Ovarian Burkitt's Lymphoma Research Articles

Bilateral Ovarian Burkitt Lymphoma in a Female Adolescent, Case Report

Bilateral Ovarian Burkitt Lymphoma in a Female Adolescent, Case Report

Ovarian Burkitt lymphoma: A rare yet clinically significant entity

Primary ovarian lymphomas are rare tumors presenting as an ovarian mass that can mimic an epithelial ovarian tumor. The average age of onset is 40 years. Burkitt lymphomas, sporadic in the Western world, typically present with abdominal involvement. Biological tests and imaging guide the diagnosis. Prognosis depends on associated bone marrow and central nervous system involvement. Treatment relies on polychemotherapy. Here, we report a case of Burkitt's lymphoma in a young woman simulating advanced bilateral ovarian cancer.

Primary Ovarian Lymphoma in Late Pregnancy: A Case Report

Involvement of the ovary with malignant lymphoma is a well-known late manifestation of disseminated nodal disease. Primary ovarian Burkitt lymphoma is very rare and mainly affects young children. We present a case of a 25-year old woman at 37 weeks pregnant with sporadic Burkitt lymphoma who presented as having ovarian cancer. The patient was managed via elective cesarean section and unilateral oophorectomy. Histopathological examination and immunohistochemical stains were carried out, revealing non-Hodgkin B-cell Burkitt lymphoma. After the diagnosis, the patient was referred to the oncology center for chemotherapy.

Molecular characterization of Burkitt lymphoma in the breast or ovary

Breast and ovary have been described as rare but typical sites of presentation of Burkitt lymphoma (BL) in females, particularly after puberty. We revised a historic series of 44 lymphomas of the breast or the ovary in women diagnosed between 1973 and 2014 as BL. Fluorescence in situ hybridization (FISH) was applied to all, and array-based copy number analysis as well as expression profiling to a subset of those cases. Of the 42 cases evaluable for FISH, 19 cases showed an IG-MYC translocation but only 9 of those fulfilled the criteria of the current WHO classification for the diagnosis of BL. Those nine cases resembled BL of other sites with regard to molecular features. Our findings along with literature data suggest that breast and ovarian BL (1) seem to be rarer than hitherto assumed, (2) share typical molecular features with other BL, and (3) predominantly affect women in the fertile age.

Primary ovarian Burkitt's lymphoma presentation in a young woman: A case report.

Introduction and importanceBurkitt's lymphoma is one of the fastest growing human cancers and it needs a rapid diagnosis.Case presentationA young woman presented to our institution with acute abdominal pain, tenderness and constipation. Ultrasound reported a right ovarian mass; at laparoscopy, we discovered ascites, peritoneal carcinomatosis and a voluminous pelvic mass.Clinical discussionDiagnosis was confirmed as non-Hodgkin sporadic Burkitt's lymphoma: the careful workup was the key to initiate multiagent chemotherapy.ConclusionPrimary ovarian Burkitt's lymphoma, in a young woman in a non-endemic zone, is a rarity that represents a strong diagnostic challenge, but rapid identification can lead the patient to appropriate therapies and improvement of prognosis.

Étude rétrospective rapportant 20 cas de lymphome de Burkitt de localisation ovarienne pris en charge au CHU de Yopougon en Côte d’Ivoire

The maxillo-facial attack was the first described in the Burkitt lymphoma in 1958 by Denis Pearsons Burkitt. Abdominopelvic disorders, particularly ovarian localization are observed more and more by the developments of imagery technics. Our study aimed to describe the epidemiologic, clinical, therapeutic and evolutive aspects of ovarian localization in the endemic Burkitt lymphoma. Twenty files of ovarian Burkitt lymphoma diagnosed in the clinical service of hematology TH of Yopougon during the period August 1995-March 2015 (19 years) were retrospectively analyzed. The epidemiologic, clinical, therapeutic and evolutive parameters were studied. Ovarian Burkitt lymphoma accounted for 20.41% of the population with Burkitt lymphoma and 38.46% for patients with Burkitt lymphoma. The average age was 20.4 years with extremes of 6 and 38 years. The main reasons for consultation were general impairment (85%) and pelvic mass (80%). 75% were in group B clinical scalability. The ovarian mass was bilateral in 60% of cases, heterogeneous in 75% of cases. There was a clear predominance of stage III of Murphy (55%). On the evolutionary level all the patients treated by chemotherapy were in incomplete remission (100%). 10% were alive. 83.33% of the deceased patients had received less than 6 courses of chemotherapy. The diagnosis of ovarian endemic Burkitt lymphoma is most often delayed diagnosis and poor prognosis. Improving its management requires early diagnosis.

