Overall Prevalence Of Osteoporosis Research Articles

Evaluation of osteoporosis among medical and paramedical staffs in a tertiary health-care hospital in India

Background: Osteoporosis is a silent, underdiagnosed disease, which is characterized by low bone mass leading to increased susceptibility to fractures. Screening for osteoporosis is not routinely done despite growing awareness of this condition and its complications. Routine screening practices can help early detection and treatment. Materials and Methods: The objective of this study was to measure the bone mineral density (BMD) of health-care professionals (doctors and nurses) using calcaneal ultrasound heel bone densitometer. This was a cross-sectional study conducted in a tertiary care hospital involving 863 individuals. BMD was measured using calcaneal quantitative ultrasonography and T-scores were calculated. Results: The overall prevalence of osteoporosis and osteopenia among men and women was similar in our study. Nearly 50% of staff nurses were found to be below normal as per T-scores. Among doctors, contrasting popular belief, the prevalence of osteoporosis was higher in males than in females. Conclusion: This study indicates that medical professionals are equally at risk of osteoporosis as the normal population and should be targeted for routine screening and preventive interventions to curtail osteoporosis and its complications.

OFELIA: Prevalence of Osteoporosis in Fragility Fracture Patients.

Worldwide, a care gap has been recognized between presenting with a fracture and prevention of the next fracture. Fracture Liaison Service is the most cost-effective method to close this gap, but its implementation is sparse in the Nordic countries. To assess the need for a fracture prevention program, the primary aim of this study was to estimate the prevalence of osteoporosis in patients treated for fragility fractures at Aarhus University Hospital, Denmark. Secondary aims were to identify clinical risk factors associated with osteoporosis and the up-take of anti-osteoporosis treatment. The study was conducted as a cross-sectional study and patients aged 18+ years were consecutively identified over a 12months period. Of 1164 identified patients, 832 were included and 794 (70% women, 66% aged ≥ 50years) patients completed the study. Bone mineral density was measured by DXA and information about clinical risk factors were obtained. The overall prevalence of osteoporosis in this cohort was 14.9%, increasing to 20.3% in patients ≥ 50years (22.9% in women, 9.6% in men). In addition to age above 50years, female sex, low BMI, and early menopause were significantly associated with osteoporosis. At 3-years follow-up in patients diagnosed with osteoporosis, 95% of patients who initiated anti-osteoporosis treatment after their fracture were still adherent to treatment. Given that osteoporosis was demonstrated in one in five fragility fracture patients above 50years, OFELIA stresses the need for implementation of a program aiming at securing appropriate investigation and treatment of osteoporosis in patients presenting a fragility fracture.

Osteoporosis in Chronic obstructive Pulmonary Disease (COPD) Patients

Background: Osteoporosis is one of the most common systemic features of Chronic obstructive pulmonary disease (COPD). But there had been no data regarding osteoporosis in COPD patients in Bangladesh. Objectives: To determine the frequency of osteoporosis in COPD patients.Materials & Methods: This was a cross sectional observational study. COPD patients were recruited from Sarkari kormachari hospital. Patients were excluded if they had asthma, any disease affecting bones and calcium homeostasis or were receiving drugs related to bone metabolism. Demographic data were collected including age, smoking history, inhaled corticosteroid use, body mass index, treatment history hospital admission. Chest x-ray was done to exclude any infection or malignancy. Blood was obtained for complete blood count, renal function test, CRP. Bone mineral density (BMD; g/cm2) was conducted by using dual energy x-ray absorptiometry scan (DXA scan) at second to fourth lumbar spines (L2-4) and femoral neck.Results: The overall prevalence of osteoporosis according to the lowest T-score at either L2-4 or femoral neck were 56.7%. This is very high than other country. BMI and CRP were significantly associated with osteoporosis.Conclusion: The frequency of osteoporosis in Bangladeshi COPD patients was higher than others. Osteoporosis was associated with low BMI and high level of CRP.J MEDICINE JUL 2018; 19 (2) : 114-118

Investigation and analysis of osteoporosis, falls, and fragility fractures in elderly people in the Beijing area: a study on the bone health status of elderly people ≥ 80years old with life self-care.

