Manganese Oxide Research Articles

Graphene wrapped porous polyaniline/manganese oxide nanocomposites with enhanced structural stability and conductivity for high‐performance symmetric supercapacitor

AbstractManganese oxides have emerged as promising electrode materials for supercapacitors. Despite extensive efforts to improve their conductivity and structural stability through various manganese oxide/conductor nanocomposites, achieving efficient and reliable energy storage electrode materials has remained challenging. In this study, we propose a meticulous “dual enhancement” strategy, where three‐dimensional (3D) nanostructured polyaniline/manganese oxide composites (PM) are synthesized via an in situ method and further integrated with graphene wrapping to form polyaniline/manganese oxide/graphene nanocomposites (PMG). Electrochemical characterization reveals that PMG exhibits a remarkable specific capacitance of up to 403 F g−1 (at 1 A g−1), with a favorable capacitance retention of 80.2% after 5000 cycles, along with a wide potential window. This enhancement is attributed to the synergistic effects of polyaniline, which provides a supportive framework and electron transport pathways, and graphene, which offers external protection and enhances conductivity pathways. Assembled symmetrical supercapacitors demonstrate outstanding energy density (32.7–23.3 Wh kg−1) and power density (720–4500 W kg−1) at a high operating voltage of 1.8 V, surpassing the performance of many reported high‐performance supercapacitors. This study provides valuable insights for advancing manganese oxide electrode materials and is expected to catalyze their widespread adoption in energy storage applications.Highlights “Dual enhancement” is implemented by PANI supporting and rGO wrapping. The conductivity and structural stability of composite electrode is greatly enhanced. Improved capacitance (403 F g−1, 1 A g−1) and cycling stability (80.2%) is achieved. The symmetrical supercapacitor has high voltage and energy density (32.7 Wh kg−1).

Development of polyfunctionalized biochar modified with manganese oxide and sulfur for immobilizing Hg(II) and Pb(II) in water and soil and improving soil health

Mercury (Hg) and lead (Pb) pose significant risks to human health due to their high toxicity and bioaccumulative properties. This study aimed to develop a novel biochar composite (HMB-S), polyfunctionalized with manganese dioxide (α-MnO2) and sulfur functional groups, for the effective immobilization of Hg(II) and Pb(II) from contaminated environments. HMB-S demonstrated superior adsorption capacities of 190.1 mg/g for Hg(II) and 259.9 mg/g for Pb(II), which significantly surpasses the capacities of unmodified biochar (HB) and biochar functionalized solely with Mn (HMB). Mechanistic studies revealed that the immobilization of these metals by HMB-S involved ion exchange, mineral precipitation, surface complexation, and electrostatic interactions. In soil incubation experiments, HMB-S significantly decreased the levels of extractable Hg(II) and Pb(II) compared to the control, reducing the mobility of these metals and converting 17 % of Hg(II) and 26 % of Pb(II) into less bioavailable residual forms. Pot experiments confirmed that all tested biochar materials (HB, HMB, and HMB-S) promoted spinach growth in contaminated soils, with HMB-S being the most effective at lowering Hg(II) and Pb(II) uptake by plants. Additionally, analysis of soil microbial communities indicated that HMB-S altered community composition and increased the relative abundance of metal-resistant bacteria. These findings highlight the potential of polyfunctionalized biochar HMB-S as an effective remediation strategy for Hg and Pb contamination in soil and aqueous environments.

Thermodynamic Justification for the Effectiveness of the Oxidation—Soda Conversion of Ilmenite Concentrates

This article presents the results of a thermodynamic analysis of the oxidation soda conversion reactions of minerals in ilmenite concentrates in the temperature range of 373–2273 K. The thermodynamic parameters of pseudorutile, pseudobrukite, and the new minerals, zhikinite and spessartine, were calculated for the first time. It has been established that the most important criterion relating to the stability of titanium minerals and related elements, as well as the reaction properties of the structural oxides of metals and silicon, is their degree of oxidation. Oxides of silicon (IV) and manganese have the best reactivity in solid-phase oxidizing alkaline environments (VI). Modeling this process scientifically substantiates the mechanism involved in the destruction of minerals in ilmenite concentrates in the low-temperature region in the presence of atmospheric oxygen and sodium oxide of soda ash, which are decomposed through the absorption of heat and the evaporation of moisture during the dehydration of hydrated minerals of iron and manganese and the dehydration of the soda–ilmenite batch. Tests conducted during pilot metallurgical production at the Institute of Metallurgy and Enrichment (PMP of JSC) confirmed the feasibility of processing high-chromium and siliceous rutile leucoxene ilmenite concentrates, which are unsuitable for traditional pyro- and hydro-metallurgical enrichment methods, through single-stage oxidation soda roasting, followed by the leaching of easily soluble sodium salts of iron and associated impurities with water and a dilute hydrochloric acid solution. The proposed energy-saving method ensures the production of high-purity (>98%) synthetic rutile while eliminating the formation of strong deposits on the lining of roasting units.