Ovarian Burkitt lymphoma: one case report

A 12-year-old female patient was admitted to this hospital on March 19, 2015, because of lower abdominal pain lasting longer than one month. She had an appendectomy in a local hospital two months before admission. Two weeks after this operation, she began experiencing intermittent idiopathic pain in the lower abdomen, which progressively worsened. After admission, the physical examination, B-ultrasound, and enhanced CT revealed several lumpy shadows of mixed density in the pelvic and celiac areas, with a maximum lesion of 14.7×10.5 cm and unclear borders. The concentration of carbohydrate antigen 125 (CA-125) was significantly elevated. Surgery and rapid pathology confirmed the diagnosis of a left ovarian malignant tumor, and routine pathology further indicated ovarian Burkitt lymphoma.

Appendiceal and ovarian Burkitt's lymphoma presenting as acute appendicitis

Abstract Burkitt's lymphoma is an extremely aggressive B-cell non-Hodgkin lymphoma. Patients with the sporadic form of Burkitt's lymphoma typically present with a rapidly growing abdominal mass, pain and distension. Involvement of either the appendix and/or ovaries in females is a rare manifestation of the disease. We present an unusual case of a 13 year old girl with appendiceal and ovarian Burkitt's lymphoma presenting with signs of acute appendicitis. This case demonstrates the potential for secondary involvement of the appendix and/or ovaries from Burkitt's lymphoma as well as the importance of the histopathology.

Primary ovarian Burkitt lymphoma: a case report and literature review

目的 探讨原发性伯基特淋巴瘤（BL）的临床病理和免疫表型特征。 方法 对1例散发性卵巢BL患者肿瘤组织进行病理形态学、免疫组织化学检测，并结合临床特征进行临床病理分析。 结果 患者，36岁。光学显微镜下BL瘤细胞呈弥漫一致的中等大细胞，伴有星空现象和多量的核碎片，易见核分裂象。免疫表型示瘤细胞CD20+和（或）CD79a+、Ki-67+++，bcl-2、TdT和MPO均阴性。 结论 BL属高度恶性淋巴瘤，主要应与淋巴母细胞性淋巴瘤、髓系白血病及非淋巴造血系统小细胞恶性肿瘤等相鉴别。

Intraoperative diagnosis by frozen section study would prevent unnecessary surgery in ovarian Burkitt′s lymphoma

Sir, Ovarian Burkitt's lymphoma is a rare form of malignant ovarian tumors accounting for 1% of all ovarian neoplasms.[1,2,3] It has been reported as a cause of ovarian torsion.[4] Herein, we briefly report a case of bilateral ovarian Burkitt's lymphoma in a 29-year-old woman presenting with vague suprapubic pain and abdominal distension. On physical examination, a rather large midline pelvic mass with abdominal extension was palpated. Serum beta hCG was negative and serum CA-125 level was within normal limits. Ultrasonography revealed homogenous and slightly echogenic large lobulated masses in both adnexae, each measuring approximately 10 cm in diameter. Pelvic and abdominal computed tomography confirmed the ultrasound findings and also detected enlarged paraaortic lymph nodes. The clinicoradiologic features of the tumor mimicked a primary malignant ovarian epithelial neoplasm despite the normal serum CA-125 level, and the patient became candidate for surgery. At surgery, peritoneal deposits and partial involvement of small intestine were also detected. The patient underwent surgical removal of the ovarian masses, paraaortic lymph node dissection, and peritoneal sampling. Permanent pathology revealed the ovarian masses to be Burkitt's lymphoma with the involvement of paraaortic lymph nodes and peritoneal seedings. The diagnosis was further confirmed by immunohistochemistry showing positive reactivity with leukocyte common antigen (LCA) and CD20 and CD10 markers. Following surgery, the patient underwent chemotherapy for Burkitt's lymphoma. However, an appropriate intraoperative management and diagnosis using tumor sampling and frozen section study would have avoided extensive and unnecessary surgery in this case. In fact, what made us consider extensive surgery was the presence of bilateral ovarian masses with diffuse peritoneal deposits and paraaortic lymphadenopathy, leading to an erroneous impression of primary malignant ovarian tumor originating from the surface epithelium. The main treatment of ovarian lymphoma is chemotherapy, and the overall prognosis of the tumor is good.[5,6] Spontaneous conception with live birth outcome has been reported following gonadotoxic chemotherapy for bilateral Burkitt's lymphoma.[7] The role of surgery is in question and debatable with the present available chemotherapeutic agents.[1] We do emphasize that, although rare, ovarian lymphoma should be considered in the differential diagnosis of advanced ovarian neoplasms, especially bilateral tumors in young women. Appropriate intraoperative management prevents unnecessary surgery in these cases.