The purpose of this study is to investigate prevalence of osteoporosis, falls, and fragility fractures in this population, and analyze related factors, in order to provide a basis for standardized prevention and treatment. From August 2015 to August 2016 in Beijing City, a total of 175 elderly individuals, who were ≥ 80years old and had good self-care ability, were included into this study. The questionnaire, risk of falls, grip force, and walking speed were measured, and the Timed Up and Go test (TUG) and chair-rising test (CRT) were performed. Compared to women, men have higher rates of smoking, drinking, drinking strong tea, longer outdoor activity time, as well as larger muscle strength and pace, and lower consumption of dairy products, fall risk assessment scale (FRA) score, 25OHD, administration rates of calcium and anti-osteoporosis drugs (P < 0.05, P < 0.01). Compared with men, women had higher bone turnover markers (P1NP, β-CTx, and OC) (P < 0.05, P < 0.01) and lower levels of sex hormones (E2, T) (P < 0.01). The overall prevalence of osteoporosis was 24.6%, and this was significantly higher in women than in men (52.5 vs. 9.6%, P < 0.01). Among these subjects, 62.9% had a history of fall after 80years old, and this rate was higher in women than in men (77 vs. 55.3%, P < 0.01). The overall prevalence of fragility fractures was 25.1%, which was higher in women than in men (45.9 vs. 14.0%, P < 0.01). Risk factors included falls after age 80, high FRA score, and reduction in bone density of lumbar vertebrae 1-4, and odds ratio (OR) was 12.195, 1.339, and 0.076, respectively (P < 0.01). Anti-osteoporosis therapy was only performed on a small number of patients with fractures. The prevalences of falls, prior fracture, and low BMD were high among ≥ 80years old and under life self-care in the Beijing area. Therefore, a comprehensive approach to assessment and treatment should be promoted.

Prevalence of Osteoporosis and Low Bone Mass Among Puerto Rican Older Adults.

Historically, osteoporosis has not been considered a public health priority for the Hispanic population. However, recent data indicate that Mexican Americans are at increased risk for this chronic condition. Although it is well established that there is heterogeneity in social, lifestyle, and health-related factors among Hispanic subgroups, there are currently few studies on bone health among Hispanic subgroups other than Mexican Americans. The current study aimed to determine the prevalence of osteoporosis and low bone mass (LBM) among 953 Puerto Rican adults, aged 47 to 79 years and living on the US mainland, using data from one of the largest cohorts on bone health in this population: The Boston Puerto Rican Osteoporosis Study (BPROS). Participants completed an interview to assess demographic and lifestyle characteristics and bone mineral density measures. To facilitate comparisons with national data, we calculated age-adjusted estimates for osteoporosis and LBM for Mexican American, non-Hispanic white, and non-Hispanic black adults, aged ≥50 years, from the National Health and Nutrition Examination Survey (NHANES). The overall prevalence of osteoporosis and LBM were 10.5% and 43.3% for participants in the BPROS, respectively. For men, the highest prevalence of osteoporosis was among those aged 50 to 59 years (11%) and lowest for men ≥70 years (3.7%). The age-adjusted prevalence of osteoporosis for Puerto Rican men was 8.6%, compared with 2.3% for non-Hispanic white, and 3.9% for Mexican American men. There were no statistically significant differences between age-adjusted estimates for Puerto Rican women (10.7%), non-Hispanic white women (10.1%), or Mexican American women (16%). There is a need to understand specific factors contributing to osteoporosis in Puerto Rican adults, particularly younger men. This will provide important information to guide the development of culturally and linguistically tailored interventions to improve bone health in this understudied and high-risk population. © 2017 American Society for Bone and Mineral Research.

Prevalence and Risk Factors of Osteoporosis Among Jordanian Postmenopausal Women Attending the National Center for Diabetes, Endocrinology and Genetics in Jordan.