Zr-Doped High-Voltage Spinel LiNi0.5Mn1.5O4 Manufactured via the Coprecipitation Method.

Lithium nickel manganese oxide (LiNi0.5Mn1.5O4, LNMO) provides an elevated operating potential of 4.7 V and a theoretical capacity of 147 mAh g-1, without the need for expensive cobalt. Zr-doped LNMO was synthesized using the coprecipitation technique with Couette-Taylor flow. FE-SEM images and TEM SAED patterns revealed that Zr-doped LNMO formed truncated octahedral structures with exposed (100) crystal facets. When compared to undoped LNMO, Zr-doped LNMO exhibited superior electrochemical performance. Electrochemical evaluations showed that Zr0.1-LNMO achieved 85.9% rate capability at 10 C, significantly outperforming the 69.1% of bare LNMO. In addition, Zr0.1-LNMO exhibited high stability, maintaining 76.8% of the discharge capacity even after 100 cycles.

A Universal Plug-and-Play Approach to In Situ Multinuclear Magnetic Resonance Analysis of Electrochemical Phenomena in Commercial Battery Cells.

Advancing electrochemical energy storage devices relies on versatile analytical tools capable of revealing the molecular mechanisms behind the function and degradation of battery materials in situ. The nuclear magnetic resonance phenomenon plays a pivotal role in fundamental studies of energy materials and devices because of its exceptional sensitivity to local environments and the dynamics of many electrochemically relevant elements. The jelly roll architecture is one of the most energy-dense and, therefore, most popular concepts implemented in pouch, prismatic, and cylindrical Li- and Na-ion cells. Such widely commercialized designs, however, represent a significant obstacle for a range of powerful in situ magnetic resonance-based methodologies due to negligible radio frequency electromagnetic field penetration through conductive metal casings and current collectors. In this work, we introduce an experimental setup that enables direct RF wave transmission through the cell terminals and current collectors, and provides efficient excitation and detection of NMR signals. An RF adapter designed as a plug-and-play device effectively turns the battery cell into an NMR probe that can be tuned to a broad range of Larmor frequencies. Due to its exceptional sensitivity, versatility, and multinuclear capability, the proposed methodology is suitable for fundamental research and industrial high-throughput screening applications. In situ NMR lineshapes provide a direct quantitative description of the chemical environments of electrochemically active elements and enable new metrics for the accurate assessment of state-of-charge (SoC) and state-of-health (SoH). Specifically, in commercial pouch cells based on lithium cobalt oxide, lithium nickel manganese cobalt oxide, and sodium nickel iron manganese oxide chemistries, 7Li and 23Na NMR data unambiguously show electrochemical transformations between intercalated and metallic forms of charge carrier ions, and reveal anisotropic magnetic properties of the electrode coating.

Catalytic oxidation of Mn(II) in the co-presence of Fe(II) by free chlorine: significance of in situ formed Mn(II)-doped Fe(III) oxides

Fe(II) and Mn(II) are abundant in groundwater and require operationally simple and efficient method to remove in drinking water treatment. The rapid oxidation of Mn(II) is essential in water treatment. This study investigates the efficiency of Mn(II) oxidation by free chlorine in the presence of Fe(II). The results demonstrate that the presence of Fe(II) significantly accelerates the oxidation rate of Mn(II) by free chlorine under neutral and alkaline conditions. The rapid oxidation of Fe(II) by free chlorine and the presence of Mn(II) promote the formation of in situ Mn(II)-doped ferrihydrite. Kinetic modeling and characterization of Fe(III) oxides confirm that the heterogeneous catalytic effect of the Mn(II)-doped ferrihydrite, rather than manganese oxides or their coupled catalytic effect, is responsible for the enhanced oxidation rates. The doped Mn(II) substitutes the tetrahedral Fe(III) ions in the ferrihydrite, introducing additional negative charges at the doped sites. The increased charge enhances Mn(II) adsorption and lowers its redox potential, thereby accelerating Mn(II) oxidation rate through direct electron transfer with adjacent free chlorine. Additionally, the lepidocrocite formed by the reaction between Fe(II) and dissolved oxygen significantly impedes the catalytic performance. These findings provide new insights into the catalytic co-oxidation mechanism of Fe(II) and Mn(II), and help the optimization of water treatment engineering practices.

