With poor transportation infrastructure and increased reliance on motorization, fast-growing cities in the Global South that are experiencing rapid urbanization have received less attention in terms of sustainable transportation research. In this regard, it is imperative to support active mobility and public transit that help to reduce vehicle emissions, traffic congestion, road fatalities, and energy depletion while supporting public health, robust economies, and social equity. However, in the emerging cities context, the adoption of sustainable transportation options are constrained by various factors. This study aims to explore the key factors hindering the adoption of sustainable transportation options in Addis Ababa, Ethiopia. To do so, travel survey data were gathered from 720 households using stratified sampling and analyzed using factor analysis. The results from factor analysis indicated five groups of factors hindering residents’ intention to adopt sustainable transportation options, including (1) infrastructure condition, (2) modal characteristics, (3) land use pattern, (4) policy framework, and (5) technology-related factors. The confirmatory factor analysis also depicts the five latent factors and the contributions of observed variables that are statistically significant (p < 0.01). More specifically, observed variables such as (i) inadequate pedestrian facilities, (ii) lack of bike facilities, (iii) poor public transit facilities, (iv) limited availability of reliable public transport, (v) long wait times, (vi) high public transport fare, (vii) discomfort, (viii) safety and security issues are the most significant factors. Another set of factors includes (ix) walking distance, (x) dispersed land use pattern, (xi) poor land use mix, (xii) inadequate policy support, and (xiii) lack of real-time information. Furthermore, the intention to adopt sustainable modes of transportation is influenced by socio-demographic characteristics such as gender, age, educational status, income, family size, and car ownership. The result contributes to the existing literature by providing insight into adopting sustainable transportation modes in emerging cities like Addis Ababa, which are characterized by several urban transportation challenges.