To assess the prevalence of osteoporosis and osteopenia among Jordanian postmenopausal women attending the National Center for Diabetes, Endocrinology, and Genetics (NCDEG), and to determine the potential associated risk factors. A cross-sectional study was conducted at (NCDEG) in Amman, Jordan. A total of 1079 Jordanian postmenopausal women aged between 45 and 84 years were included in this study that was conducted during the period between April 2013 and December 2014. All patients underwent bone mineral density measurement through dual-energy X-ray absorptiometry (DEXA) scan. DEXA scan was interpreted in terms of T score as per World Health Organization guidelines. The overall prevalence of osteoporosis and osteopenia was 37.5% and 44.6%, respectively. The maximum prevalence of osteoporosis was observed at the lumbar spine (32.4%) followed by the left femoral neck (14.4%), while the maximum prevalence of osteopenia was observed at the left femoral neck (56.1%) followed by the lumbar spine (41.3%). Patients with longer menopausal duration, normal or overweight body mass index, high parity, physical inactivity, positive family history of osteoporosis, inadequate sun exposure, high daily caffeine intake, low daily calcium intake, and delay in the age of menarche were all positively associated with osteoporosis. On the other hand, women with type 2 diabetes mellitus had lower risk of osteoporosis. There is a high prevalence of osteoporosis and osteopenia among Jordanian postmenopausal women. Necessary steps are needed for more public education and a wider dissemination of information about osteoporosis and its prevention.

Screening of osteoporosis using calcaneal quantitative ultrasound in a rural population of Jammu, Jammu and Kashmir, India

Background: Osteoporosis is a major public health problem, associated with substantial morbidity and socio-economic burden. The objective of the present study was to screen the general population for osteoporosis in a rural area of Jammu region. Methods: 3 screening camps were conducted at 6 monthly intervals between the time period 2015-2016, at the Accidental Hospital, Chowki Choura, which is a rural area of district Jammu, J&amp;K. A total of 270 subjects in the age group 20 to 80 years were subjected to screening through BMD measurements using calcaneal QUS and they were analyzed on the basis of T-scores. Results: Out of 270 subjects, 120 were males and 150 were females. Among 120 males, 68 were in the age group of 20 - 49 years, and 52 were above 50 years. In the age group 20-49 years, 26 males (38.2%) had osteopenia, and 4 (5.9%) had osteoporosis. In males above 50 years of age, 35 (67.3%) had osteopenia and 6 (11.5%) had osteoporosis. Out of 150 females, 94 were in the age groups 20-49 years, and 56 were above 50 years of age. In the age group 20-49 years, 51 females (54.3%) had osteopenia and 12 (12.8%) had osteoporosis. In females above 50 years of age, 32 (57.1%) had osteopenia and 15 (26.8%) had osteoporosis. Conclusions: The overall prevalence of osteoporosis among screened population was 13.7%. It increased with age in both males and females; however the prevalence of osteoporosis was more among females as compared to males (18% vs. 8.3% respectively).

Effects of Age and Body Mass Index on Thoracolumbar Spine X-Ray for Diagnosing Osteoporosis in Elderly Women: Tianliao Old People (TOP) Study 07.

