Abstract Pervasive plug-in fast chargers and/or electrified roadways (eRoads) might address the limited range, long recharging times, and reliance on greenhouse gas (GHG)-intensive, costly, and heavy batteries associated with electrifying long-haul heavy-duty trucks (HDTs). While these large-scale interventions shift environmental and cost burdens onto infrastructure, there is a lack of studies investigating how eRoads affect system-level GHG emissions, costs, material use, and peak electric grid power demands. We compare these aspects for the case of electrifying U.S long-haul HDTs (Class 8) in 2050 powered by combinations of plug-in fast chargers and eRoads. Our model accounts for battery downsizing, energy consumption, and truck operation patterns in quantifying life cycle impacts of batteries, plug-in chargers, eRoads, and hourly truck electricity demand. We find that plug-in fast chargers and eRoads reduce annualized 2050 HDT life cycle GHG emissions by 8% to 14% compared to using long-range batteries, which in turn have at least 50% lower emissions than diesel trucks. Conductive rails, overhead lines, and wireless eRoads (amortized across light- and heavy-duty vehicles) have lower system-wide costs than long-range batteries, plug-in fast chargers, or diesel trucks. Cost savings from smaller batteries, lower energy use and avoided recharging time offset high eRoads capital costs. While eRoads can reduce both system-level GHG and costs compared to diesel trucks, these reductions are sensitive to eRoads capital costs and losses from wireless power transfer and air resistance. eRoads require less lithium (87%) and copper (67%) than long-range batteries but increase regional peak power demands by up to 32%. Efficient wireless power transfer and aerodynamic pantographs enhance eRoads’ GHG and cost advantages, which may diminish if future batteries are more energy-dense, cheaper, or less GHG intensive. If successfully deployed, eRoads present opportunities for tighter integration between the transportation and electricity infrastructure systems, enabling optimized charging strategies to lower GHG emissions and costs.