Event Abstract Back to Event Sensorimotor interactions lateralize speech production Christian A. Kell1* and Christian Keller2 1 Goethe University, Germany 2 Brain Imaging Center, Goethe University Frankfurt, Germany Left-hemisphere dominance of speech production could be related to specialized frontal or sensory cortices. Sensory cortices are the first brain regions to lateralize in anticipation of sensory feedback (Kell et al., 2011), indicating that specialization of sensory cortices may actually drive left-lateralization of speech production. Yet, the relationship to lateralization of speech perception (Hickok & Poeppel, 2007) has remained unclear. To test the differential contributions of articulatory, sensorimotor, and speech perception systems to lateralization of speech perception and production 39 healthy right-handed participants were studied using a cue-target reading paradigm that dissociated top-down preparatory processes from stimulus-related computation. Subjects prepared either to read overtly, covertly, or to observe unutterable pseudowords or symbol strings, followed by task execution. fMRI data were standard preprocessed and preparation and execution separately analyzed in SPM8. Independent of the baseline used, lateralization during overt reading always started in sensory cortices. While covert reading revealed the bilateral ventral and left dorsal streams, preparation for overt reading involved additionally a bilateral anterior frontotemporal network. Psychophysical interactions confirmed that sensorimotor regions were under additional prefrontal control during preparation for overt reading. We additionally studied a patient who recovered from a left superior temporal lobe lesion. Despite intact left speech motor representations, motor preparation was severely affected by the lack of sensory feedback in the left: sensorimotor integration shifted to the right, suggesting a lateralized sensorimotor integration mechanism underlying lateralized speech production. Funding: Supported by German Academic Exchange Service and the Medical Faculty of Goethe University. Keywords: fMRI, Language Conference: XI International Conference on Cognitive Neuroscience (ICON XI), Palma, Mallorca, Spain, 25 Sep - 29 Sep, 2011. Presentation Type: Poster Presentation Topic: Poster Sessions: Neural Bases of Language Citation: Kell CA and Keller C (2011). Sensorimotor interactions lateralize speech production. Conference Abstract: XI International Conference on Cognitive Neuroscience (ICON XI). doi: 10.3389/conf.fnhum.2011.207.00184 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 19 Nov 2011; Published Online: 28 Nov 2011. * Correspondence: Dr. Christian A Kell, Goethe University, Frankfurt, Germany, c.kell@em.uni-frankfurt.de Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Christian A Kell Christian Keller Google Christian A Kell Christian Keller Google Scholar Christian A Kell Christian Keller PubMed Christian A Kell Christian Keller Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.