PurposeThe aim of this study was to determine the effects of diagnostic discordance with or without a thoracolumbar spine lateral view X-ray in patients with osteoporosis.MethodsWe randomly enrolled 368 women over 65 years old (74.3 ± 6.0 years) from Tianliao Township in 2009 (response rate: 75.7%). A diagnosis of osteoporosis was confirmed using one of these criteria: (1) a history of non-traumatic fracture, (2) vertebral fractures based on a thoracolumbar spine lateral view X-ray, or (3) a bone mineral density T-score ≤ -2.5 for the total hip, the femoral neck, the lumbar spine, or all 3 sites. The prevalence of osteoporosis in three groups was compared based on Model I (criteria 1+2) vs. Model II (criteria 1+3) vs. Model III (criteria 1+2+3). The role of thoracolumbar X-ray reflected by the diagnostic discordance of osteoporosis between Models II and III was evaluated.ResultsThe overall prevalence of osteoporosis was 78.3% (Model III, age-standardized 78.1%). The diagnostic discordance was 17.4% in the 368 participants. A logistic regression model showed that age was negatively associated with diagnostic discordance (odds ratio [OR] = 0.93, 95% confidence interval [CI]: 0.88–0.98, p < 0.05), but body mass index was positively associated (OR = 1.07, 95% CI: 1.00–1.15, p < 0.05).ConclusionsA thoracolumbar spine lateral view X-ray should be added for women ≥ 65 years old or with a body mass index ≥ 25 kg/m2 to minimize the diagnostic discordance in osteoporosis, especially in highly endemic regions.

Low bone mineral density and associated risk factors in HIV-infected patients.

Aging of persons with human immunodeficiency virus (HIV) resulted in high rates of osteopenia and osteoporosis. Multiple cohort studies have reported an increased prevalence of bone demineralization among HIV-infected individuals. The aim of this study was to evaluate bone mineral density (BMD) and risk factors for osteopenia/osteoporosis among HIV-positive patients attending the National Institute for Infectious Diseases "Prof.Dr. Matei Balș", Bucharest, Romania. We performed a cross-sectional study that enrolled 60 patients with HIV. The association between BMD and lifestyle habits (smoking), body mass index (BMI), nadir cluster of differentiation 4 (CD4) cell count, current CD4 cell count, HIV viral load and history of combination antiretroviral therapy (cART) were investigated. The BMD was measured at the lumbar spine, hips and total body using dual-energy X-ray absorptiometry (DEXA). In the present study, DEXA evaluation showed an overall prevalence of osteoporosis of 16.66% (ten patients) and a prevalence of osteopenia of 48.33% (29 patients). In men, low BMI and cigarette smoking showed significant association with the diagnosis of lumbar spine demineralization (p=0.034 and p=0.041, respectively). Duration of exposure to cART classes in relation to BMD was also evaluated. The use of non-nucleoside reverse-transcriptase inhibitors (NNRTIs) was associated with low lumbar spine BMD in all patients (p=0.015). Reduced BMD was significantly associated with protease inhibitors (PIs)-containing treatment (p=0.043) in women. At lumbar spine DEXA, male gender was statistically associated with reduced BMD. At the left hip Ward's area, decreased BMD T scores were significantly associated with aging. The reduced BMD was higher in patients receiving PI- or NNRTI-containing regimens.

Decreased Bone Mineral Density in Patients Submitted to Kidney Transplantation Is Related to Age, Body Mass Index, Time on Dialysis, and Hyperparathyroidism

Background. Renal transplantation (Tx) influences bone mineral density (BMD) by several mechanisms. The main objective of this study was to correlate BMD and risk factors associated with bone loss in patients submitted to kidney Tx. Methods. We evaluated 88 individuals after renal Tx (median time = 31.5 months since Tx). All of them sustained glomerular filtration rate ≥60 mL/min/1.73 m2. BMD was measured by dual-energy X-ray absorptiometry (DXA, Prodigy-GE). Calcium, phosphate, albumin, creatinine, and intact parathormone (PTH) were measured at the same time. All statistical tests were two-sided and P value less than 0.05 were accepted as significant for all analyses in this study. Results. Serum PTH was raised in 42% patients, but corrected calcium was normal in 83 patients. No fragility fracture was reported, but the overall prevalence of osteoporosis was 27.6% and lower than expected BMD (Z-score ≤ −2.0 SD) was observed in 28.4%. Patients with lower than expected BMD had higher PTH levels. Conclusions. Older age, lower body mass index (BMI), longer time on dialysis, and elevated PTH levels were identified as the main factors associated with lower BMD.

New reference data on bone mineral density and the prevalence of osteoporosis in Korean adults aged 50 years or older: the Korea National Health and Nutrition Examination Survey 2008-2010.

