Ovarian Mixed Germ Cell Tumor Research Articles

Analysis of ovarian teratomas for isochromosome 12p: evidence supporting a dual histogenetic pathway for teratomatous elements

Teratomas are the most common germ cell tumor (GCT) of the ovary and include several types with a range of clinical behavior. As in testicular teratomas, they may be benign, malignant or a component of a mixed GCT. In the testis, data support separate pathogeneses for prepubertal and postpubertal teratomas, with derivation of the former from a nontransformed germ cell and the latter from differentiation of a nonteratomatous, malignant GCT. The absence of cytogenetic abnormalities (including isochromosome 12p (i(12p)) in mature ovarian teratomas suggests that they may be analogous to prepubertal testicular teratomas, but there are no data regarding genetic changes in the teratomatous components of ovarian mixed GCTs. We therefore studied the teratomatous components of six mixed GCTs of the ovary using fluorescence in situ hybridization (FISH) for i(12p). Six mixed GCTs of the ovary occurred in patients 4–33 years of age; all had teratomatous and yolk sac tumor components and three also contained foci of embryonal carcinoma. Using FISH with 12p telomeric and 12 centromeric probes, five of six (83%) cases had detectable i(12p) in their nonteratomatous components, and four of six (66%) in the teratomatous component. One of the two cases without demonstrable i(12p) in the teratomatous portion of the mixed GCT also did not have identifiable 12p abnormalities in other elements of the mixed GCT. By comparison, five pure, mature ovarian teratomas and three pure, immature ovarian teratomas showed no evidence of either i(12p) or other forms of 12p amplification. These findings support that teratoma in mixed ovarian GCTs has a different pathogenesis compared to pure teratoma of the ovary. Furthermore, the findings of i(12p) in both the teratomatous and nonteratomatous components of ovarian mixed GCTs supports that the teratoma derives from other components, similar to the situation in the testis.

Unusual location of ovarian mixed germ cell tumor

Unusual location of ovarian mixed germ cell tumor

Unusual location of ovarian mixed germ cell tumor

Intra-abdominal unusual location of mixed germ cell tumor of ovary, which consisted of endodermal sinus tumor and immature teratoma components, has been reported. Patient was a 21-year-old girl with a chief complaint of abdominal pain and mass. Ultrasound and computed tomography scan showed lobulated cystic mass. Laparotomy was performed, and due to specific localization, in which tumor localized as a tumoral bridge between two ovaries, we just performed maximal fertility-sparing surgery by preserving ovaries, tubes, and uterus. After that, four courses of chemotherapy (bleomycin, etoposide, and cis-platinum) were done to cure her. The alfa-fetoprotein became negative after three courses of chemotherapy, and she is under observation for the time being.

A case of Ovarian Mixed Germ cell tumor with rapid relapse

A case of Ovarian Mixed Germ cell tumor with rapid relapse

Systemic mast cell disease associated with primary ovarian mixed malignant germ cell tumor

A 12-year-old girl with a mixed malignant germ cell tumor of the ovary, treated by surgery and chemotherapy, developed systemic mast cell disease (SMCD) approximately 3 months after chemotherapy. Hematologic malignancies have previously been noted in patients with mediastinal germ cell tumors but this is the first report of a primary ovarian germ cell neoplasm associated with SMCD.

Ovarian Mixed Germ Cell Tumor Composed of Polyembryoma and Immature Teratoma

We report the case of a 41-year-old woman with ovarian mixed germ cell tumor which was composed of polyembryoma and immature teratoma and who had high serum levels of α-fetoprotein (AFP) and human chorionic gonadotropin (hCG). By immunohistochemical methods, AFP was found in yolk sac cells of the embryoid bodies and immature hepatoid tissues, and hCG was found in giant syncytiotrophoblastic cells. She was treated with surgery followed by cisplatin-based combination chemotherapy. She is well, and her serum levels of AFP and hCG have not been elevated for more than 4 years after the treatment.

Retroperitoneal Giant Tumor Formed by Migrating Polyembryoma with Numerous Embryoid Bodies from an Ovarian Mixed Germ Cell Tumor

We report on a very rare case of retroperitoneal tumor formed by migrating polyembryoma with numerous embryoid bodies from an ovarian mixed germ cell tumor. It was successfully removed combined with artificial replacement of the aorta following chemotherapy. We also discussed the fate of embryoid bodies following metastasis or chemotherapy.

Radiotherapy in the treatment of ovarian dysgerminomas

Between 1969 and 1983 a total of 14 patients with ovarian dysgerminoma were treated at the Institute of Oncology and Radiotherapy, the Prince of Wales Hospital, Randwick. The case records of these patients have been reviewed for presenting symptoms, treatment given, and survival following treatment. Excluded from analysis are patients with mixed ovarian germ cell tumors (dysgerminoma and teratoma). Data includes three patients referred with recurrent or residual tumor after primary surgery. Ten patients remain alive (72%). All four patients who died had recurrent intra-abdominal tumor, with or without distant metastases at the time of death. Median duration of follow-up of living patients was 54 months. Survival of those dead ranged from 8 to 168 months following treatment. The place of radiotherapy in treatment is discussed.