Traffic engineering such as tunnels in various altitudinal gradient zone are at risk of accidental explosion, which can damage personnel and equipment. Accurate prediction of the distribution pattern of explosive loads and shock wave propagation process in semi-enclosed structures at various altitude environment is key research focus in the fields of explosion shock and fluid dynamics. The effect of altitude on the propagation of shock waves in tunnels was investigated by conducting explosion test and numerical simulation. Based on the experimental and numerical simulation results, a prediction model for the attenuation of the peak overpressure of tunnel shock waves at different altitudes was established. The results showed that the peak overpressure decreased at the same measurement points in the tunnel entrance under the high altitude condition. In contrast, an increase in altitude accelerated the propagation speed of the shock wave in the tunnel. The average error between the peak shock wave overpressure obtained using the overpressure prediction formula and the measured test data was less than 15%, the average error between the the propagation velocity of shock waves predicted values and the test data is less than 10%. The method can effectively predict the overpressure attenuation of blast wave in tunnel at various altitudes.