphenols and small-molecule drugs.

Possible Role of Cellular Polyamine Metabolism in Neuronal Apoptosis.

Recent studies have shown that cellular levels of polyamines (PAs) are significantly altered in neurodegenerative diseases. Evidence from in vivo animal and in vitro cell experiments suggests that the cellular levels of various PAs may play important roles in the central nervous system through the regulation of oxidative stress, mitochondrial metabolism, cellular immunity, and ion channel functions. Dysfunction of PA metabolism related enzymes also contributes to neuronal injury and cognitive impairment in many neurodegenerative diseases. Therefore, in the current work, evidence was collected to determine the possible associations between cellular levels of PAs, and related enzymes and the development of several neurodegenerative diseases, which could provide a new idea for the treatment of neurodegenerative diseases in the future.

Isolation and characterization of multiple-stress tolerant bacteria from radon springs.

Radon springs, characterized by their high concentrations of radon gas (Rn222), are extreme environments with unique physicochemical conditions distinct from conventional aquatic ecosystems. Our research aimed to investigate microbial life in radon springs, focusing on isolating extremophilic bacteria and assessing their resistance to adverse conditions. Our study revealed the prevalence of Actinomycetia species in the radon spring environment. We conducted various tests to evaluate the resistance of these isolates to oxidative stress, irradiation, desiccation, and metal ion content. These extremophilic bacteria showed overall higher resistance to these stresses compared to control strains. Lipidomic analysis was also employed to provide insights into the adaptive mechanisms of these bacteria which were found mainly in the correlations among individual clusters and changes in content of fatty acids (FA) as well as differences between content and type of FAs of environmental isolates and type strains.

Oxidative stress and ion channels in neurodegenerative diseases.

Numerous neurodegenerative diseases result from altered ion channel function and mutations. The intracellular redox status can significantly alter the gating characteristics of ion channels. Abundant neurodegenerative diseases associated with oxidative stress have been documented, including Parkinson's, Alzheimer's, spinocerebellar ataxia, amyotrophic lateral sclerosis, and Huntington's disease. Reactive oxygen and nitrogen species compounds trigger posttranslational alterations that target specific sites within the subunits responsible for channel assembly. These alterations include the adjustment of cysteine residues through redox reactions induced by reactive oxygen species (ROS), nitration, and S-nitrosylation assisted by nitric oxide of tyrosine residues through peroxynitrite. Several ion channels have been directly investigated for their functional responses to oxidizing agents and oxidative stress. This review primarily explores the relationship and potential links between oxidative stress and ion channels in neurodegenerative conditions, such as cerebellar ataxias and Parkinson's disease. The potential correlation between oxidative stress and ion channels could hold promise for developing innovative therapies for common neurodegenerative diseases.

Desalination brine effects beyond excess salinity: Unravelling specific stress signaling and tolerance responses in the seagrass Posidonia oceanica.

Desalination has been proposed as a global strategy for tackling freshwater shortage in the climate change era. However, there is a concern regarding the environmental effects of high salinity brines discharged from desalination plants on benthic communities. In this context, seagrasses such as the Mediterranean endemic and ecologically important Posidonia oceanica have shown high vulnerability to elevated salinities. Most ecotoxicological studies regarding desalination effects are based on salinity increments using artificial sea salts, although it has been postulated that certain additives within the industrial process of desalination may exacerbate a negative impact beyond just the increased salinities of the brine. To assess the potential effect of whole effluent brines on P. oceanica, mesocosm experiments were conducted within 10 days, simulating salinity increment with either artificial sea salts or brines from a desalination plant (at 43 psμ, 6 psμ over the natural 37 psμ). Morphometrical (growth and necrosis), photochemical (PSII chlorophyll a fluorometry), metabolic, such as hydrogen peroxide (H2O2), thiobarbituric reactive substances (TBARS) and ascorbate/dehydroascorbate (ASC/DHA), and molecular (expression of key tolerance genes) responses were analyzed in each different treatment. Although with a still positive leaf growth, associated parameters decreased similarly for both artificial sea salt and brine treatments. Photochemical parameters did not show general patterns, although only P. oceanica under brines demonstrated greater energy release through heat (NPQ). Lipid peroxidation and upregulation of genes related to oxidative stress (GR, MnSOD, and FeSOD) or ion exclusion (SOS3 and AKT2/3) were similarly incremented on both hypersalinity treatments. Conversely, the ASC/DHA ratio was significantly lower, and the expression of SOS1, CAT, and STRK1 was increased under brine influence. This study revealed that although metabolic and photochemical differences occurred under both hypersalinity treatments, growth (the last sign of physiological detriment) was similarly compromised, suggesting that the potential effects of desalination are mainly caused by brine-associated salinities and are not particularly related to other industrial additives.

