EBV positive primary burkitt lymphoma involving bilateral ovaries: a case report

Abstract

Introduction Burkitt lymphoma is a rare entity. This is a highly aggressive but potentially curable disease with extremely short doubling time and often presents in extranodal sites. Case report We report a case of primary ovarian Burkitt lymphoma involving bilateral ovaries in a 3-year-old female child who presented with abdominal distension and bilateral adnexal masses on ultrasonography. Materials and methods Both the adnexae were removed and routine histopathological examination was followed by immunohistochemical analysis and in situ hybridization using EBER probes for Epstein-Barr virus. Fluorescent in situ hybridization technique was performed for detection of cytogenetic abnormality. Results Morphology was suggestive of Burkitt lymphoma with CD20 positivity and high MIB-1 staining but negative for TdT. The tumor was reactive for CD10 and BCL6 and strongly positive for MUM1. The anti-BCL2 antibody showed moderate cytoplasmic immunoreactivity. Anti-immunoglobulin antibodies showed a monoclonal staining pattern, L positive, IgM+, IgD+. In situ hybridization for EBV showed nuclear staining of most of the tumor cells. MYC translocation was detected using FISH. Conclusion Burkitt lymphoma should be considered in the differential diagnosis of ovarian masses in children. Thorough work-up is mandatory for finalizing the diagnosis and staging of the disease.