Enhancing performance and sustainability of lithium manganese oxide cathodes with a poly(ionic liquid) binder and ionic liquid electrolyte

Current battery production involves various energy intensive processes and the use of volatile, flammable and/or toxic chemicals. This study explores the potential for using a water-soluble and functional binder, poly(diallyldimethylammonium) (PDADMA) with diethyl phosphate (DEP) as a counter anion, for lithium manganese oxide (LMO) cathodes. By replacing the traditional polyvinylidene fluoride (PVDF) binder and its associated toxic N-methyl-2-pyrrolidone (NMP) solvent, PDADMA-DEP offers a more sustainable and cost-effective solution. Notably, PDADMA-DEP electrodes do not require high-temperature calendaring to achieve high performance unlike PVDF electrodes. X-ray Photoelectron Spectroscopy (XPS) indicated significant interactions between the binder and LMO that enhance stability and ion conduction. The PDADMA-DEP binder demonstrated excellent electrochemical rate capability up to 10C with the conventional organic liquid electrolyte (LP30), outperforming PVDF electrodes. The performance of both binders using a safer and non-volatile ionic liquid electrolyte, specifically 50 mol% LiFSI in N-trimethyl-N-propylammonium bis(fluorosulfonyl)imide, was also investigated to enhance the overall safety and environmental impact of the battery system. IL-based cells utilizing a PDADMA-DEP cathode binder demonstrated a 58 % capacity retention over 500 cycles at 0.5C when cycled at room temperature.

Gradient and De-Clustered Anionic Redox Enabled Undetectable O2 Formation in 4.5V Sodium Manganese Oxide Cathodes.

Anionic redox chemistry presents a promising approach to enhancing the energy density of oxide cathode materials. However, anionic redox reactions invariably lead to O2 formation, either as free gaseous O2 or trapped molecular O2, which destabilizes the material's structure. Here, this critical challenge is addressed by constructing a crystal structure with both gradient redox activity and de-clustered redox-active oxygen. This design strategy is directly validated by operando differential electrochemical mass spectrometry and ex situ 50K electron paramagnetic resonance, revealing no release of O2 or trapped O2 in the 4.5V P2-type sodium manganese-based layered oxide. Notably, the material exhibits a highly reversible capacity of 247mAhg-1 at 20mAg-1 and exceptional capacity retention of 91.4% after 300 cycles at 300mAg-1. In situ X-ray diffraction further suggests that the absence of O2 formation suppresses the typical P2-O2 phase transition, resulting in a minimal lattice volume change of only 0.5%. Ex situ neutron diffraction studies and theoretical calculations further elucidate that the locally ordered lattice is well-preserved, attributable to reduced cationic migrations during cycling.

Tailoring of Ultrasmall NiMnO3 Nanoparticles: Optimizing Synthesis Conditions and Solvent Effects

Nickel manganese oxide (NiMnO3) combines magnetic and dielectric properties, making it a promising material for sensor and supercapacitor applications, as well as for catalytic water splitting. The efficiency of its utilization is notably influenced by particle size. In this study, we investigate the influence of thermal treatment parameters on the phase composition of products from alkali co-precipitation of nickel and manganese (II) ions and identify optimal conditions for synthesizing phase-pure nickel manganese oxide. Ultrafine nanoparticles of NiMnO3 (with sizes as small as 2 nm) are obtained via liquid-phase ultrasonic dispersion, exhibiting a narrow size distribution. A systematic exploration of the solvent nature (water, N-methyl-2-pyrrolidone, dimethyl sulfoxide, dimethylformamide) on the efficiency of ultrasonic dispersion of NiMnO3 nanoparticles is provided. It is demonstrated that particle size is influenced not only by absorbed acoustic power, dependent on the physical properties of the used solvent (boiling temperature, gas solubility, viscosity, density) but also by the chemical stability of the solvent under prolonged ultrasonic treatment. Our findings provide insights for designing ultrasonic treatment protocols for nanoparticle dispersions with tailored particle sizes.