Screening and identification of genes related to ferroptosis in keratoconus

Corneal keratoconus (KC) is a dilated (ectatic) corneal disease characterized by a central thinning of the cornea, which causes protrusion into a conical shape that seriously affects vision. However, due to the complex etiology of keratoconus, its entire mechanism remains unclear and there is no mechanism-directed treatment method. Ferroptosis is a novel programmed cell death mechanism related to lipid peroxidation, stress, and amino acid metabolism, which plays a crucial role in various diseases. This study aimed to explore the relationship between keratoconus and ferroptosis, to provide new insights into the mechanism of keratoconus development, and potential treatment options based on further elucidation of this mechanism. The corresponding mRNA microarray expression matrix data of KC patients were obtained from GEO database (GSE204791). Weighted co-expression network analysis (WGCNA) and support vector machine recursive feature elimination (SVM-RFE) were selected to screen hub genes, which were overlapped with ferroptosis genes (FRGs) from FerrDb. GO and GSEA were performed to analyze differential pathways, ssGSEA was used to determine immune status, and then, feasible drugs were predicted by gene-drug network. Additionally, we predicted the miRNA and IncRNA of hub genes to identify the underlying mechanism of disease so as to predict treatment for the disease. The epithelial transcriptome from keratoconus tissue mRNA microarray data (GSE204791) was extracted for the main analysis, including eight epithelial cells and eight epithelial control cells. The differential genes that were overlapped by WGCAN, SVM-RFE and FRGs were mainly related to oxidative stress, immune regulation, cellular inflammation, and metal ion transport. Through further analysis, aldo–keto reductase family 1 member C3 (AKR1C3) was selected, and negatively correlated with mature CD56 natural killer (NK) cells and macrophages. Then, gene-drug interaction network analysis and miRNA prediction were performed through the website. It was concluded that four immune-related drugs (INDOMETHACIN, DAUNORUBICIN, DOXORUBICIN, DOCETAXEL) and a miRNA (has-miR-184) were screened to predict potential drugs and targets for disease treatment. To our knowledge, this was the first report of KC being associated with ferroptosis and prompted search for differential genes to predict drug targets of gene immunotherapy. Our findings provided insight and a solid basis for the analysis and treatment of KC.

In-situ preparation of chemically-crosslinked polyvinylpyrrolidone gel polymer electrolyte for lithium ion battery via room-temperature electron beam-induced gelation

In this research, we report an initiator-free and room-temperature 2.5 MeV electron beam (EB)-induced gelation strategy to in-situ create polyvinylpyrrolidone-based gel polymer electrolytes (PVP-GPEs) in a fully-assembled lithium ion battery (LIB). A radiation-sensitive liquid precursor consisting of 1-vinyl-2-pyrrolidone (VP), poly (ethylene glycol) diacrylate (PD), and LiClO4 liquid electrolyte (LE) was effectively converted to freestanding PVP-GPEs even at an absorbed dose of 2 kGy (Irradiation time of 6 s). The formed GPE at the absorbed dose of 2 kGy exhibited good thermal stability and mechanical integrity while providing good electrochemical oxidative stability (up to 4.7 V) and ion conductivity (2.03 × 10−3 S/cm at 25 °C). Moreover, the LiCoO2/PVP-GPE/graphite coin cell in-situ prepared at the absorbed dose of 2 kGy showed comparable retention capacity to that of an LE-based coin cell after 50 cycles. The findings of this study suggest that the proposed in-situ quick EB-induced gelation strategy (without use of an initiator and thermal treatment) could be a scalable way to allow high-throughput production of reasonably performing and safe LIBs.

Multilayer composite nanofibrous film accelerates the Li+ diffusion for quasi-solid-state lithium-ion batteries

The rational design of dense and flexible solid-state electrolytes (SSEs) with interface compatibility is still challenging. Here, we report a three-layer dense 3D nanofibrous matrix (PCOF) by constructing a nanofiber framework combining polyacrylonitrile (PAN) and fast Li-ion conductor covalent organic frameworks (COFs) by electrospinning method. PCOF film can maintain an extraordinary electrolyte/electrode interface and an interconnected ion-conduction pathway, accelerating Li+ diffusion. The PCOF quasi-solid-state electrolyte (QSSE) has high oxidative stability (4.70 V, versus Li+/Li) and ion conductivity of 2.94×10−4 S cm−1 at room temperature. Lithium-ion battery based on PCOF QSSE with LiFPO4 (LFP) cathode exhibits outstanding rate characteristics and cycling stability. This multi-layer composite strategy will start a new area of QSSEs lithium-ion electrolytic devices, and simultaneously accelerate the design of electrolytes featuring a wide range of properties.