This cross-sectional study was performed to investigate the reference values for bone mineral density (BMD) measured by dual-energy X-ray absorptiometry (DXA) and the prevalence of osteoporosis in the Korean population by applying domestic reference data. In total, 25,043 Korean adults ≥20 yr of age (11,792 men and 13,251 women) participated in the study. The BMDs of the total hip, femoral neck, and lumbar spine were measured by DXA (Discovery-W, Hologic Inc.), and subjects with a BMD - 2.5 standard deviations or lower than the mean BMD for young adults (20-29 yr old) were considered to have osteoporosis. When applying the new reference values determined in this study from Korean subjects, the overall prevalence of osteoporosis increased in men aged ≥50 yr compared with that provided by the DXA manufacturer from Japanese subjects (12.2% vs. 7.8%, P<0.001) and decreased in postmenopausal women aged ≥50 yr (32.9% vs. 38.7%, P<0.001). According to the findings of this study, use of the reference values provided by the DXA manufacturer has resulted in the underdiagnosis of osteoporosis in Korean men and the overdiagnosis of osteoporosis in Korean women. Our data will serve as valuable reference standards for the diagnosis and management for osteoporosis in the Korean population.

To Determine the Risk Factors and Prevalence of Osteoporosis among Adult Pakistani Population Residing in Karachi Using Quantitative Ultrasound Technique

our country too. The purpose of our study was to determine the prevalence of osteoporosis, and also to establish the risk factors associated with it in Pakistan. Method: It was a cross sectional study that was conducted in the primary care setting in different areas of Karachi. Bone mineral density assessment was done by the speed of sound using the quantitative ultrasound technique at the right Calcaneus. A structured questionnaire was prepared, to evaluate the risk factors associated with osteoporosis Results: Out of 500 participants 21.6% were male and 78.4% were female. The overall prevalence of osteoporosis was 30.7% (24% male and 32.6% females). The prevalence of osteopenia was 44.5% (51% being male and 42.6% being female). Factors that were statistically (p value <0.05) associated with low bone mineral density were increasing age, female gender for osteoporosis, normal to heavy weight, office work in both male and female, inadequate physical activity, inadequate sun exposure, inadequate intake of calcium, smoking in males and smokeless tobacco in both male and female, intake of steroids. Past history of fracture among the participants and the history of fracture in the parents, diabetes and depression also showed positive association, balanced diet and educational status and hypertension could not provide any significant statistical association with low bone mineral density. Conclusion: The prevalence of osteoporosis is high among the adult population of Karachi and it is associated with modifiable risk factors. Non-communicable diseases like, diabetes and depression, also gave a positive association, which needs further prospective studies to confirm this association.

Change in Bone Mineral Density in Post Menopausal Women with Rheumatoid Arthritis

Introduction: Low bone mass is a serious complication of post menopausal women with rheumatoid arthritis. We determined the Change in Bone Mineral Density in postmenopausal women with rheumatoid arthritis. Methods: This retrospective cohort study was carried out on consecutive postmenopausal women with rheumatoid arthritis who were referred to the Azar 5th teaching hospital affiliated to Golestan University of Medical Sciences, North of Iran in 2009. The required data were gathered from the patients’ medical records. The data were analyzed using SPSS software and statistical tests. Results: We studied 98 postmenopausal women with rheumatoid arthritis. Mean number of years since menopause and mean duration of disease were 9.39 and 5.13 respectively. T Score mean in femoral neck and lumbar spines was -1.45±1.26 and -2.45±1.44 respectively. The overall prevalence of osteoporosis at both the lumbar spine and femoral neck was 13.3. We have found a significant correlation between age, duration of disease, duration of menopause and bone mineral density (P-Value&lt;0.01). Conlusion: Our results indicate a negative effect of age, number of years since menopause and duration of disease on bone mineral density. So, BMD should be measured in high risk women prior to the implementation of any treatment or prevention program. Bangladesh Journal of Medical Science Vol. 12 No. 02 April’13 Page 158-163 DOI: http://dx.doi.org/10.3329/bjms.v12i2.14944