Enhanced formaldehyde oxidation of plywood using MnO2 nanoflowers supported on porous hydrothermal carbon at ambient temperature

MnO2 nanoflowers were supported on porous hydrothermal carbon via in situ loading and used for the catalytic oxidation of formaldehyde from plywood manufactured with UF adhesive. The prepared MnO2 had a δ-type structure. The use of hydrothermal carbon (Hcs) improved the dispersion of active components in the materials and provided space for the catalytic reactions. Hcs/MnO2 exhibited catalytic activity and stability during formaldehyde oxidation at room temperature. The formaldehyde removal efficiency reached 90.43 % in 30 min. The Hcs/MnO2 had more oxygen vacancies than the MnO2 catalyst, providing more abundant active substances such as -OH, O2-, O- and other active substances to promote the catalytic reaction. The effects of Hcs/MnO2 on the formaldehyde emission and the mechanical properties of plywood were investigated. The MOR, MOE and bonding strength of the Hcs/MnO2-loaded plywood with 9 % Hcs were 51.1 MPa, 2994 MPa, and 0.8 MPa, respectively. After 28 d of exposure, the formaldehyde emitted from the plywood treated with Hcs/MnO2 decreased to 0.023 mg/m3, which fulfilled the requirement for ENF grading. The controlled release of free formaldehyde from plywood by Hcs/MnO2 was reflected by changes in mass transfer and catalytic oxidation. The manganese oxides in the micropores of the wood reduced the diffusion coefficient of free formaldehyde and hindered migration through the substrate. Once the concentration of formaldehyde decreased to a certain level, it was degraded by Hcs/MnO2, thus removing formaldehyde from the source.

Transect approach for assessing major and trace elemental contamination in agricultural soils of the palamaner division, chittoor district, andhra pradesh, india.

Three soil transects located in the granitic regions of Palamaner mandal, Andhra Pradesh, India, were examined to assess the pollution levels of both primary and secondary metals (Si, Al, Fe, Ca, Mg, Na, K, Cu, Mn, P, and Zn) and to ascertain the degree of soil pollution in agricultural areas. The soils along these transects are slightly acid to neutral, with dark brown to red rubified argillic clay-rich B horizons alongside a moderate cation exchange capacity. The A horizon soils display low organic carbon levels with a moderate variability and contain over 70% SiO2, exhibiting low variability due to limited leaching in a semiarid climate. The findings suggest that iron (Fe) and manganese (Mn) oxides play a role in reducing contamination levels through oxidation and precipitation processes. Furthermore, the soils show low to moderate cation exchange capacity, which restricts the retention of absorbed heavy metals, thus lessening their negative impacts. A two-way ANOVA revealed significant differences in CEC, organic carbon, and total zinc content across different horizons and landscape positions. Si, Al, and Cu had small increases and negative geoaccumulation indices in all soil profiles, suggesting no pollution. However, the Nemerow and mean contamination degree over 6 point to slight to moderate pollution. The analysis identified three distinct clusters with significant variations in contamination factors for SiO2 and Cu. Five principal components were determined, explaining 76% of the total variance, primarily derived from geogenic sources and remaining within acceptable limits. This research on soil transects in granitic regions contributes to a better understanding of the distribution, movement, and concentration of elemental oxides based on slope position, which is essential for pollution assessment and soil quality enhancement.

Efficient manganese ammonia oxidation (Mnammox) and its influencing factors at low temperature: Metal oxide-mediated denitrification process in water bodies

This study explores the metal oxide-mediated NH4+-N reduction process: manganese ammonia oxidation efficiency, influencing factors and its resistance to low-temperature environments in water bodies. After 177d of stabilized startup of an up-flow reactor, NH4+-N removal efficiency was 63.51 %, total nitrogen (TN) removal rate was 0.021 kg/(m3.d), and effluent Mn2+ concentration was 1.503 mg/L, which was in dynamic equilibrium. X-ray photoelectron spectroscopy exhibited manganese valence state 3.29, similar to biological manganese oxidation. High-throughput sequencing revealed that phyla’s denitrification function increased relative abundance, and manganese-reducing bacterial genera appeared. The batch test showed that 5 mg MnO2 had NH4+-N removal at 85.01 %. After 44 days, NH4+-N removal efficiency was 77.47 %, effluent Mn2+ concentration was 3.280 mg/L, TN removal rate was 0.063 kg/(m3.d). The long-term effect of the influent load change on the denitrification and Mnammox efficiency at 25 ∼ 15 °C was examined. Effluent Mn2+ concentration was 1.811 mg/L was relatively stable. Manganese valence decreased from 3.29 to 3.20, Mn4+ decreased by 9.58 %, while Mn3+ and Mn2+ increased by 10.94 % and 1.37 %, respectively. A new phylum Thermotogota and genus SBR1031 appeared in the microbial community.