Comparative physiological and transcriptome analysis in cultivated and wild sugarcane species in response to hydrogen peroxide-induced oxidative stress

BackgroundSugarcane is an important energy crop grown worldwide,supplementing various renewable energy sources. Cultivated and wild sugarcane species respond differently to biotic and abiotic stresses. Generally, wild species are tolerant to various abiotic stresses. In the present study, the physiological and molecular responses of cultivated and wild sugarcane species to oxidative stress at the transcriptional levels were compared. Transcriptional responses were determined using RNAseq. The representative RNA-seq transcript values were validated by reverse transcriptase quantitative polymerase chain reaction (RT-qPCR) and confirmed through physiological responses.ResultsOxidative stress causes leaf-rolling and -tip drying in cultivated sugarcane, but the wild species are tolerant. Higher chlorophyll fluorescence was observed in the wild species than that in the cultivated varieties under stress. Wild species can maintain a higher chlorophyll stability index than the cultivated species, which was confirmed by the lower transcripts of the chlorophyllase gene in the wild species than that in the cultivated variety. Transcription factor genes (NAC, MYB, and WRKY) were markedly expressed in response to oxidative stress, revealing their involvement in stress tolerance. The analysis revealed synchronized expression of acetyl-transferase, histone2A, cellulose synthase, and secondary cell wall biosynthetic genes in the wild species. The validation of selected genes and 15 NAC transcription factors using RT-qPCR revealed that their expression profiles were strongly correlated with RNA-seq. To the best of our knowledge, this is the first report on the oxidative stress response in cultivated and wild sugarcane species.ConclusionPhysiological and biochemical changes in response to oxidative stress markedly differ between cultivated and wild sugarcane species. The differentially expressed stress-responsive genes are grouped intothe response to oxidative stress, heme-binding, peroxidase activity, and metal ion binding categories. Chlorophyll maintenance is a stress tolerance response enhanced by the differential regulation of the chlorophyllase gene.There is a considerable difference in the chlorophyll stability index between wild and cultivated varieties. We observed a substantial regulation of secondary wall biosynthesis genes in the wild species compared with that in the cultivated variety, suggesting differences in stress tolerance mechanisms.

Ferritin: Structure, Mechanism, Neuroferritinopathy in Human Body

When functioning well, ferritin plays a significant role in human body functioning as it helps to store and release iron ions to maintain human body stability. Otherwise, ferritin may fail in storing or release extra highly oxidative iron ions at different brain tissues, resulting in diseases such as neuroferritinopathy. Neuroferritinopathy is caused by gene mutations through two kinds of FTL genes. It can be inherited through genes and is autosomal dominant. Without paying efforts in tackling this diseases, more and more patients will suffer from its symptoms within generations. These symptoms will affect their daily physical movement and even personalities. Because neuroferritinopathy is caused by oxidative damage, anti-oxidation method therefore might be effective. Inheritance can be prevented by utilizing DNA polymerase or mismatch excision prepare enzymes for eggs and sperms.

Designing multi-target-directed flavonoids: a strategic approach to Alzheimer's disease.

The underlying causes of Alzheimer's disease (AD) remain a mystery, with multiple pathological components, including oxidative stress, acetylcholinesterase, amyloid-β, and metal ions, all playing a role. Here we report a strategic approach to designing flavonoids that can effectively tackle multiple pathological elements involved in AD. Our systematic investigations revealed key structural features for flavonoids to simultaneously target and regulate pathogenic targets. Our findings led to the development of a highly promising flavonoid that exhibits a range of functions, based on a complete structure-activity relationship analysis. Furthermore, our mechanistic studies confirmed that this flavonoid's versatile reactivities are driven by its redox potential and direct interactions with pathogenic factors. This work highlights the potential of multi-target-directed flavonoids as a novel solution in the fight against AD.

Selenium Oxoanions Removal from Wastewater by MoS42− Intercalated FeMgAl LDH: Catalytic Roles of Fe and Mechanism Insights

FeMgAl−MoS4 LDH was successfully synthesized by a one-pot hydrothermal process followed by ion-exchange methods, and this novel adsorbent was first conducted for aqueous selenite and selenate elimination. The Fe as a component for metal cation layers of LDHs could modulate the layer charge density, leading to more functional groups inserted into layers, and more importantly, this heterogeneous Fe can catalyze the surface reactions between Se(IV) or Se(VI) with S(-II) for oxoanions sequestration. The mechanisms are ion exchange between functional groups with HSeO3− and SeO32− for Se(IV) or SeO42− for Se(VI), followed by reduction by S(-II) from MoS42− groups. The existence of Fe in LDH cation layers, obviously enhanced the reactions (almost two times more for Se(IV) and three times more for Se(VI), respectively), resulting in satisfying adsorption capacities of 483.9 mg/g and 167.2 mg/g for Se(IV) and Se(VI), respectively. Mechanisms were further revealed by elementary analysis, XRD, FT−IR, SEM−EDX, and XPS, as well as the quantitative study. For sorption kinetics, the calculated values of capacities from the pseudo-second-order model are much closer to the experimental values. For sorption isotherms, Langmuir is better than the Freundlich isotherms model for closer capacities (505 mg/g for selenite and 172 mg/g for selenate). All these results demonstrated that the presence of heterogeneous Fe could catalyze the reduction of Se (IV/VI) for the aqueous system, and maybe other high oxidative states hazardous ions. So FeMgAl−MoS4 is a kind of novel adsorbent that offers a promising multi-functional and highly efficient solution for water selenium purification.