Evaluation of ERα and VDR gene polymorphisms in relation to bone mineral density in Turkish postmenopausal women

It has been suggested that the estrogen receptor alpha (ERα) and vitamin D receptor (VDR) genes as possibly implicated in reduced bone mineral density (BMD) in osteoporosis. The present study investigated the relation of ERα PvuII/XbaI polymorphisms and VDR FokI/TaqI polymorphisms with BMD in Turkish postmenopausal women. Eighty-one osteoporotic and 122 osteopenic postmenopausal women were recruited. For detection of the polymorphisms, polymerase chain reaction-restriction fragment lenght polymorphism techniques have been used. BMD was measured at the lumbar spine and hip by dual-energy X-ray absorptiometry. Distributions of ERα (PvuII dbSNP: rs2234693, XbaI dbSNP: rs9340799) and VDR genotypes (FokI dbSNP rs10735810, TaqI dbSNP: rs731236) were similar in study population. Although overall prevalence of osteoporosis had no association with these genotypes, the prevalence of decreased femoral neck BMD values were higher in the subjects with ERα PvuII "PP" and ERα XbaI "XX" genotypes than in those with "Pp/pp" genotypes and "xx" genotype, respectively (P < 0.05). Furthermore, subjects with VDR FokI "FF" genotype had lower BMD values of femoral neck and total hip compared to those with "Ff" genotype (P < 0.05). In the logistic regression analysis, we confirmed the presence of relationships between the VDR FokI "FF" genotypes, BMI ≤ 27.5, age ≥ 55 and the increased risk of femoral neck BMD below 0.8 value in postmenopausal women. The present data suggests that the ERα PvuII/XbaI and VDR FokI polymorphisms may contribute to the determination of bone mineral density in Turkish postmenopausal women.

Bone fragility in postmenopausal women: a preliminary study

The aim of this work is to identify the prevalence of risks factors for bone fragility in postmenopausal women with hormonal replacement therapy (HRT) within two groups (with bone fracture history and without bone fracture history) and to evaluate the effect of modifiable risk factors on bone mineral density (BMD). The overall prevalence of osteoporosis in postmenopausal Portuguese women is high. A pattern identification of occurrences, in a group of patients submitted to this analysis, will enable the formulation of conclusions for knowledge improving of these different pathologies. This preliminary study will demonstrate that age, physical exercise and coffee consumption are associated with lower BMD and osteoporosis status in postmenopausal Portuguese woman.

Clinical relation between BPPV and osteoporosis

This study was designed to investigate bone mineral density in patients with idiopathic BPPV to determine whether there is a clinical association between etiologically unknown (idiopathic) BPPV and osteoporosis. Dual energy X-ray absorptiometry was used to measure the bone mineral density (BMD) at lumbar vertebrae L2L4 in menopausal women over the age of 50 years who had been diagnosed as having idiopathic BPPV. A BMD value of less than 70% of the young adult mean (YAM) was regarded as indicating the presence of osteoporosis. The overall prevalence of osteoporosis in patients with BPPV was 27.5%, which was almost the same as that in a previously reported national survey. However, the rate of concurrent osteoporosis was higher among patients with recurrent BPPV (38.9%) than among those with non-recurrent BPPV (21.2%). Subjects with recurrent BPPV had a lower BMD (72.4% of the YAM) than those with non-recurrent BPPV. Subjects with multiple occurrences had an even lower BMD (69.4% of the YAM) and were classified as having osteoporosis. Thus, BPPV and osteoporosis may have similar pathogenetic mechanisms associated with calcium metabolism in both otoconia and bone. These results suggest that idiopathic BPPV with osteoporosis may be capable of recurring.