Improving the Performance of the Layered Nickel Manganese Oxide Cathode of Sodium-Ion Batteries by Direct Coating with Sodium Niobium Oxide.

This research highlights the efficacy of NaNbO3 as a coating for P2-Na2/3Ni1/3Mn2/3O2 cathodes in sodium-ion batteries. The coating enhances the kinetic behavior and cyclability of the electrochemical cells, as shown by electrochemical measurements. XRD analysis indicates that Nb does not incorporate into the cathode structure, implying a physical interaction between the coating and the cathode material. XRF analysis and EDX mapping confirm the actual composition and uniform dispersion of elements throughout the sample, while the electron micrographs evidence the occurrence of NaNbO3 particles modifying the surface of the layered oxide. The Ni4+/Ni3+ and Ni3+/Ni2+ redox pairs, along with the partially reversible oxidation of oxide to peroxide anions, contribute significantly to cell capacity, as revealed by XPS spectra. This last effect and the appearance of a co-intercalated phase at high voltage are positive factors to provide fast kinetics. Cyclic voltammograms show that samples coated with 2-3% NaNbO3 have superior rate capability, with high capacitive response and apparent diffusion coefficients. These samples also have low impedance at the electrode-electrolyte interface, which helps deliver a high capacity at 5C. Further cycling at 1C shows improved cyclability in the bare and 3% coated samples, due to their higher diffusion coefficients on charging. Notably, the 3% NaNbO3-coated sample exhibits excellent cyclability below 0 °C, making it a promising cathode material for sodium-ion batteries.

Prediction of metal recovery potential of end-of-life NEV batteries in China based on GRA-BiLSTM

As Chinese new energy vehicle (NEV) sales continue to grow, end-of-life batteries have great potential for recycling in the future. In this study, a combined model based on Gray Relation Analysis and Bi-directional Long Short-Term Memory (GRA-BiLSTM) is proposed for predicting NEV sales, and the NEV battery life is modeled using the Weibull distribution. Then, the amount of end-of-life batteries, secondary utilization and metal recycling are calculated. The impact of end-of-life battery recycling on the supply and demand of key metals is studied. The results show that in 2040, the secondary utilization of end-of-life batteries in the Standard Growth Rate-Lithium Iron Phosphate Battery Dominated-High Secondary Utilization rate scenario (SGR-LFPH) is 391.76 GWh. The recycling volumes of lithium, nickel and cobalt are 45,900 tons, 92,900 tons and 22,100 tons, respectively. In the Standard Growth Rate-lithium nickel cobalt manganese oxide Battery Dominated-Low Secondary Utilization rate scenario (SGR-NCML), the recycling of lithium, nickel and cobalt is even greater, at 62,600 tons, 372,200 tons and 71,700 tons, respectively. End-of-life batteries recycling can reduce the demand for metals. However, as NEV sales continue to grow, the gap between metal supply and demand remains significant. The findings urge the Chinese government develop appropriate battery management strategies to increase the recycling rate of end-of-life batteries; and to encourage enterprises to research new types of batteries to resolve the conflict between supply and demand for metals.

Research progress of Mn-based low-temperature SCR denitrification catalysts.

Selective catalytic reduction (SCR) is a efficiently nitrogen oxides removal technology from stationary source flue gases. Catalysts are key component in the technology, but currently face problems including poor low-temperature activity, narrow temperature windows, low selectivity, and susceptibility to water passivation and sulphur dioxide poisoning. To develop high-efficiency low-temperature denitrification activity catalyst, manganese-based catalysts have become a focal point of research globally for low-temperature SCR denitrification catalysts. This article investigates the denitrification efficiency of unsupported manganese-based catalysts, exploring the influence of oxidation valence, preparation method, crystallinity, crystal form, and morphology structure. It examines the catalytic performance of binary and multicomponent unsupported manganese-based catalysts, focusing on the use of transition metals and rare earth metals to modify manganese oxide. Furthermore, the synergistic effect of supported manganese-based catalysts is studied, considering metal oxides, molecular sieves, carbon materials, and other materials (composite carriers and inorganic non-metallic minerals) as supports. The reaction mechanism of low-temperature denitrification by manganese-based catalysts and the mechanism of sulphur dioxide/water poisoning are analysed in detail, and the development of practical and efficient manganese-based catalysts is considered.