EBV positive primary burkitt lymphoma involving bilateral ovaries: a case report

Introduction Burkitt lymphoma is a rare entity. This is a highly aggressive but potentially curable disease with extremely short doubling time and often presents in extranodal sites. Case report We report a case of primary ovarian Burkitt lymphoma involving bilateral ovaries in a 3-year-old female child who presented with abdominal distension and bilateral adnexal masses on ultrasonography. Materials and methods Both the adnexae were removed and routine histopathological examination was followed by immunohistochemical analysis and in situ hybridization using EBER probes for Epstein-Barr virus. Fluorescent in situ hybridization technique was performed for detection of cytogenetic abnormality. Results Morphology was suggestive of Burkitt lymphoma with CD20 positivity and high MIB-1 staining but negative for TdT. The tumor was reactive for CD10 and BCL6 and strongly positive for MUM1. The anti-BCL2 antibody showed moderate cytoplasmic immunoreactivity. Anti-immunoglobulin antibodies showed a monoclonal staining pattern, L positive, IgM+, IgD+. In situ hybridization for EBV showed nuclear staining of most of the tumor cells. MYC translocation was detected using FISH. Conclusion Burkitt lymphoma should be considered in the differential diagnosis of ovarian masses in children. Thorough work-up is mandatory for finalizing the diagnosis and staging of the disease.

Burkitt lymphoma of the ovary: A case report and literature review

We report an extremely rare case of primary ovarian Burkitt lymphoma. A 15-year-old girl was referred to our department because of persistent constipation and abdominal distension. Abdominal computed tomography and magnetic resonance imaging revealed a 10-cm-diameter solid tumor located on the right side of the uterus. Serum lactate dehydrogenase and carbohydrate antigen-125 levels were elevated at 3250 IU/L and 235.7 U/mL, respectively. Initially, ovarian dysgerminoma was suspected, but poor performance and progressive disease were suggestive of malignant lymphoma. However, bone marrow aspiration and ascitic fluid cytology findings were not indicative of lymphoma. Laparotomy was performed to confirm pathology. On laparotomy, the right ovary was firm and enlarged, but the uterus and left ovary were normal. Diffuse thickness of retroperitoneal space was observed. Right salpingo-oophorectomy was performed, and the tumor was diagnosed as Burkitt lymphoma. Although intensive chemotherapy was administered, the patient died 171 days after the initial operation.

Primary Burkitt's Lymphoma of the Ovary in Early Weeks of Pregnancy - A Case Report.

Primary ovarian Burkitt's lymphoma is a rare tumour predominantly affecting children and young adults. We report here on a 17-year-old pregnant woman with a Burkitt's lymphoma of the left ovary. After tumour removal and induced abortion, the patient underwent polychemotherapy. Full remission was achieved 7 months after the initial diagnosis.

Primary ovarian Burkitt lymphoma

Primary ovarian Burkitt lymphoma (BL) is a rare neoplasm in adults. We report a 30-year-old woman diagnosed with primary bilateral ovarian BL. She presented features of a twisted ovarian cyst and underwent bilateral salpingo-oophorectomy. The histopathologic evaluation yielded the diagnosis of BL and subsequently she received chemoimmunotherapy with CODOX-M-IVAC plus rituximab (anti-CD20 monoclonal antibody).

