Skin grafts of various sizes, shapes, and positions were transposed between back and belly of frog tadpoles at midlarval stages. The aim of the experiments was to determine the effect of size and position of the graft on the development of reflexes evoked by light mechanical stimulation of the graft. Normal reflex movements of a limb were aimed at the stimulated point, and misdirected reflexes were aimed at the original position of the grafted skin rather than at the point of stimulation. At first only normal reflexes were evoked from all types of grafts. Grafts smaller than 40 mm 2 continued to give only normal responses. After a period of normal reflexes lasting a variable number of days after metamorphosis, misdirected reflexes were elicited from a small region of larger grafts. The position of this region was in the area of overlap of reflexogenous zones of forelimbs and hindlimbs. In larger grafts, the zone giving rise to misdirected reflexes spread gradually at a rate of about 1 mm per day until it occupied almost the entire graft. In those cases, the percentage of misdirected reflexes evoked from the graft was directly proportional to the graft area. Receptive fields of cutaneous nerves were mapped electrophysiologically. It was observed that nerves supplying the large grafts did not innervate surrounding skin and vice versa, but nerves grew across the margins of small grafts. The mechanism of exclusion of surrounding nerves by large grafts is not known. We concluded that misdirected reflexes developed after transposing pieces of back and belly skin in midlarval tadpoles, only if the area of the graft exceeded 40 mm 2 after metamorphosis, and if the graft crossed the boundaries of fore- and hindlimb reflexogenous zones.