Letters4 February 2014Screening for Lung Cancer With Low-Dose Computed TomographyLinda L. Humphrey, MD, MPH, Mark Deffebach, MD, Miranda Pappas, MA, Bernadette Zakher, MBBS, and Christopher G. Slatore, MD, MSLinda L. Humphrey, MD, MPHFrom Portland Veterans Affairs Medical Center, Portland, Oregon; Oregon Health & Science University, Portland, Oregon; and Portland Veterans Affairs Medical Center, Portland, Oregon.Search for more papers by this author, Mark Deffebach, MDFrom Portland Veterans Affairs Medical Center, Portland, Oregon; Oregon Health & Science University, Portland, Oregon; and Portland Veterans Affairs Medical Center, Portland, Oregon.Search for more papers by this author, Miranda Pappas, MAFrom Portland Veterans Affairs Medical Center, Portland, Oregon; Oregon Health & Science University, Portland, Oregon; and Portland Veterans Affairs Medical Center, Portland, Oregon.Search for more papers by this author, Bernadette Zakher, MBBSFrom Portland Veterans Affairs Medical Center, Portland, Oregon; Oregon Health & Science University, Portland, Oregon; and Portland Veterans Affairs Medical Center, Portland, Oregon.Search for more papers by this author, and Christopher G. Slatore, MD, MSFrom Portland Veterans Affairs Medical Center, Portland, Oregon; Oregon Health & Science University, Portland, Oregon; and Portland Veterans Affairs Medical Center, Portland, Oregon.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/L14-5003-3 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:As we noted in our article and the associated systematic review, overdiagnosis is a risk of lung cancer screening of uncertain magnitude. We do not believe that the Mayo Lung Project provides a valid estimate of overdiagnosis for many reasons, most of which we outlined in our report (1) and the prior review (2). More research in this important area is needed.We rated the quality of the DLCST as moderate. Limitations that we identified included a lack of description of allocation concealment, as Drs. Brodersen, Dirksen, and Pedersen note. They state that patients were randomly assigned at ...