Ovarian Burkitt's lymphoma diagnosed by a combination of clinical features, morphology, immunophenotype, and molecular findings and successfully managed with surgery and chemotherapy

Ovarian involvement as an initial manifestation of lymphoma, without detectable extraovarian disease, is a rare occurrence. The diagnosis of ovarian lymphoma is almost invariably unsuspected until the tumor has been examined histologically. A 25-year-old null gravid woman presented with abdominal distension. Presence of abnormal lymphoid cells in pleural effusion led to presurgical assumption that the pelvic mass noted on computerized tomography examination might be an ovarian lymphoma. We performed left salpingo-oophorectomy. Clinical, histologic, and molecular examination revealed Burkitt's lymphoma of the ovary with c-myc gene rearrangement and mRNA expression of multiple cytokines. She received dose-intensified combination chemotherapy. She is alive and free of disease 30 months after the diagnosis. Immunophenotype and molecular findings allowed reliable discrimination of Burkitt's lymphoma from diffuse large B-cell lymphoma and other lymphomas. If an ovarian tumor is solid and suspected to be of lymphoid origin, we suggest that it is necessary to obtain samples for genetic examination at surgery. This strategy often provides important information to establish therapeutic regimen and predict patient prognosis.

Ovarian Burkitt's lymphoma diagnosed by a combination of clinical features, morphology, immunophenotype, and molecular findings and successfully managed with surgery and chemotherapy

Ovarian involvement as an initial manifestation of lymphoma, without detectable extraovarian disease, is a rare occurrence. The diagnosis of ovarian lymphoma is almost invariably unsuspected until the tumor has been examined histologically. A 25-year-old null gravid woman presented with abdominal distension. Presence of abnormal lymphoid cells in pleural effusion led to presurgical assumption that the pelvic mass noted on computerized tomography examination might be an ovarian lymphoma. We performed left salpingo-oophorectomy. Clinical, histologic, and molecular examination revealed Burkitt's lymphoma of the ovary with c-myc gene rearrangement and mRNA expression of multiple cytokines. She received dose-intensified combination chemotherapy. She is alive and free of disease 30 months after the diagnosis. Immunophenotype and molecular findings allowed reliable discrimination of Burkitt's lymphoma from diffuse large B-cell lymphoma and other lymphomas. If an ovarian tumor is solid and suspected to be of lymphoid origin, we suggest that it is necessary to obtain samples for genetic examination at surgery. This strategy often provides important information to establish therapeutic regimen and predict patient prognosis.

24-year-old female with amenorhea: bilateral primary ovarian Burkitt lymphoma

Background Burkitt's lymphoma (BL) occurs mostly in children. Isolated bilateral ovarian involvement presenting with amenorrhea is extremely rare in young adults. Case A 24-year-old female presented with secondary amenorrhea. Bilateral adnexal masses were identified on physical examination and abdominal computed tomography (CT). She underwent total abdominal histerectomy and bilateral salpingoophorectomy. Histopathologic evaluation yielded a diagnosis of BL of ovaries. Combined chemotherapy was administered. After complete remission an autologous bone marrow transplantation (ABMT) was performed. She died 35 days after ABMT. Conclusion Although rare, BL should be kept in mind when isolated ovarian tumors are detected in young patients.

Ovarian Burkitt lymphoma: Pelvic pain in a woman with AIDS

Non-Hodgkin lymphomas, a common AIDS-defining manifestation of human immunodeficiency virus (HIV), are aggressive, advanced at diagnosis, and tend to involve extranodal sites. Burkitt lymphoma comprises approximately 20% of AIDS-related non-Hodgkin lymphomas. Sites frequently affected by the disease include the central nervous system, bone marrow, gastrointestinal tract, and mucocutaneous tissue. Gonadal involvement is less common; reports of testicular lymphomas in adult males with AIDS have been sporadic. Ovarian involvement in AIDS-related lymphoma is exceedingly rare and usually involves pediatric patients. We report an unusual case in which disseminated Burkitt lymphoma presented as pelvic pain in a 32-year-old woman with AIDS. At laparoscopy, the ovaries were unremarkable in appearance but at the upper limits of normal size. However, extreme friability of the left ovary led to hemorrhage and oophorectomy. Pathologic evaluation of the ovary resulted in the diagnosis of Burkitt lymphoma. With improved survival because of antiretroviral therapy, the incidence of AIDS-related lymphomas is expected to rise. Lymphoma should be considered in the differential diagnosis of women with AIDS with perplexing abdominal or pelvic symptoms.

A Case of Ovarian Burkitt's Lymphoma with Hyperuricemic Renal Failure

A Case of Ovarian Burkitt's Lymphoma with Hyperuricemic Renal Failure