Boosting the synergistic activation of δ-MnO2 as cathode for aqueous zinc-ion batteries through Ni, Co co-doping

Layered δ-MnO2 is regarded as a promising cathode material for high-performance aqueous zinc-ion batteries (AZIBs) due to the sufficient interlayer spacing for the accommodation and migration of charge carriers. However, the sluggish activation process limits the reversible capacity, thus prevent their application. In this study, Ni-Co co-doped layered δ-MnO2 was designed to enhance ion diffusion capability and cycling stability. The influencing mechanism of Ni and Co on the long activation process are proposed by a comparative analysis between single doping and co-doping approaches. Specifically, the optimized co-doped δ-MnO2 maintained a high specific capacity of 200.2 mAh·g−1 with a capacity retention of 97.40 % after 700 cycles at 1 A·g−1. The co-doping approach exhibited a synergistic effect in suppressing Mn dissolution and enhancing ion diffusion capability. These findings provide new directions on boosting the synergistic activation process of manganese oxide and shed lights on the rational design of low-cost and high-safe batteries.

Electro‐Oxidation of Ibuprofen and Metoprolol Using a Manganese Oxide Platform

AbstractPharmaceutical compounds, such as ibuprofen and metoprolol, are of increasing concern due to their persistence in the environment and potential adverse effects on human health. In this work, we developed an electrochemical sensor system for the determination of ibuprofen and metoprolol based on a modified manganese oxide nanoparticle (MnO2NPs) on a screen‐printed carbon electrode (SPCE). The characterisation of MnO2NPs modifier was investigated via Fourier transform infrared (FTIR), X‐ray diffraction (XRD), scanning electron microscopy (SEM), Raman spectroscopy techniques, Uv/vis spectroscopy, and small‐angle X‐ray scattering spectroscopy. The electrochemical behaviour of the MnO2NPs was studied using differential pulse voltammetry (DPV) and cyclic voltammetry (CV) techniques. The optimum experimental conditions were investigated by examining the effects of scan rates, pH on the CV responses, and electrolytes on the DPV response. The MnO2NPs modified electrode demonstrated enhanced catalytic activity in the electro‐oxidation of both ibuprofen and metoprolol. The oxidation peaks of ibuprofen and metoprolol were observed at +1.14 V and +1.46 V, respectively, for the MnO2NPs/SPCE sensor. The sensor's limit of detection was 3.81 pM and 4.6 pM respectively and its linear response was from 0.97–5.82 pM. Furthermore, interference and stability studies were conducted to evaluate the performance of the MnO2NPs/SPCE sensor under optimum conditions, which resulted in a good performance. The proposed sensor was successfully used for the determination of ibuprofen and metoprolol in the application of real water samples.

Investigation on the Efficiency and Mechanism of Iron and Manganese Removal from Acid Mine Drainage Using Serpentine-Loaded Manganese Oxide

Investigation on the Efficiency and Mechanism of Iron and Manganese Removal from Acid Mine Drainage Using Serpentine-Loaded Manganese Oxide

Local Release of Copper Manganese Oxide Using HA Microneedle for Improving the Efficacy of Drug-Resistant Wound Inflammation.

The production of bacterial toxins and excessive accumulation of reactive oxygen species (ROS) can induce localized oxidative stress, triggering an exaggerated immune response that impedes wound healing and culminates in chronic wounds. To address this issue, a microneedle (MN) system loaded with copper-manganese oxide (CMO) is developed to modulate the hyperimmune response in wounds. CMO@MN exhibits excellent antimicrobial and anti-inflammatory properties by effectively killing bacteria, scavenging ROS, and modulating macrophage polarization through their multiple enzymatic activities and photothermal properties. RNA sequencing revealed that CMO@MN improved the therapeutic effect on the infected skin of mice by balancing the ratio of M1/M2 macrophages and promoting cell migration and angiogenesis through the regulation of relevant pathways. Overall, this CMO@MN patch skillfully balances the complex issues between the immune response and wound healing and has potential applications in the treatment of other serious bacterial infections.

The potential role and biological assessment of Cu doped manganese oxide nanoparticles

The potential role and biological assessment of Cu doped manganese oxide nanoparticles