Osteoporosis prevalence and fracture characteristics in elderly female patients with fractures

The aim of this study was to characterize the features of fractures that occur in female patients with osteoporosis in the setting of a typical trauma hospital. Observational study was conducted on 233 women aged 50 years and above reporting to a trauma center with a fracture. Fracture location, fracture classification and cause of fracture were obtained and compared with bone mineral status assessed by DXA at the spine. Our findings indicate that with increasing patient age, the majority of fractures occur after a minor traumatic event. In more than one-third of all fractures after minor trauma, the patients were diagnosed with osteoporosis. The overall prevalence of osteoporosis in patients older than 50 years with fractures was more than 30% and was increasing with age. Most strikingly, one-third of the patients have had a previous fracture at a location that should have triggered the assessment of bone health status, but only 25% of them had received any form of osteoporosis treatment. For patients older than 50 years reporting to a trauma unit with a fracture, osteoporosis has a considerable prevalence. The large number of patients who have had a previous fracture emphasizes the necessity for an effective implementation of treatment algorithms for elderly patients with osteoporosis in the setting of a trauma hospital.

OSTEOPOROSIS

Objectives: To Study the prevalence of osteoporosis among post menopausal women in the Faisalabad city and comparethat with other developed and developing countries. S t u d y Design: A Cross Sectional Study. Place and Duration of Study: Medina TeachingHospital Faisalabad and Al Bari Hospital Faisalabad from February 2008 to April 2008. Patients and Methods: A total of 300 post menopausalwomen were included after valid consent and observing inclusion and exclusion criteria. Quantitative Ultrasound Device (QUO) that is BMDwas assessed from the heel of each participant. T-Scores were obtained and WHO classification was followed. A scale was used to assessthe Body Mass Index measuring height and weight. Data collection sheet having structured questions was used for checklist for obtainingpertinent information. Results: Out of 300 post menopausal women overall prevalence of Osteoporosis (OP) was 20%. Further, 44% wereOsteopenic. Results were comparable with other countries as well. Conclusion: Osteoporosis (OP) is not uncommon in our country. It shouldbe considered as a Public Health Problem. Early screening and prompt treatment can prevent the heavy cost on fracture managements. InPakistan, even in Asia Key data is not available to convince Policy makers that OP is a serious burden on population and to invest in preventionis the better option. Health Education is imperative for target population.

Osteoporosis in China

Based on related studies published between 1980 and May 2008, we examine the prevalence of osteoporoses in mainland China, Hong Kong, and Taiwan. Overall, the prevalence of osteoporosis among these Chinese populations remains low compared to other Caucasian populations; in the mainland, it was approximately 13%. Osteoporosis is a significant public health problem and has received great attention in industrialized countries. However, limited is known in many developing countries including China, where aging and changing lifestyles likely contribute to increased osteoporosis. The objectives of the study is to examine the disease burden (prevalence) and time trends of osteoporosis in mainland China, Hong Kong, and Taiwan. Related studies published in English and Chinese between January 1980 and May 2008 were reviewed and analyzed. The prevalence increased with age and varied dramatically based on local versus international diagnosis criteria. In the mainland, reported overall prevalence of osteoporosis based on nationwide surveys ranged from 6.6% to 19.3% (average = 13.0%). The prevalence varied considerably across studies, and by regions, gender, and bone sites, but the urban to rural difference was small. In Hong Kong, the prevalence among women > or =50 years ranged from 34.1-37% in the spine; was 7% in the same aged men. In Taiwan, among those aged > or =50 years, average prevalence of osteoporosis was 11.4% in women and 1.6% in men. Future national programs need to monitor the burden of osteoporosis in China though available data indicate that the prevalence of osteoporosis remains low compared to that of other Caucasian populations.

S1114 IBD Patients Maintained On Azathioprine Have Similar Bone Mineral Density to Patients Maintained On Infliximab with a Low Overall Prevalence of Osteoporosis

S1114 IBD Patients Maintained On Azathioprine Have Similar Bone Mineral Density to Patients Maintained On Infliximab with a Low Overall Prevalence of Osteoporosis